“…This question is based on prior work by Hikosaka (2009, 2011) and Charpentier and colleagues (2018), who demonstrated that the desire for knowledge in non-instrumental settings implicates the mesolimbic reward circuitry. We investigated to what extent curiosity and the motives underlying human curiosity, such as outcome uncertainty (Kobayashi et al, 2019;Romero Verdugo, van Lieshout, de Lange, & Cools, 2020;van Lieshout, de Lange, & Cools, 2020a;van Lieshout et al, 2018;van Lieshout, Traast, et al, 2019), outcome valence (Charpentier et al, 2018;Marvin & Shohamy, 2016;van Lieshout et al, 2020a, van Lieshout, Traast, et al, 2019 and expected value (Charpentier et al, 2018;Kobayashi et al, 2019;Romero Verdugo et al, 2020;van Lieshout, Traast, et al, 2019), correlate with an individual's dopamine synthesis capacity, measured with [ 18 F]DOPA positron emission tomography (PET).…”