Cholangiocarcinoma of intrahepatic bile ducts with disseminated metastases in a Siamese cat: a case report

Aslan, Öznur; Çakir, Latife; Bekdik, İlknur Karaca; Doğan, Zafer; Tunç, Arda Selin

doi:10.17221/7624-vetmed

Cited by 7 publications

(13 citation statements)

References 26 publications

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“…Biliary duct carcinomas are firm, elevated, non--encapsulated, have a central umbilicated-like depression, and multiple whitish nodules [1,2,[5][6][7], similar to that observed in cat 1. Evaluation of cat 2 revealed tumors with the same consistency, but presented as masses of large sizes, covering almost all the hepatic parenchyma.…”

Section: Discussionmentioning

confidence: 63%

“…According to the authors' knowledge, this is the second report of cholangiocarcinoma in young cats, with only one study evidencing the presence of such neoplasia in a 4-year-old cat [2].…”

Section: Discussionmentioning

confidence: 75%

“…The clinical signs of cats with hepatobiliary neoplasms include apathy, lethargy, weakness, hyporexia, anorexia, weight loss, vomiting, diarrhea, polydipsia, ascites, abdominal distention, jaundice, and dyspnea [2,5,6,8].…”

Section: Discussionmentioning

confidence: 99%

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Cholangiocarcinoma in Young Cats

Jardim

Cid

Oliveira

et al. 2019

Acta Scientiae. Vet.

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Background: Cholangiocellular carcinoma is a malignant tumor that occurs mainly in elderly dogs and cats. Primary hepatobiliary neoplasms are considered rare in felines, although cholangiocarcinoma is the most common tumor type among malignant liver tumors in the species. The objective of this work is to report two cases of cholangiocarcinoma in young domestic cats, with three years old, and to approach clinical and pathological aspects to promote awareness of this type of injury in young animals, with a focus on prevention of predisposing factors. Cases: A 3-year-old male domestic cat (cat 1) had a history of progressive weight loss, persistent vomiting, diarrhea, and episodes of seizure. At the clinical examination was noted moderate degree of jaundice. In the biochemical exams it was verified as alteration hypoproteinemia, increase of urea and hyponatremia. Abdominal ultrasonography revealed a formation in the left epigastric region measuring 8.0 x 5.0 cm, with a diffusely heterogeneous parenchyma, suggestive of hepatic neoplasia, in addition to the presence of free abdominal fluid. Cavity fluid analysis was suggestive of carcinoma. A 3-year-old male domestic cat (cat 2), with history of hyporexia, emaciation and vomiting was taken to care. Physical examination showed moderate dehydration, hypocorous mucosa and presence of abdominal mass on palpation. The animal's serum biochemical assessment were verified as changes, increasing AST. Ultrasonographic examination showed an abdominal mass, located caudally to the spleen, with irregular shape, measuring approximately 4.7 cm suggestive of hepatic neoplasia, in addition to the presence of abdominal fluid. The hepatic cytology performed by fine needle aspiration was suggestive of carcinoma. After the clinical worsening of two cats and due unfavorable prognosis, euthanasia and necropsy were performed. In the macroscopic analysis of cat 1, numerous nodules of whitish and sometimes "umbilicate" coloration were observed in the liver, measuring up to three cm in diameter, distributed randomly by the hepatic parenchyma and with a soft consistency at cut. An ovoid-wicking mass, measuring 6.0 x 7.0 x 5.0 cm and coloring ranging from white to light brown was checked in omentum. In the macroscopic evaluation of cat 2, numerous coalescing masses of whitish coloring measuring up to 6.0 cm in diameter were observed covering almost every hepatic parenchyma and also affecting the pancreas, with a soft consistency at cut. The microscopic findings of both cats were compatible with the diagnosis of cholangiocarcinoma. Considering the immunohistochemical profile, in both cases there was positivity for the CK Pan antibody and CEA and negativity for the CK20, TTF-1, Hepatocyte specific antigen, CD10 and CD56 antibodies. Discussion: Cholangiocarcinomas usually occur in elderly animals, with a mean age of 9 years, so it may be suggested that the cause of the disease in cat 1 and 2 was possibly related to the early and continuous presence of carcinogens. The biliary duct trematod Platynoso...

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Section: Discussionmentioning

confidence: 63%

“…According to the authors' knowledge, this is the second report of cholangiocarcinoma in young cats, with only one study evidencing the presence of such neoplasia in a 4-year-old cat [2].…”

Section: Discussionmentioning

confidence: 75%

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Cholangiocarcinoma in Young Cats

Jardim

Cid

Oliveira

et al. 2019

Acta Scientiae. Vet.

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“…It rarely produces spontaneous rupture and haemoabdomen, 9 and it has been associated with the trematode Clonorchis sinensis in humans, as well as with chronic exposure to different toxic agents. 1 The case described here was a 14-year-old female Persian-crossed cat, without previous history of toxic exposure. Metastases were observed within the lung and peritoneum, which produced an exudative effusion in the abdomen secondary to the carcinomatosis.…”

Section: Discussionmentioning

confidence: 99%

“…There is no apparent breed or sex predisposition, although it is commonly found in animals older than 10 years of age. 1…”

Section: Introductionmentioning

confidence: 99%

Cholangiocarcinoma and hepatic myelolipoma incarcerated in a peritoneopericardial diaphragmatic hernia with pulmonary metastasis and carcinomatosis in a cat

Barge

Sebastián-Marcos

Martı́nez

et al. 2019

Journal of Feline Medicine and Surgery Open Reports

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Case summary A 14-year-old female neutered Persian-cross cat was presented with a 1 week history of anorexia and lethargy. On physical examination, marked tachypnoea and dyspnoea were evident. Radiographs of the thorax revealed a globoid-shaped cardiac silhouette with heterogeneous opacity consistent with a peritoneopericardial diaphragmatic hernia (PPDH), pulmonary nodules compatible with metastasis, seven sternal segments and a small liver in the cranial abdomen with loss of serosal detail. On echocardiography, there was no evidence of cardiac tamponade. Triple-phase CT angiography demonstrated a mixed soft tissue-, mineral- and fat-attenuated liver mass arising from the left hepatic lobes that showed a pronounced heterogeneous contrast-enhancement pattern within the pericardial sac, which was producing a marked mass effect on the adjacent structures. Additionally, there was an increase in attenuation of the mesenteric fat and peritoneal effusion. The pulmonary nodules were confirmed. Imaging findings were compatible with a malignant hepatic neoplasia incarcerated in a PPDH, lung metastasis and carcinomatosis. Owing to the poor prognosis, the cat was humanely euthanased. Histopathological diagnosis was cholangiocellular carcinoma and hepatic myelolipoma, pulmonary metastasis and carcinomatosis. Relevance and novel information Hepatic cholangiocarcinoma incarcerated in a PPDH with pulmonary metastasis and carcinomatosis has not been previously described. Suspicion of a hepatic neoplasia should be raised in cases of PPDH and pulmonary nodules.

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End‐to‐end anastomosis of the common bile duct and cholecystoduodenostomy for the treatment of extrahepatic cholangiocarcinoma in an 11‐year‐old cat

Jifcovici

Caraty²,

Vincken³

et al. 2021

Vet Record Case Reports

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An 11-year-old cat presented with a 10-day history of anorexia and jaundice. Diagnostic examinations showed hyperbilirubinemia, dilatation of the bile ducts and a mural mass in the common bile duct. Cholecystoduodenostomy, mass resection and end-to-end anastomosis of the common bile duct were performed. Histopathology revealed a well-differentiated cholangiocarcinoma. The cat improved clinically and had a good quality of life for 16 months prior to disease recurrence. Liver biopsy indicated metastasis of the primary tumour. Euthanasia was elected. Cholangiocarcinoma in cats is considered to have a poor prognosis with high rate of metastasis. Given the paucity of information in the veterinary literature and the lack of specific prognostic indicators, guidelines for feline cholangiocarcinoma management have not been fully established. This clinical case report describes an acceptable outcome after tumour resection and biliary diversion in an 11-year-old cat with extrahepatic cholangiocarcinoma and no pre-existing metastases. INVESTIGATIONSAbdominal ultrasound (US) indicated severe generalized hepatomegaly with multiple tubular/round, anechoic structures

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Cholangiocarcinoma of intrahepatic bile ducts with disseminated metastases in a Siamese cat: a case report

Cited by 7 publications

References 26 publications

Cholangiocarcinoma in Young Cats

Cholangiocarcinoma in Young Cats

Cholangiocarcinoma and hepatic myelolipoma incarcerated in a peritoneopericardial diaphragmatic hernia with pulmonary metastasis and carcinomatosis in a cat

End‐to‐end anastomosis of the common bile duct and cholecystoduodenostomy for the treatment of extrahepatic cholangiocarcinoma in an 11‐year‐old cat

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