Cholecalciferol significantly increases 25-hydroxyvitamin D concentrations in adults with cystic fibrosis

Stephenson, Anne L.; Brotherwood, Michelle; Robert, Ronalee; Atenafu, Eshetu G; Corey, Mary; Tullis, Elizabeth

doi:10.1093/ajcn/85.5.1307

Cited by 82 publications

(79 citation statements)

References 18 publications

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“…Most of them had suboptimal serum 25OHD concentration. This finding is in line with studies of other CF patient populations (Rovner et al, 2007;Stephenson et al, 2007;Neville and Ranganathan, 2009). With supplementation or UV-B exposure, 25OHD could, however, be safely increased over time (Stephenson et al, 2007;Khazai et al, 2009;Neville and Ranganathan, 2009 …”

Section: Discussionsupporting

confidence: 89%

“…Most CF patients have suboptimal serum levels of 25-hydroxyvitamin D (25OHD) (below 75 nmol/l), despite following the currently recommended vitamin D supplementation regimens (Rovner et al, 2007;Stephenson et al, 2007). Literature review indicates that vitamin D status of CF populations may have been improving over the last 15 years, but mean 25OHD serum concentration continues to be suboptimal (Hall et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Inverse relation between vitamin D and serum total immunoglobulin G in the Scandinavian Cystic Fibrosis Nutritional Study

Pincikova

Nilsson²,

Moen³

et al. 2010

Eur J Clin Nutr

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Background/Objectives: The hallmark of cystic fibrosis (CF) is chronic lung inflammation. The severity of lung disease is closely correlated with immunoglobulin G (IgG) levels. Beyond its contribution to the bone health, the importance of vitamin D has not been fully recognized owing to the lack of human studies providing evidence of its benefit. In the context of the recently described immunomodulatory functions of vitamin D, we aimed to assess the relationship between vitamin D and IgG levels. Subjects/Methods: Eight hundred and ninety-six CF patients were included (0.53-65.9 years) from seven centers in Denmark, Norway and Sweden. Serum 25-hydroxyvitamin D (25OHD) and total IgG were measured, spirometry was carried out and vitamin D intake data were gathered using a 7-day dietary food record. Multiple linear regression analyses were performed for IgG and forced expiratory volume in 1ls (FEV1) as dependent variables, and serum 25OHD, daily food and supplemented vitamin D sources of intake as independent variables. The model was controlled for age, gender, genotype, CF-related diabetes, season, infection/colonization status, long-term oral corticosteroid treatment, long-term treatment with macrolide antibiotics, pancreatic insufficient phenotype and body mass index z-score. Results: Serum total IgG levels were negatively associated with serum 25OHD (adjusted R 2 ¼ 0.376; beta ¼ À0.02; Po0.001), supplemented vitamin D intake per kg bodyweight (adjusted R 2 ¼ 0.375; beta ¼ À0.82; Po0.001) and total vitamin D intake per kg bodyweight (adjusted R 2 ¼ 0.398; beta ¼ À0.60; P ¼ 0.002). Serum 25OHD was positively associated with FEV1 (adjusted R 2 ¼ 0.308; beta ¼ 0.0007; P ¼ 0.025). Conclusions: Increasing vitamin D intake may positively modulate inflammation in CF. This study supports the proposed role of vitamin D in the immune system during infection and substantiates prospective studies.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Inverse relation between vitamin D and serum total immunoglobulin G in the Scandinavian Cystic Fibrosis Nutritional Study

Pincikova

Nilsson²,

Moen³

et al. 2010

Eur J Clin Nutr

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show abstract

“…The majority of children and adults with cystic fibrosis worldwide are vitamin D insufficient, irrespective of their exocrine pancreatic function [4][5][6][7]. However, there is as yet no evidence for a benefit of vitamin D supplementation in cystic fibrosis, not even for bone health [8].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D deficiency as a risk factor for cystic fibrosis-related diabetes in the Scandinavian Cystic Fibrosis Nutritional Study

et al. 2011

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Aims/hypothesis Many cystic fibrosis patients are vitamin D-insufficient. Cystic fibrosis-related diabetes is a major complication of cystic fibrosis. The literature suggests that vitamin D might possess certain glucose-lowering properties. We aimed to assess the relationship between vitamin D and cystic fibrosis-related glucose intolerance. Methods We enrolled 898 cystic fibrosis patients from Sweden, Norway and Denmark. Vitamin D intake was assessed using a seven-day food record. Serum 25-hydroxyvitamin D (s25OHD) and HbA 1c were measured, and an OGTT was carried out. Multiple linear and logistic regressions were used for HbA 1c and cystic fibrosis-related diabetes/OGTT result as outcome variables, respectively. Each model was controlled for country, and for known cystic fibrosis-related diabetes risk factors: age, sex, genotype, liver dysfunction, long-term corticosteroid treatment, and lung and pancreatic function. Results Degree of vitamin D insufficiency (OR 1.36; p=0.032) and s25OHD<30 nmol/l (OR 1.79; p=0.042) were significant risk factors for cystic fibrosis-related diabetes. Accordingly, HbA 1c value was positively associated with s25OHD< 30 nmol/l and<50 nmol/l, as well as with degree of vitamin D insufficiency (adjusted R 2 =20.5% and p<0.05 in all).Electronic supplementary material The online version of this article

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“…Studies on vitamin D and lung function in the CF population are lacking. Most studies focus on prevalence of vitamin D deficiency, supplementation, and bone health but comment on lung function as a possible predictor of vitamin D deficiency (22)(23)(24). These studies have had conflicting results, with only one study reporting a significant positive relationship between 25-OHD level and pulmonary function (23).…”

mentioning

confidence: 99%

Vitamin D Deficiency Is Associated with Pulmonary Exacerbations in Children with Cystic Fibrosis

et al. 2014

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Rationale: Recent literature suggests vitamin D has an effect on lung function and on the lung's ability to fight infection, both important in the cystic fibrosis (CF) population as predictors of morbidity and mortality.Objectives: Our study assessed associations between vitamin D and % predicted lung function, pulmonary exacerbations, and first Pseudomonas aeruginosa infection in children with CF. We hypothesized that children with CF who have 25-hydroxy vitamin D (25-OHD) levels less than 30 mg/L would have lower % predicted lung function and more pulmonary exacerbations than those with 25-OHD greater than or equal to 30 mg/L. Measurements and Main Results:The prevalence of vitamin D deficiency and insufficiency increased slowly through adolescence. The rate of exacerbations for the deficient vitamin D group, aged 15 to 18 years, was 13.1 per 10 patient-years, significantly higher than 4.3 per 10 patient-years for the insufficient and sufficient vitamin D groups (P , 0.05), which were not significantly different There were no differences between vitamin D groups in pulmonary function or incidence of first P. aeruginosa infection, which was about 2 per 10 patient-years.Conclusions: Higher 25-OHD levels in children with CF were associated with lower rates of pulmonary exacerbations and, in adolescents, higher FEV 1 .

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Cholecalciferol significantly increases 25-hydroxyvitamin D concentrations in adults with cystic fibrosis

Abstract: A significant proportion of adults with cystic fibrosis have serum 25(OH)D concentrations

Cited by 82 publications

References 18 publications

Inverse relation between vitamin D and serum total immunoglobulin G in the Scandinavian Cystic Fibrosis Nutritional Study

Inverse relation between vitamin D and serum total immunoglobulin G in the Scandinavian Cystic Fibrosis Nutritional Study

Vitamin D deficiency as a risk factor for cystic fibrosis-related diabetes in the Scandinavian Cystic Fibrosis Nutritional Study

Vitamin D Deficiency Is Associated with Pulmonary Exacerbations in Children with Cystic Fibrosis

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