The purpose of this research is to describe the empowerment of poor families in Jayapura city through conditional cash transfer program. This study used qualitative descriptive analysis method focusing on PKH or Family Hope Program beneficiary's family. The results show that indicators of empowerment of poor families have turned into better welfare conditions, such as active family participation in groups, changing perspectives on poverty, broad social network connections, and behavioral changes to the utilization of education, health services and decision-making processes in family. There are factors affecting conditions above, such as human resources involved in the program, cultural systems, social and economic system, and politics in the community which largely contribute to the powerlessness of poor families. This research concludes that empowering poor families requires commitment of stakeholders towards sustainable, integrated, and culturally sensitive conditional cash transfer program.