Choice of bronchoscopic intervention working channel for benign central airway stenosis

Chen, Hui; Zhang, Jie; Qiu, Xiaojian; Wang, Juan; Pei, Yinghua; Wang, Yuling; Wang, Ting

doi:10.1007/s11739-020-02531-9

Cited by 4 publications

(6 citation statements)

References 23 publications

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“…In recent years, the respiratory and critical care medicine, respiratory treatment technology, and lung transplantation and other operations have been rapidly developed and improved, resulting in an increased incidence of benign tracheal stenosis ( Chen et al, 2021 ). Although bronchoscopic intervention is a standard treatment for benign tracheal stenosis, it can cause secondary damage to the airway wall structure in some patients, and the excessive granulation tissue and scar contracture formed during the repair process will cause airway obstruction and force patients to undergo intervention therapy again, resulting in a vicious circle of “stenosis-treatment-repair-restenosis” ( Jeong et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Construction and Comprehensive Analysis of the ceRNA Network to Reveal Key Genes for Benign Tracheal Stenosis

Zou

Cai

2022

Front. Genet.

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Objective: To explore the possible biological functions of the differentially expressed genes in patients with benign tracheal stenosis, and to provide a valuable molecular basis for investigating the pathogenesis of benign tracheal stenosis.Method: Whole transcriptome sequencing was performed on blood samples collected from patients with benign tracheal stenosis and normal controls. Differentially expressed mRNA, lncRNA, and circRNA were analyzed using the DESeq2 package. The protein interaction networks for differentially expressed mRNAs were constructed by STRING. The results of gene co-expression network analysis, Starbase database prediction, and differential gene expression were combined to construct a competing endogenous RNA network. The transcription factors of key genes were predicted using the Network Analyst database and a transcription factor-mRNA regulatory network was constructed. The classical pathways, intermolecular interaction networks, and upstream regulatory components of key genes were analyzed using Ingenuity Pathway Analysis (IPA). Finally, the DGIDB database was used to predict the potential therapeutic drugs to target the identified key genes.Result: Based on mRNA, lncRNA and circRNA expression data, we found that differentially expressed mRNAs were enriched in oxygen transport, neutrophil activation, immune response, and oxygen binding. Then the pearson correlation between mRNAs of 46 key genes and lncRNAs and cricRNAs were calculated, and the correlation greater than 0.9 were selected to construct the co-expression network of “mRNA-lncRA” and “mRNA-cricRNA.” Moreover, a “lncRNA-miRNA-mRNA” network and a “circRNA-miRNA-mRNA” network were constructed. IPA analysis showed that the 46 key genes were significantly associated with inflammatory activation and acute respiratory distress syndrome. The constructed TF-mRNA regulatory network was composed of 274 nodes and 573 interacting pairs. 251 potential therapeutic drugs were identified from the DGIDB database.Conclusion: This study analyzed the differential genes associated with benign tracheal stenosis and explored the potential regulatory mechanisms, providing a scientific reference for further studies on the pathogenesis of benign tracheal stenosis.

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Section: Discussionmentioning

confidence: 99%

Construction and Comprehensive Analysis of the ceRNA Network to Reveal Key Genes for Benign Tracheal Stenosis

Zou

Cai

2022

Front. Genet.

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“…11 Because of these limitations, bronchoscopic interventions either through flexible, rigid, or a combined approach remain the cornerstone of the diagnosis and treatment of NMCAO and carry a lot of appeal. 5 Computed tomography is often useful to plan the bronchoscopic approach and dynamic modalities are often useful to visualize intermittent collapse during the expiratory phase of the breathing cycle. This dynamic component can be underestimated with static imaging modalities.…”

Section: Diagnosis and Treatmentmentioning

confidence: 99%

“…Among these therapeutic strategies, balloon dilation, high-frequency electrotome, argon plasma coagulation, cryotherapy, laser, and tracheal stents have been shown to rapidly improve luminal narrowing with a relatively low morbidity and lower incidence of adverse events. 5 Histologic determination of the involved stenotic region can appropriately categorize the pathophysiology of the NMCAO. Probe confocal microscopy and optical coherence tomography are two potential technologies that hold promise in being able to help determine the underlying pathophysiology.…”

Section: Simple Versus Complex and Inflammatory Versus Fibroticmentioning

confidence: 99%

Nonmalignant Central Airway Obstruction: Options for Challenging Cases

Abia‐Trujillo

Fernández-Bussy

2022

Semin Respir Crit Care Med

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Benign central airway obstruction is commonly referred as nonmalignant central airway obstruction (NMCAO). This is in part related to its lack of benign nature and significant life-quality impairment in patients. It is a pathologic entity with various etiologies and therefore a wide range of therapeutic options are available. Evidence regarding the optimal management that could provide a sustained restoration of airway patency is lacking. The lack of a common pathophysiologic pathway translating into a nonspecific symptom presenting as NMCAO has complicated treatment standardization and subsequently limited solid research to favor of one approach over another one. Our intent is to describe the limited evidence of the most utilized nonsurgical treatment for NMCAO as well as some upcoming promising therapeutic options such as mitomycin C injection, microdebrider, biodegradable stents, radiotherapy, Hybrid Knife, and endoluminal spray cryotherapy. Our goal with this manuscript is to motivate other authors to venture into prospective, multicenter, open-label trials aimed to describe long-term outcomes in patients with NMCAO.

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“…Over the years, CFD studies of central and lower airway have gained extensive research attention both experimentally and numerically as medical practitioners seek to understand the underlying mechanics of diseases in the human airway tract. Of both central and lower airways, conditions pertaining to the lower airways are more difficult to diagnose [80,81]. Construction of accurate geometry of the entire airway generation is also a complex work because obtaining scan based models is presently limited to the mouth cavity and a few lower airway generations.…”

Section: Cfd In Reduced Lower Airway Modelsmentioning

confidence: 99%

“…A CFD approach in the investigation of the lower airways will typically involve some assumptions, boundary conditions and governing equations that have been established as simple and feasible standards over time in specifying the velocity inlet and outlet (see [81,90,91,52,[92][93][94]. Generally speaking, studies of the lower airways typically apply a laminar profile at the trachea, which is the point of delineation between the extra-thoracic airway (ETA) and the lower airways [95][96][97].…”

Section: Cfd In Reduced Lower Airway Modelsmentioning

confidence: 99%

Computational Fluid Dynamics Modeling in Respiratory Airways Obstruction: <i>Current Applications and Prospects</i>

Ayodele¹,

Oluwatosin²,

Taiwo³

et al. 2021

IJBSE

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Breathing conditions pertaining to nasal obstruction, obstructive sleep apnea, and airflow resistance in the human lower airways have been investigated extensively by researchers over the years. Due to the availability of advanced computer numerical models, such as computational fluid dynamics (CFD), researchers have made progressive studies of airflow characteristic, especially the effects of airflow pressure, velocity and wall shear stress in human obstructive airways. Studies utilizing CFD have enhanced clinical understanding of the physiology and pathophysiology of the respiratory system through the concept of three-dimensional models that facilitate airflow simulation. The main objective of this article is to review recent CFD literature on nasal airflow and lower airway obstruction. The review covers the role of segmentation threshold in the outcome of airflow simulation in the nasal cavity, and results of fluid structure interaction (FSI) and computational fluid dynamics in nasal obstruction and airway collapse in obstructive sleep apnea were also correlated. For models of the lower airways, we evaluated the effect of extra-thoracic airway (ETA) on downstream airflow during simulation against the popular Weibel's model. In the concluding section, we discussed the advantages, limitations, and prospects (precisely with deep machine learning) of computational fluid dynamics in the clinical assessment and investigation of respiratory diseases.

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Choice of bronchoscopic intervention working channel for benign central airway stenosis

Cited by 4 publications

References 23 publications

Construction and Comprehensive Analysis of the ceRNA Network to Reveal Key Genes for Benign Tracheal Stenosis

Construction and Comprehensive Analysis of the ceRNA Network to Reveal Key Genes for Benign Tracheal Stenosis

Nonmalignant Central Airway Obstruction: Options for Challenging Cases

Computational Fluid Dynamics Modeling in Respiratory Airways Obstruction: <i>Current Applications and Prospects</i>

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Choice of bronchoscopic intervention working channel for benign central airway stenosis

Cited by 4 publications

References 23 publications

Construction and Comprehensive Analysis of the ceRNA Network to Reveal Key Genes for Benign Tracheal Stenosis

Construction and Comprehensive Analysis of the ceRNA Network to Reveal Key Genes for Benign Tracheal Stenosis

Nonmalignant Central Airway Obstruction: Options for Challenging Cases

Computational Fluid Dynamics Modeling in Respiratory Airways Obstruction: &lt;i&gt;Current Applications and Prospects&lt;/i&gt;

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Computational Fluid Dynamics Modeling in Respiratory Airways Obstruction: <i>Current Applications and Prospects</i>