Choice of Aspiration Prevention Surgery for Patients With Neuromuscular Disorders: Report of Three Cases

Abstract

Dysphagia, one of the major complications of neuromuscular diseases such as Parkinson's disease and amyotrophic lateral sclerosis (ALS), decreases quality of life and may lead to malnutrition or aspiration pneumonia. Although recent reports have suggested that surgical aspiration prevention improves quality of life and enables oral intake, the selection of appropriate aspiration prevention techniques has rarely been discussed. In this report, we present the cases of three patients with neuromuscular diseases who underwent surgical aspiration prevention; we selected the surgical techniques based on analysis of the dysphagia mechanisms, disease progression, and general condition in each case. Case 1 was a 55-year-old man with multiple system atrophy (MSA) and presented with dysphagia associated with insufficient upper esophageal sphincter (UES) relaxation. We performed central-part laryngectomy, which was able to improve UES relaxation. Case 2 was a 79-year-old man with progressive supranuclear palsy who presented with respiratory disorder and dysphagia. Glottic closure under local anesthesia was selected because he also had acute hepatobiliary dysfunction and methicillin-resistant Staphylococcus aureus pneumonia with pleural effusion. Case 3 was a 75-year-old man with ALS and presented with respiratory disorder and mild dysphagia. Subglottic closure with total cricoidectomy was selected because his dysphagia was expected to worsen due to tracheostomy and disease progression. We also summarize the characteristics of the aspiration prevention surgical techniques based on our cases and on literature review. The causes of dysphagia, including insufficient UES opening during swallowing, weak pharyngeal constriction, velopharyngeal insufficiency, and inadequate laryngeal elevation, should be assessed by detailed examination before surgery, and the type of aspiration prevention surgery should be selected based on patient swallowing function and general condition.

Aspiration prevention surgeries: a review

“…A permanent tracheostomy was created afterward. Later on, Miyake et al [ 59 ] and Ueha et al [ 21 ] modified the original method by leaving the posterior cricoid cartilage and adding cricopharyngeal myotomy. Subglottic laryngeal closure is possible under general or local anesthesia.…”

Long-term outcomes after surgery to prevent aspiration for patients with amyotrophic lateral sclerosis

“…To the best of our knowledge, few studies have examined the long-term effects of surgery to prevent aspiration on the feeding status of patients with ALS [ 10 ]. In this study, we investigated the long-term course of patients with ALS after surgery to prevent aspiration.…”

Esophageal Speech for a Patient with Amyotrophic Lateral Sclerosis Who Underwent a Central-part Laryngectomy to Prevent Aspiration: A Case Report

“…Less invasive methods, such as central-part laryngectomy (CPL) or glottic closure, are preferable for patients with severe dysphagia and advanced respiratory impairment. 7,[9][10][11] A CPL removes the middle part of the thyroid cartilage and the entire cricoid cartilage while preserving the lateral aspect of the thyroid cartilage and epiglottis 10) (Fig. 1).…”