Chloroquine –Induced Hair Depigmentation

Giacomo, Thais Bello Di; Valente, Neusa Yuriko Sakai; Nico, Marcello Menta Simonsen

doi:10.1177/0961203308097473

Cited by 14 publications

(5 citation statements)

References 14 publications

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“…This hypothesis is consistent with the fact that the main known risk factor for these hyperpigmented macules is the taking of antiaggregant or anticoagulant treatment [115,116]. Concerning the depigmentation of integuments, mechanisms of 4-AQ-induced poliosis and vitiligo remain unclear; the main hypothesis is that 4-AQ bind to eumelanin and pheomelanin and so disturb melanogenesis [122].…”

Section: Mechanismssupporting

confidence: 68%

Systemic toxicity of chloroquine and hydroxychloroquine: prevalence, mechanisms, risk factors, prognostic and screening possibilities

Müller

2021

Rheumatol Int

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Section: Mechanismssupporting

confidence: 68%

Systemic toxicity of chloroquine and hydroxychloroquine: prevalence, mechanisms, risk factors, prognostic and screening possibilities

Müller

2021

Rheumatol Int

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“…Chloroquine (CHL) is an antimalarial drug approved by both the Food and Drug Administration (FDA) and European Medicines Agency (EMA) for the treatment of lupus erythematosus and rheumatoid arthritis. Lightening on the hair scalp, and less frequently on the eyelashes, eyebrows, moustache and body hair, has been shown to be induced by CHL administered at a dosage starting from 250 mg daily [11][12][13][14][15][16][17][18][19][20][21][22][23]. Hair hypopigmentation (a brightening of any hair colour leading to whitening) occurred from four weeks up to 12 months after treatment initiation, and was reversible after discontinuation or dosage reduction.…”

Section: Drugs That Induce Hair Colour Changes Chloroquinementioning

confidence: 99%

“…The pathophysiological mechanism of hair and skin hypopigmentation during CHL treatment is not fully understood, but previous studies showed remarkable affinity of CHL for those tissues which have abundant melanin content, such as the skin and eyes [26]. Hypopigmentation was indeed more common in patients with blond, light brown, or red hair, suggesting a greater interaction between CHL and pheomelanin rather than eumelanin [21]. However, even subjects with darker hair may experience hair lightening [13,14,17].…”

Section: Drugs That Induce Hair Colour Changes Chloroquinementioning

confidence: 99%

Drug-induced hair colour changes

Ricci¹,

Simone²,

Regno³

et al. 2016

European Journal of Dermatology

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Drug-induced hair colour changesHair colour modifications comprise lightening/greying, darkening, or even a complete hair colour change, which may involve the scalp and/or all body hair. Systemic medications may cause hair loss or hypertrichosis, while hair colour change is an uncommon adverse effect. The rapidly increasing use of new target therapies will make the observation of these side effects more frequent. A clear relationship between drug intake and hair colour modification may be difficult to demonstrate and the underlying mechanisms of hair changes are often unknown. To assess whether a side effect is determined by a specific drug, different algorithms or scores (e.g. Naranjo, Karch, Kramer, and Begaud) have been developed. The knowledge of previous similar reports on drug reactions is a key point of most algorithms, therefore all adverse events should be recognised and reported to the scientific community. Furthermore, even if hair colour change is not a life-threatening side effect, it is of deep concern for patient's quality of life and adherence to treatment. We performed a review of the literature on systemic drugs which may induce changes in hair colour.

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“…Hair graying is associated with various autoimmune disorders including vitiligo and several rare premature aging syndromes including the Hutchinson Gilford and Werner'syndrome 7 . Hair graying may also reflect nutritional deficiencies (especially of vitamins) and the use of drugs such as chloroquine 8 9 10 . We do not know exactly the cause of hair graying in humans.…”

Section: Introductionmentioning

confidence: 99%

Three Streams for the Mechanism of Hair Graying

Lee

et al. 2018

Ann Dermatol

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Hair graying is an obvious sign of human aging. Although graying has been investigated extensively, the mechanism remains unclear. Here, we reviewed previous studies on the mechanism of graying and seek to offer some new insights. The traditional view is that hair graying is caused by exhaustion of the pigmentary potential of the melanocytes of hair bulbs. Melanocyte dysfunction may be attributable to the effects of toxic reactive oxygen species on melanocyte nuclei and mitochondria. A recent study suggests that bulge melanocyte stem cells (MSCs) are the key cells in play. Graying may be caused by defective MSC self-maintenance, not by any deficiency in bulbar melanocytes. Our previous study suggested that graying may be principally attributable to active hair growth. Active hair growth may produce oxidative or genotoxic stress in hair bulge. These internal stress may cause eventually depletion of MSC in the hair follicles. Taken together, hair graying may be caused by MSC depletion by genotoxic stress in the hair bulge. Hair graying may also be sometimes caused by dysfunction of the melanocytes by oxidative stress in the hair bulb. In addition, hair graying may be attributable to MSC depletion by active hair growth.

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Chloroquine –Induced Hair Depigmentation

Cited by 14 publications

References 14 publications

Systemic toxicity of chloroquine and hydroxychloroquine: prevalence, mechanisms, risk factors, prognostic and screening possibilities

Systemic toxicity of chloroquine and hydroxychloroquine: prevalence, mechanisms, risk factors, prognostic and screening possibilities

Drug-induced hair colour changes

Three Streams for the Mechanism of Hair Graying

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