Chlorpromazine

Maxwell, Robert A.; Eckhardt, Shohreh B.

doi:10.1007/978-1-4612-0469-5_8

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…Schizophrenia is a severe, chronic psychological disorder characterized by the presence of positive, negative, and cognitive symptoms. − Until the mid-20th century a diagnosis of schizophrenia historically meant a lifetime of confinement to an asylum. − Standard treatments of the time were electroconvulsive therapy (ECT) and prolonged sleep therapy, which were employed with agitated patients. ,− The introduction of chlorpromazine (CPZ) in the early 1950s catalyzed the development of psychopharmacology and expanded our understanding of chemical signaling in neurotransmission . Additionally, CPZ helped to reduce the public stigma surrounding mental illness, leading to the deinstitutionalization of those with schizophrenia. ,,, In this review, we attempt to synthesize a portion of the literature on CPZ to describe the synthesis and basic properties of this first-generation antipsychotic that has persisted for almost 70 years as the “gold standard” to which all other antipsychotics are compared.…”

Section: Introductionmentioning

confidence: 99%

Classics in Chemical Neuroscience: Chlorpromazine

Boyd‐Kimball

Gonczy

Lewis

et al. 2018

ACS Chem. Neurosci.

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The discovery of chlorpromazine in the early 1950s revolutionized the clinical treatment of schizophrenia, galvanized the development of psychopharmacology, and standardized protocols used for testing the clinical efficacy of antipsychotics. Furthermore, chlorpromazine expanded our understanding of the role of chemical messaging in neurotransmission and reduced the stigma associated with mental illness, facilitating deinstitutionalization in the 1960s and 1970s. In this review, we will discuss the synthesis, manufacturing, metabolism and pharmacokinetics, pharmacology, structure-activity relationship, and adverse effects of chlorpromazine. In conclusion, we summarize the history and significant contributions of chlorpromazine that have resulted in this potent first-generation antipsychotic maintaining its clinical relevance for nearly 70 years.

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