1981
DOI: 10.1097/00000658-198103000-00016
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Cholangitis due to Malignant Obstruction of Biliary Outflow

Abstract: This study reports the clinical presentation and hospital course of 21 patients with cholangitis and malignant diseases, obstructing the biliary tree. Eleven of 21 patients had cholangitis as the initial presentation of biliary disease, and the diagnosis of carcinoma was made at operation or autopsy examination. A total of 14 patients with cholangitis had no prior biliary surgery. Patients who underwent operations to relieve biliary obstructions during episodes of cholangitis had greater incidences of resoluti… Show more

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Cited by 33 publications
(8 citation statements)
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“…In patients with different biliary tract problems, positive bile cultures are most commonly found in those patients with common duct stones or carcinoma of the ampulla, which produces intermittent obstruction to bile flow (9). Cholangitis is not frequently found in tumors obstructing the common bile duct (10,11). The b e d obstruction presumably prevents the ascent of bacteria from the duodenum.…”
Section: Discussionmentioning
confidence: 99%
“…In patients with different biliary tract problems, positive bile cultures are most commonly found in those patients with common duct stones or carcinoma of the ampulla, which produces intermittent obstruction to bile flow (9). Cholangitis is not frequently found in tumors obstructing the common bile duct (10,11). The b e d obstruction presumably prevents the ascent of bacteria from the duodenum.…”
Section: Discussionmentioning
confidence: 99%
“…However, locoregional invasion to surrounding vital structures such as the hepatic artery and portal vein, as well as the presence of distant metastasis, contraindicates surgical resection 14. Because high bile duct obstruction caused by hilar cholangiocarcinoma and gallbladder carcinoma leads to sepsis and cholangitis, resulting in progressive liver failure and death,9,10 the majority of patients with nonresectable disease require an effective palliative procedure to relieve jaundice. There is considerable debate as to which procedure provides the best palliation, among biliary enteric bypass, percutaneous transhepatic endoprostheses, and placement of a metallic stent .…”
Section: Discussionmentioning
confidence: 99%
“…However, resectability rates for these diseases are low because of local invasion to surrounding vascular systems, such as the hepatic artery and portal vein, and metastases to regional lymph nodes and viscera . Under these conditions, the primary objective in the majority of patients is to relieve obstructive jaundice through appropriate treatment modalities, because malignant biliary obstruction results in cholangitis, sepsis, and subsequent liver failure 9,10. Obstruction of the extrahepatic bile duct because of incurable malignancy challenges surgeons to achieve satisfactory relief of jaundice and maximize life expectancy while incurring minimal risk to the patient.…”
Section: Introductionmentioning
confidence: 99%
“…85. 98] although oth ers reported nearly 40% [92,99], The finding that partial rather than total obstruction is better correlated to bactibilia [84,85,100. 101] was further qualified in an extensive Japanese study [86] of 295 patients undergoing percutaneous transhepatic chol angiography, including 70 patients with var ious biliary tract malignancies.…”
Section: Bactibilia Related To Clinical Features Of Common Duct Disordermentioning
confidence: 99%