Chlorpyrifos and Δ9 Tetrahydrocannabinol exposure and effects on parameters associated with the endocannabinoid system and risk factors for obesity

Silva, Marilyn H.

doi:10.1016/j.crtox.2021.08.002

Cited by 7 publications

(5 citation statements)

References 153 publications

(167 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, Akhtar et al, 2009 revealed a significant body weight decrease at a high dose (9 mg kg −1 d −1 ) of chlorpyrifos [ 12 ]. Conversely, Silva in 2021 reported that males exposed to CPF showed increased body weights [ 51 ]. Perinatal exposure to CPF causes indirect toxicity for rat offspring by leading to a hormonal disorder through the endocrine-disrupting property [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Impact of Perinatal Coexposure to Chlorpyrifos and a High-Fat Diet on Kisspeptin and GnRHR Presence and Reproductive Organs

Lahimer,

Djekkoun,

Tricotteaux-Zarqaoui

et al. 2023

Toxics

View full text Add to dashboard Cite

Emerging evidence has indicated the involvement of extrahypothalamic Kisspeptin and GnRHR in reproductive function. In this study, we evaluate if maternal exposure to the pesticide chlorpyrifos (CPF) and/or a high-fat diet (HFD) has an impact on the expression of Kisspeptin and GnRHR in the reproductive organs of rats’ offspring. A total of 16 pregnant rats are divided into four groups: a control group (n = 4), CPF group (4 rats exposed daily to 1/mg/kg/day), HFD group (4 rats randomly fed a 5.25 kcal/g HFD), and coexposed group (4 rats exposed to CPF and HDF). At postnatal development postnatal day (PND) 60, male and female offspring were sacrificed. The reproductive organs (ovary and testis) were removed, and histological and immunohistological analysis and in silico quantification (TissueGnostics software 6.0.1.102, TissueFAXS, HistoQuest) were applied to investigate the impact of different treatments on Kisspeptin and GnRHR expression in reproductive organs. The main outcomes of the study showed a significant decrease in rat offspring’s body weight in the CPF group from PND30 and PND60 (p < 0.05 and p < 0.01, respectively). Histological analysis showed a significant increase in the atretic follicle and abnormal testis structure with germ cell desquamation in the CPF-exposed group. The immunodetection quantification of protein shows a significant decrease in GnRHR and Kisspeptin in the HFD and CPF exposed groups, respectively, in testis rat offspring. Perinatal exposure to CPF and HFD exposure affect the reproduction function of rat offspring.

show abstract

Section: Discussionmentioning

confidence: 99%

Impact of Perinatal Coexposure to Chlorpyrifos and a High-Fat Diet on Kisspeptin and GnRHR Presence and Reproductive Organs

Lahimer,

Djekkoun,

Tricotteaux-Zarqaoui

et al. 2023

Toxics

View full text Add to dashboard Cite

show abstract

“…Today, studies on mice 3T3-L1 models are being carried out and a study by Blanco et al suggests that CPF and its metabolite 3,5,6-trichlorpyridinol (TCP) affect metabolism during adipogenesis, by increasing the number of differentiated 3T3-L1 adipocytes and the capacity for storage of lipid droplets. This process is linked to an up-regulation of the transcription factors CCAAT/enhancer binding protein α (C/EBP α) and PPARγ, which is accompanied by a significantly higher expression of fatty acid-binding protein 4 (FABP4) adipokine [86,87]. Diazinon This pesticide and nematocide was widely used in agriculture and commonly detected in the human population.…”

Section: Organophosphate Pesticides (Opps)mentioning

confidence: 99%

Obesogens in Foods

et al. 2022

View full text Add to dashboard Cite

Obesogens, as environmental endocrine-disrupting chemicals, are supposed to have had an impact on the prevalence of rising obesity around the world over the last forty years. These chemicals are probably able to contribute not only to the development of obesity and metabolic disturbances in individuals, but also in their progeny, having the capability to epigenetically reprogram genetically inherited set-up points for body weight and body composition control during critical periods of development, such as fetal, early life, and puberty. In individuals, they may act on myriads of neuro-endocrine–immune metabolic regulatory pathways, leading to pathophysiological consequences in adipogenesis, lipogenesis, lipolysis, immunity, the influencing of central appetite and energy expenditure regulations, changes in gut microbiota–intestine functioning, and many other processes. Evidence-based medical data have recently brought much more convincing data about associations of particular chemicals and the probability of the raised risk of developing obesity. Foods are the main source of obesogens. Some obesogens occur naturally in food, but most are environmental chemicals, entering food as a foreign substance, whether in the form of contaminants or additives, and they are used in a large amount in highly processed food. This review article contributes to a better overview of obesogens, their occurrence in foods, and their impact on the human organism.

show abstract

“…A similar result was reported after challenging the common carp ( C. carpio L.) with trichlorfon, 234 an organophosphate pesticide frequently used in agriculture and aquaculture to control parasitic infections. The application of this pesticide damaged the intestinal barrier and induced dysbiosis 235 …”

Section: Factors Leading To Diseasementioning

confidence: 99%

Fish disease and intestinal microbiota: A close and indivisible relationship

Félix

Garibay-Valdez

Vargas‐Albores

et al. 2022

Reviews in Aquaculture

View full text Add to dashboard Cite

The gut microbiota is currently one of the most studied 'organs' in animals, and fish are no exception. A complex diversity of microbes, including bacteria, archaea, yeast and fungus, constitute the gut microbiota, creating a complex interaction with their host and accomplishing multiple beneficial functions, such as food digestion, nutrient absorption, immune system, endocrine and stress response. The microbiotapathogen interaction protects the host by mounting colonization resistance, competing for nutrients and space. Changes in the balance of the microbiota community could affect their structure and homeostasis, inducing dysbiosis. In addition, invading pathogens can induce dysbiosis by evading the host's defence barriers, acquiring nutrients from the fish host, using metabolites produced by the microbiota and producing toxins. In this regard, understanding the interactions within the fish gut microbiota is essential to prevent pathogen establishment in the host. Hence, this review describes the close and indivisible relationships and interactions between gut microbiota and pathogens that could lead to dysbiosis and disease.

show abstract

Chlorpyrifos and Δ9 Tetrahydrocannabinol exposure and effects on parameters associated with the endocannabinoid system and risk factors for obesity

Abstract: Graphical abstract

Cited by 7 publications

References 153 publications

Impact of Perinatal Coexposure to Chlorpyrifos and a High-Fat Diet on Kisspeptin and GnRHR Presence and Reproductive Organs

Impact of Perinatal Coexposure to Chlorpyrifos and a High-Fat Diet on Kisspeptin and GnRHR Presence and Reproductive Organs

Obesogens in Foods

Fish disease and intestinal microbiota: A close and indivisible relationship

Contact Info

Product

Resources

About