Choices in Surgery for Older Women with Breast Cancer

Swaminathan, Vikram; Spiliopoulos, M.K.; Audisio, Riccardo A.

doi:10.1159/000345402

Cited by 3 publications

(3 citation statements)

References 60 publications

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“…Breast cancer is a major cause of mortality in the current world population ( 24 ). CD8 T cells have been considered to play a central role in immunotherapy ( 25 ).…”

Section: Discussionmentioning

confidence: 99%

Construction of ceRNA Networks Associated With CD8 T Cells in Breast Cancer

et al. 2022

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BackgroundThe infiltration of CD8 T cells is usually linked to a favorable prognosis and may predict the therapeutic response of breast cancer patients to immunotherapy. The purpose of this research is to investigate the competing endogenous RNA (ceRNA) network correlated with the infiltration of CD8 T cells.MethodsBased on expression profiles, CD8 T cell abundances for each breast cancer (BC) patient were inferred using the bioinformatic method by immune markers and expression profiles. We were able to extract the differentially expressed RNAs (DEmRNAs, DEmiRNAs, and DElncRNAs) between low and high CD8 T-cell samples. The ceRNA network was constructed using Cytoscape. Machine learning models were built by lncRNAs to predict CD8 T-cell abundances. The lncRNAs were used to develop a prognostic model that could predict the survival rates of BC patients. The expression of selected lncRNA (XIST) was validated by quantitative real-time PCR (qRT-PCR).ResultsA total of 1,599 DElncRNAs, 89 DEmiRNAs, and 1,794 DEmRNAs between high and low CD8 T-cell groups were obtained. Two ceRNA networks that have positive or negative correlations with CD8 T cells were built. Among the two ceRNA networks, nine lncRNAs (MIR29B2CHG, NEAT1, MALAT1, LINC00943, LINC01146, AC092718.4, AC005332.4, NORAD, and XIST) were selected for model construction. Among six prevalent machine learning models, artificial neural networks performed best, with an area under the curve (AUC) of 0.855. Patients from the high-risk category with BC had a lower survival rate compared to those from the low-risk group. The qRT-PCR results revealed significantly reduced XIST expression in normal breast samples, which was consistent with our integrated analysis.ConclusionThese results potentially provide insights into the ceRNA networks linked with T-cell infiltration and provide accurate models for T-cell prediction.

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“…Breast cancer is a major cause of mortality in the current world population ( 24 ). CD8 T cells have been considered to play a central role in immunotherapy ( 25 ).…”

Section: Discussionmentioning

confidence: 99%

Construction of ceRNA Networks Associated With CD8 T Cells in Breast Cancer

et al. 2022

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“…The United Nations has no standard numerical criterion for 'elderly'. However, the U.N. agreed cut-off is 60+ years of age when referring to the older population (Swaminathan & Audisio, 2012). In Malaysia, the elderly are defined as those who are 60 years old and above.…”

Section: Older People In Malaysiamentioning

confidence: 99%

Exploring Challenges in Walking Frame Use Among the Elderly: A Study in Klang Valley, Malaysia

Hussain,

Ibrahim,

Md. Yusuff

et al. 2024

MAJCAFE

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The elderly utilize a walking frame to address deficiencies in balance, coordination, strength, and the risk of falling during walking. Despite previous research highlighting the advantages and benefits of walking frame use for this demographic, some individuals have encountered various issues concerning its use. Thus, this study aims to explore issues of walking frame use among the elderly in Klang Valley, Malaysia. A total of 30 participants of community-dwelling elderly aged 60 and above in Selangor and Kuala Lumpur who are current and former walking frame users and were selected via purposive sampling, were involved in this study. This study utilized the qualitative approach using semi-structured questions. Interview data in the form of verbatim transcripts were analyzed thematically. The majority of respondents were female with a mean age of 71.7 years old, (SD=8.06), Malay, married, primary education level, retirees, living with a spouse and children and staying in Selangor. On the health aspect, the majority of them had hypertension and Body Mass Index (BMI) was pre-obese (25.0 – 29.9 kg/m2). In terms of walking frame usage, most respondents used a standard walking frame (without wheels), used a walking frame for 1 year or less, purchased it by themselves or through family members, indoor usage and reason for use because of leg weakness due to injury. Thematic analysis results show that there were several issues identified such as the respondents’ physical and psychological condition, as well as walking frame issues on quality, design, use and cost. Furthermore, issues concerning the physical environment of the home were reported. It is hoped that these findings can serve as a reference for relevant parties to further explore aspects related to the use, product development, and management of physical environments concerning walking frames.

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“…In the past, elderly with breast cancer frequently underwent conservative treatment only for breast cancer. Although breast cancer grows more slowly and has a better prognosis in elderly [4,5], many studies have suggested that they should be managed actively [6][7][8][9][10]. However, the comorbidities of elderly may hinder implementation of active forms of treatment.…”

Section: Introductionmentioning

confidence: 99%

Oncologic Results of Breast Conserving Surgery under Procedural Sedation in Elderly Patients

et al. 2019

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Purpose: Although surgery is the most frequently implemented treatment modality for breast cancer, many older patients with breast cancer are under-or untreated because of their high incidence of postoperative complications. We assessed the efficacy and safety of breast surgery under procedural sedation in older patients (aged > 70 years) by comparing selected clinical and oncologic factors after surgery for breast cancer under general anesthesia versus procedural sedation. Methods: Of 79 older patients with breast cancer, 49 underwent breast-conserving surgery, 30 under general anesthesia and 19 under procedural sedation, and relevant clinical and oncologic variables were compared and analyzed between groups. Results: The mean age was younger in the general anesthesia group and the mean operation time, hospital stay, and fasting time shorter in the procedural sedation group. There were no statistically significant differences in oncologic results between the two groups during follow-up. Conclusion: Breast surgery under procedural sedation is a safe and effective means of reducing tumor burden in older patients with breast cancer when their American Society of Anesthesiologists (ASA) physical status indicates a high risk of life-threatening perioperative complications associated with general anesthesia. And we also found that the oncologic results may be not inferior to same procedure under general anesthesia.

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Choices in Surgery for Older Women with Breast Cancer

Cited by 3 publications

References 60 publications

Construction of ceRNA Networks Associated With CD8 T Cells in Breast Cancer

Construction of ceRNA Networks Associated With CD8 T Cells in Breast Cancer

Exploring Challenges in Walking Frame Use Among the Elderly: A Study in Klang Valley, Malaysia

Oncologic Results of Breast Conserving Surgery under Procedural Sedation in Elderly Patients

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