Cholecystectomy and the risk of alimentary tract cancers: A systematic review

Coats, Maria; Shimi, S. M.

doi:10.3748/wjg.v21.i12.3679

Cited by 30 publications

(27 citation statements)

References 103 publications

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“…However, most of the previous studies adjusted only for age and sex [10]. In our current study, we adequately adjusted for additional important confounding factors such as obesity, diabetes, and family history.…”

Section: Discussionmentioning

confidence: 99%

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Cholecystectomy and the risk of colorectal cancer by tumor mismatch repair deficiency status

Jie

Reece

Buchanan

et al. 2016

Int J Colorectal Dis

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Purpose Gallbladder diseases and cholecystectomy may play a role in the development of colorectal cancer (CRC). Our aim was to investigate the association between cholecystectomy and CRC risk overall and by sex, family history, anatomical location, and tumor mismatch repair (MMR) status. Methods This study comprised 5,847 incident CRC cases recruited from population cancer registries in Australia, Canada and USA into the Colon Cancer Family Registry between 1997 and 2012, and 4,970 controls with no personal history of CRC who were either randomly selected from the general population or were spouses of the cases. The association between cholecystectomy and CRC was estimated using logistic regression, after adjusting for confounding factors. Results Overall, there was no evidence for an association between cholecystectomy and CRC (odds ratio [OR] = 0.88, 95% confidence interval: 0.73, 1.08). In the stratified analyses, there was no evidence for a difference in the association between women and men (P=.54), between individuals with and without family history of CRC in first-degree relative (P=.64), between tumor anatomical locations (P=.45), or between MMR-proficient and MMR-deficient cases (P=.54). Conclusion Cholecystectomy is not a substantial risk factor for CRC, regardless of sex, family history, anatomical location, or tumor MMR status.

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Section: Discussionmentioning

confidence: 99%

“…Further, risks may be differentially associated with cancer at different anatomical locations within the colon [10]. No previous studies have examined the association between cholecystectomy and CRC according to their tumor mismatch repair (MMR) status.…”

Section: Introductionmentioning

confidence: 99%

Cholecystectomy and the risk of colorectal cancer by tumor mismatch repair deficiency status

Jie

Reece

Buchanan

et al. 2016

Int J Colorectal Dis

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“…It was found that 32 patients had prior cholecystectomy [8]. Smoking was other finding found in 110 patients, which is found as risk factor in other studies [9] 2) Positive diagnosis between imaging modalities CT/MRI = 48% [14].…”

Section: Resultsmentioning

confidence: 62%

“…Prior cholecystectomy was present in17 patient (20%) [8]. 3) Positivity between diagnostic imaging modalities MRI/CT = 57% [8].…”

mentioning

confidence: 99%

MRI and CT into Pathology Tumor and Liver Bile Duct

Gjonbalaj¹,

Hoxhaj²,

Gjonbalaj³

et al. 2017

OJRad

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Background: Tumor pathologies of the liver and bile ducts are relatively commonly diagnosed and the primary goal is to differentiate these lesions in the fastest possible time which determines the apropriate method of treatment. Aims and Objectives: Aim of this study is tracking and diagnostic imaging correlation of tumor pathologies of liver and bile ducts and determining the early diagnostic approach. Data obtained from this study are important for treatment procedures and succes of treatment. All cases with liver tumor pathologies from period 2012-2016 were examined with CT and MRI followed by other complementary imaging methods. Methods: CT examination was performed according to standard triple-phase protocol: non-enhanced phase, arterial phase and porto-venous phase, and in some cases with late phase after 5 minutes. In MRI examinations, standard protocol was performed: coronal T2 single-shot fast spin-echo (coronal T2 SSFs), Axial T2 respiratory-triggered fast spin-echo (axial T2-FRE)/or breath-hold fast-recovery fast spin-echo T2 body coil sizes XL, (axial T2-FRFSE-XL), Axial in-phase/out-of-phase, Axial/ coronal three-dimensional liver acquisition with volume acceleration (3D coronal pre lava). Results: For comparation, only patients with liver focal lesions were included in the study, and and patient were examined with both diagnostic imaging modalities (CT and MRI). 168 patients with liver tumor pathologies and biliary tree tumor pathologies are included in the study. Gender ratio was 85 males and 83 female (M/F ratio 1.03:1). Average age of patients was 58.41 years, (minimum age 1.5 years old and maximum 88 years of age). The most frequent age on diagnosis was 61 -70 years (total of 49 patients or 29.16%). Benign tumors were found with 93 patients (55.35%) and malignant tumors in 79 patients (47.02%). Distribution in liver parenchyma How to cite this paper: Gjonbalaj, N., Hoxhaj, A., Gjonbalaj, E., Biçaku, A., Kutllovci, A., Nuza, S. and Hyseni, B. was found in 113 patients (67.26%), while in 49 patients (29.17%) pathology was found in the biliary tract. The most affected liver segment was the fifth segment in 35 patients (20.83%), while the less affected segment was the second liver segment in 8 patients (4.73%). most of patients (62 patients or 36.90%) had more than two affected segments in time of diagnosis. Diagnostic criteria in this study require further future evaluation. Conclusion: Early diagnosis of are tumors remains a real challenge and has great impact in the survival rate of patients. Finally, our study showed that for our country's institutions that there was no significant difference between both CT and MRI modalities in liver focal lesions assessment.

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“…Bile acids induce DNA damage through the induction of reactive oxygen species (18). Therefore, adenocarcinoma in the duodenum seen after cholecystectomy has been attributed to proximity to the common bile duct (19). The most common location of small bowel adenocarcinomas is in the ampullary region of the duodenum (D2) (20).…”

Section: Discussionmentioning

confidence: 99%

A potential association between exposure to hepatitis B virus and small bowel adenocarcinoma

DeFilippis

Mehta

Ludwig

2016

J. Gastrointest. Oncol.

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Chronic infection with hepatitis B virus (HBV) has never been described as a risk factor for small bowel adenocarcinoma, although infection is a known risk factor for hepatocellular carcinoma. From May 2009 to December 2014, we implemented an institution-wide screening program for hepatitis B viral serologies prior to starting chemotherapy. Evidence of exposure [hepatitis B core antibody (anti-HBc) positivity in the absence of hepatitis B surface antigen (HBsAg) positivity] was highest in patients with hepatocellular carcinoma (21.1%), followed by small bowel cancer (12.5%). The small bowel adenocarcinoma cases with anti-HBc positivity were reviewed. Special attention was paid to known risk factors for small bowel cancers. One patient had a diagnosis of hereditary nonpolyposis colorectal cancer (HNPCC). However, the other patients had no genetic syndromes, history of inflammatory bowel disease or other chronic inflammation to explain their risk. We postulate exposure to bile acids, tumorigenesis of hepatocytes and cholangiocytes, and/or damage to the intestinal mucosa secondary to HBV exposure/infection as potential mechanisms for development of small bowel adenocarcinoma. More research is warranted to further elucidate this association.

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Cholecystectomy and the risk of alimentary tract cancers: A systematic review

Abstract: This is a comprehensive review of the association between GIT cancers and cholecystectomy. This review found no clear association between cholecystectomy and GIT cancers.

Cited by 30 publications

References 103 publications

Cholecystectomy and the risk of colorectal cancer by tumor mismatch repair deficiency status

Cholecystectomy and the risk of colorectal cancer by tumor mismatch repair deficiency status

MRI and CT into Pathology Tumor and Liver Bile Duct

A potential association between exposure to hepatitis B virus and small bowel adenocarcinoma

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