2020
DOI: 10.1136/vetreccr-2020-001205
|View full text |Cite
|
Sign up to set email alerts
|

Chlorphenamine for prolonged drug‐induced extrapyramidal side effects in a dog

Abstract: An eight-year-old male entire crossbreed dog, evaluated for resection of a mass at the base of the tail, underwent general anaesthesia for CT. Following preanaesthetic medication of 0.2 mg/kg butorphanol and 0.015 mg/kg acepromazine intravenously, anaesthesia was induced with 2 mg/kg alfaxalone and 0.3 mg/kg midazolam intravenously. Anaesthesia was uneventful, although during recovery the dog showed prolonged excitatory signs consisting of intermittent opisthotonic posture, limb dystonia, myoclonic jerks, padd… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
7
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
3

Relationship

1
2

Authors

Journals

citations
Cited by 3 publications
(7 citation statements)
references
References 36 publications
(78 reference statements)
0
7
0
Order By: Relevance
“…1 Differential diagnoses for PxDs (often characterized by dystonia) and their differentiating characteristics are largely based on phenomenology and have been discussed in other reviews and include syncope, PxD and other movement disorders, narcolepsy, cataplexy, neuromuscular weakness, paroxysmal behavioral disorders (compulsive disorders), vestibular dysfunction and epileptic seizures. 1,8,35 The clinical sign of dystonia itself should be differentiated from similar clinical signs that can have similar phenomenology consisting of sustained or intermittent involuntary muscle contractions causing abnormal (often repetitive) movements, postures, or both. For instance, a dog with severe lameness may hold a limb in a flexed position off the ground, but does so voluntarily and the dystonia may be countered intermittently by the dog or by manipulation of the limb by the owner or clinician.…”
Section: Diagnostic and Treatment Considerationsmentioning
confidence: 99%
See 4 more Smart Citations
“…1 Differential diagnoses for PxDs (often characterized by dystonia) and their differentiating characteristics are largely based on phenomenology and have been discussed in other reviews and include syncope, PxD and other movement disorders, narcolepsy, cataplexy, neuromuscular weakness, paroxysmal behavioral disorders (compulsive disorders), vestibular dysfunction and epileptic seizures. 1,8,35 The clinical sign of dystonia itself should be differentiated from similar clinical signs that can have similar phenomenology consisting of sustained or intermittent involuntary muscle contractions causing abnormal (often repetitive) movements, postures, or both. For instance, a dog with severe lameness may hold a limb in a flexed position off the ground, but does so voluntarily and the dystonia may be countered intermittently by the dog or by manipulation of the limb by the owner or clinician.…”
Section: Diagnostic and Treatment Considerationsmentioning
confidence: 99%
“…Of note, drug-induced extrapyramidal signs in humans, dogs and horses have been treated successfully using anticholinergic or antihistamine drugs such as chlorphenamine, diphenhydramine and benztropine. 35,36,46 Inciting drugs and drugs used for treatment are postulated to exert their effects by influencing monoamine (e.g., dopamine) neurotransmitter receptors. These observations may be considered for treatment of nondrug-induced dystonia cases, but no large studies on dogs with PxD characterized by dystonia and treated with such medications are available.…”
Section: Various Medical Treatments Have Been Reported For Dogs Withmentioning
confidence: 99%
See 3 more Smart Citations