Chlorpheniramine maleate containing chitosan-based nanoparticle-loaded thermosensitive in situ gel for management in allergic rhinitis

Kumar, Manish; Upadhayay, Pooja; Shankar, Ravi; Joshi, Monika; Bhatt, Shailendra; Malik, Anuj

doi:10.1007/s13346-019-00639-w

Cited by 14 publications

(11 citation statements)

References 24 publications

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“…Then, a 35 g weight was placed on the gel solution and allowed to penetrate 5 cm in the gel. Time taken by weight to sink 5 cm was measured [ 29 ].…”

Section: Methodsmentioning

confidence: 99%

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Chitosan Hydrogel Doped with PEG-PLA Nanoparticles for the Local Delivery of miRNA-146a to Treat Allergic Rhinitis

Sun

Gao

et al. 2020

Pharmaceutics

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To prepare a binary formulation delivering miRNA-146 and evaluate a nucleic acid nasal delivery system by investigating its pharmacodynamic effects in allergic rhinitis. The gel/NPs/miR-146a thermosensitive in situ chitosan hydrogel carrying a nucleic acid was prepared and evaluated for its characteristics, including temperature sensitivity, gel strength, mucosal adhesion and drug release profile. After nasal administration of the formulation to ovalbumin-sensitized rats, the treatment of allergic rhinitis was verified by assessing nasal symptoms, hematology, hematoxylin-eosin (HE) staining and immunohistochemistry. Western Blot(WB) was used to analyze nasal inflammatory factors as well as miRNA-146-related factors, and the miR146 expression level was measured by PCR. Subsequently, the effects of the gel/NPs/miR-146a binary formulation were evaluated for the nasal delivery of nucleic acids in rhinitis therapy. The prepared binary formulation quickly formed a gel in the nasal cavity at a temperature of 34 °C with good mucosal adhesion, which delivered nucleic acids into the nasal mucosa stably and continuously. Gel/NPs/miR-146a was able to sustain the delivery of miRNA into the mucosa after nasal administration. When compared with the monolithic formulations, the gel/NPs/miR-146a binary formulation performed better regarding its nucleic acid delivery ability and pharmacodynamic effects. The gel/NPs/miR-146a binary preparation has a suitable nasal mucosal drug delivery ability and has a positive pharmacodynamic effect for the treatment of ovalbumin-induced rhinitis in rats. It can serve as a potential nucleic acid delivery platform for the treatment of allergic rhinitis.

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“…Then, a 35 g weight was placed on the gel solution and allowed to penetrate 5 cm in the gel. Time taken by weight to sink 5 cm was measured [ 29 ].…”

Section: Methodsmentioning

confidence: 99%

“…Each sample (50 g) was transferred to a 100 mL graduated cylinder and gelled in a constant temperature water bath at 34 • C. Then, a 35 g weight was placed on the gel solution and allowed to penetrate 5 cm in the gel. Time taken by weight to sink 5 cm was measured [29].…”

Section: Determination Of Gelation Time Gel Strength and Mucosal Adhesionmentioning

confidence: 99%

Chitosan Hydrogel Doped with PEG-PLA Nanoparticles for the Local Delivery of miRNA-146a to Treat Allergic Rhinitis

Sun

Gao

et al. 2020

Pharmaceutics

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“…These symptoms typically result in poor retention and limited uptake of free therapeutics . Accordingly, mucoadhesive nanoparticles have improved treatment outcomes by enhancing retention in the nasal mucosa. , For example, chitosan-based mucoadhesive nanoparticles facilitated antiallergy effectiveness (near control levels of histamine, TNF-α, IL-4 and 5) at reduced treatment frequency (every 4 d) compared to free drug by combining antihistamine drug release with histamine receptor agonist-functionalized chitosan (Figure d) . An important insight from the treatment of localized nasal conditions is the change in local environment and its impact on drug delivery.…”

Section: Mucosae and Nanoparticle Designmentioning

confidence: 99%

Untangling Mucosal Drug Delivery: Engineering, Designing, and Testing Nanoparticles to Overcome the Mucus Barrier

Watchorn

Clasky

Prakash

et al. 2022

ACS Biomater. Sci. Eng.

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Mucus is a complex viscoelastic gel and acts as a barrier covering much of the soft tissue in the human body. High vascularization and accessibility have motivated drug delivery to various mucosal surfaces; however, these benefits are hindered by the mucus layer. To overcome the mucus barrier, many nanomedicines have been developed, with the goal of improving the efficacy and bioavailability of drug payloads. Two major nanoparticle-based strategies have emerged to facilitate mucosal drug delivery, namely, mucoadhesion and mucopenetration. Generally, mucoadhesive nanoparticles promote interactions with mucus for immobilization and sustained drug release, whereas mucopenetrating nanoparticles diffuse through the mucus and enhance drug uptake. The choice of strategy depends on many factors pertaining to the structural and compositional characteristics of the target mucus and mucosa. While there have been promising results in preclinical studies, mucus−nanoparticle interactions remain poorly understood, thus limiting effective clinical translation. This article reviews nanomedicines designed with mucoadhesive or mucopenetrating properties for mucosal delivery, explores the influence of site-dependent physiological variation among mucosal surfaces on efficacy, transport, and bioavailability, and discusses the techniques and models used to investigate mucus−nanoparticle interactions. The effects of non-homeostatic perturbations on protein corona formation, mucus composition, and nanoparticle performance are discussed in the context of mucosal delivery. The complexity of the mucosal barrier necessitates consideration of the interplay between nanoparticle design, tissue-specific differences in mucus structure and composition, and homeostatic or disease-related changes to the mucus barrier to develop effective nanomedicines for mucosal delivery.

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“…The preparation of thermosensitive gel is based on the solubilization of water at the starting point and is dissolved in deionized water at 4 °C until it forms a clarified solution [ 13 , 35 , 36 ]. In this process, continuous slow stirring is needed to avoid foam formation [ 24 ].…”

Section: Subjectsmentioning

confidence: 99%

“…As an ideal drug delivery carrier, thermosensitive gels are widely used in the biomedical field. For example, it has shown great potential in the study of prolonged drug release for ocular administration and the treatment of allergic rhinitis [ 13 , 14 ]. Another formulation which incorporates glass containing Ho 2 O 3 exhibits suitable properties as theragenerative material for bone cancer treatment [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

An Overview on Thermosensitive Oral Gel Based on Poloxamer 407

et al. 2021

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In this review, we describe the application of thermosensitive hydrogels composed of poloxamer in medicine, especially for oral cavities. Thermosensitive hydrogels remain fluid at room temperature; at body temperature, they become more viscous gels. In this manner, the gelling system can remain localized for considerable durations and control and prolong drug release. The chemical structure of the poloxamer triblock copolymer leads to an amphiphilic aqueous solution and an active surface. Moreover, the poloxamer can gel by forming micelles in an aqueous solution, depending on its critical micelle concentration and critical micelle temperature. Owing to its controlled-release effect, a thermosensitive gel based on poloxamer 407 (P407) is used to deliver drugs with different characteristics. As demonstrated in studies on poloxamer formulations, an increase in gelling viscosity decreases the drug release rate and gel dissolution time to the extent that it prolongs the drug’s duration of action in disease treatment. This property is used for drug delivery and different therapeutic applications. Its unique route of administration, for many oral diseases, is advantageous over traditional routes of administration, such as direct application and systemic treatment. In conclusion, thermosensitive gels based on poloxamers are suitable and have great potential for oral disease treatment.

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Chlorpheniramine maleate containing chitosan-based nanoparticle-loaded thermosensitive in situ gel for management in allergic rhinitis

Cited by 14 publications

References 24 publications

Chitosan Hydrogel Doped with PEG-PLA Nanoparticles for the Local Delivery of miRNA-146a to Treat Allergic Rhinitis

Chitosan Hydrogel Doped with PEG-PLA Nanoparticles for the Local Delivery of miRNA-146a to Treat Allergic Rhinitis

Untangling Mucosal Drug Delivery: Engineering, Designing, and Testing Nanoparticles to Overcome the Mucus Barrier

An Overview on Thermosensitive Oral Gel Based on Poloxamer 407

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