Cholangiocarcinoma in Primary Sclerosing Cholangitis: Risk Factors and Clinical Presentation

Boberg, Kirsten Muri; Bergquist, Annika; Mitchell, Stephen; Pares, A.; Rosina, F.; Broomé, Ulrika; Chapman, Roger W.; Fausa, O; Egeland, Torstein; Rocca, Giuseppe; Schrumpf, E.

doi:10.1080/003655202760373434

Cited by 277 publications

(215 citation statements)

References 27 publications

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“…Primary sclerosing cholangitis, with or without associated inflammatory bowel disease, predisposes to the development of CC in about 12% of patients. 32 Other reported associations with less definite pathogenetic significance include alcohol consumption, anabolic and contraceptive steroid use, genetic hemochromatosis, alpha-1-antitrypsin deficiency, extrahepatic biliary atresia, and Thorotrast exposure. 1 …”

Section: Etiologymentioning

confidence: 99%

Neoplasms of the liver

2007

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Section: Etiologymentioning

confidence: 99%

Neoplasms of the liver

2007

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“…PSC predisposes to the development of CC in about 12% of patients [37]. In PSC the anti-apoptotic protein Mcl-1 is strongly expressed in bile duct epithelial cells through the action of the IL6/AKT survival signaling pathway [38], suggesting the presence of an apoptosis resistant field.…”

Section: Bile Duct Cancer (Cholangiocarcinoma)mentioning

confidence: 99%

Field defects in progression to gastrointestinal tract cancers

Bernstein

Payne

et al. 2008

Cancer Letters

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A field of defective tissue may represent a pre-malignant stage in progression to many cancers. However, field defects are often overlooked in studies of cancer progression through assuming tissue at some distance from the cancer is normal. We indicate, however, the generality of field defects in gastrointestinal cancers, including cancers of the oropharynx, esophagus, stomach, bile duct, pancreas, small intestine and colon/rectum. Common features of these field defects are reduced apoptosis competence, aberrant proliferation and genomic instability. These features are often associated with high bile acid exposure and may explain the association of dietary-related factors with cancer progression.

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“…Patients with PSC have a 100-fold higher risk of biliary tumors, when compared to the general population, with a reported prevalence of 5%-15% (238)(239)(240)(241)(242)(243) . The most common type of cancer is CC.…”

Section: Screening and Management Of Cholangiocarcinomamentioning

confidence: 99%

“…The most common type of cancer is CC. Half of the cases of CC are reported in the first year after the diagnosis of PSC (239,241) . Patients with concurrent IBD are at increased risk for CC.…”

Section: Screening and Management Of Cholangiocarcinomamentioning

confidence: 99%

Brazilian society of hepatology recommendations for the diagnosis and management of autoimmune diseases of the liver

Bittencourt

Cançado

Couto

et al. 2015

Arq. Gastroenterol.

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-In order to draw evidence-based recommendations concerning the management of autoimmune diseases of the liver, the Brazilian Society of Hepatology has sponsored a single-topic meeting in October 18th, 2014 at São Paulo. An organizing committee comprised of seven investigators was previously elected by the Governing Board to organize the scientific agenda as well as to select twenty panelists to make a systematic review of the literature and to present topics related to the diagnosis and treatment of autoimmune hepatitis, primary sclerosing cholangitis, primary biliary cirrhosis and their overlap syndromes. After the meeting, all panelists gathered together for the discussion of the topics and the elaboration of those recommendations. The text was subsequently submitted for suggestions and approval of all members of the Brazilian Society of Hepatology through its homepage. The present paper is the final version of the reviewed manuscript organized in topics, followed by the recommendations of the Brazilian Society of Hepatology.

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Cholangiocarcinoma in Primary Sclerosing Cholangitis: Risk Factors and Clinical Presentation

Abstract: A high proportion of CC cases is diagnosed within the first year after diagnosis of PSC. A long history of inflammatory bowel disease is a risk factor for CC development.

Cited by 277 publications

References 27 publications

Neoplasms of the liver

Neoplasms of the liver

Field defects in progression to gastrointestinal tract cancers

Brazilian society of hepatology recommendations for the diagnosis and management of autoimmune diseases of the liver

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