Chlorpropamide: Dangerous Hypoglycæmia in Old Age ?

Schen, R. J.

doi:10.1016/s0140-6736(73)90430-3

Cited by 4 publications

(1 citation statement)

References 4 publications

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“…Therapeutic effects are reached with half of the maximal recommended dose for these drugs, and sulfonylureas do not affect lipid levels or blood pressure. The long half life of chlorpropamide may result in accumulation leading to precipitous hypoglycemia, especially in elders [67]. However, sulfonylurea is ineffective in 10-20% of the NIDDM patients [59].…”

Section: Oral Hypoglycemic Agentsmentioning

confidence: 99%

Type 2 Diabetes and Oral Antihyperglycemic Drugs

Mizuno

Chittiboyina²,

Kurtz³

et al. 2008

CMC

112

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Type II diabetes is a heterogeneous disease where environment and genetics are important factors for the expression of the disease. The high cost for treating complications of diabetes is a burden for public health systems and governments worldwide. Type II diabetes has been causing debilitation worldwide for many decades, and a single drug that safely treats the disease has yet to be discovered. Sulfonylureas, biguanides, alpha-glucosidase, meglitinides, DPP-4 inhibitors and thiazolidinediones are among the classes of oral hypoglycemic drugs available to treat Type II diabetes, but concerns exist regarding safety and efficacy of these drugs. In this article we present the pros and cons of the six classes and discuss some of the latest advances towards the development of new drugs for the treatment of Type II diabetes.

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Section: Oral Hypoglycemic Agentsmentioning

confidence: 99%