Cholecystectomy Damages Aging-Associated Intestinal Microbiota Construction

Wang, Wenxue; Wang, Junfeng; Li, Julan; Yan, Peng; Yun, Jimmy; Zhang, Ruyi; Yue, Wei; Guo, Qiang; Geng, Jiawei

doi:10.3389/fmicb.2018.01402

Cited by 61 publications

(59 citation statements)

References 66 publications

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“…There is currently an increasing number of studies about the role of the gut microbiome as a key link in the pathogenesis of GSD [ 10 , 11 , 12 , 13 , 14 , 15 , 16 ]. The main factors contributing to the formation of gallstones are defective gallbladder motility, metabolism and secretion of cholesterol and bile acids [ 12 ]; the gut microbiota is actively involved in the regulation of bile acid metabolism, changing the size and composition of the bile acid pool [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Gallstone Disease and Microbiome

Григорьева

Romanova

2020

Microorganisms

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Gallstone disease (GSD) has, for many years, remained a high-cost, socially significant public health problem. Over the past decade, a number of studies have been carried out—both in humans and in animal models—confirming the role of the microbiota in various sections of the gastrointestinal tract as a new link in the etiopathogenesis of GSD. The microbiome of bile correlates with the bacterial composition of saliva, and the microbiome of the biliary tract has a high similarity with the microbiota of the duodenum. Pathogenic microflora of the oral cavity, through mechanisms of immunomodulation, can affect the motility of the gallbladder and the expression of mucin genes (MUC1, Muc3, MUC4), and represent one of the promoters of stone formation in the gallbladder. The presence of H. pylori infection contributes to the formation of gallstones and affects the occurrence of complications of GSD, including acute and chronic cholecystitis, cholangitis, pancreatitis. Intestinal bacteria (Clostridium, Bifidobacterium, Peptostreptococcus, Bacteroides, Eubacterium, and Escherichia coli) participating in the oxidation and epimerization of bile acids can disrupt enterohepatic circulation and lead to the formation of gallstones. At the same time, cholecystectomy due to GSD leads to the further transformation of the composition of the microbiota in various parts of the gastrointestinal tract, increasing the risk of developing stomach cancer and colorectal cancer. Further research is required to determine the possibility of using the evaluation of the composition of the microbiota of the gastrointestinal and biliary tracts as an early diagnostic marker of various gastroenterological diseases.

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Section: Introductionmentioning

confidence: 99%

Gallstone Disease and Microbiome

Григорьева

Romanova

2020

Microorganisms

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“…Although the difference among average AUC values of H 2 in expired air did not reach the statistical significance, this trend suggests a reduced overall fermentation capacity of gut microbiota in patients with gallstone disease (with or without “in situ” gallbladder), as compared to healthy subjects. This hypothesis could be confirmed, at least in part, by previous observations describing relevant qualitative differences in gut microbiota between healthy subjects, gallstone patients and cholecystectomized subjects . Further studies are certainly required in order to better explore this possibility.…”

Section: Discussionmentioning

confidence: 55%

“…This hypothesis could be confirmed, at least in part, by previous observations describing relevant qualitative differences in gut microbiota between healthy subjects, gallstone patients and cholecystectomized subjects. [60][61][62] Further studies are certainly required in order to better explore this possibility.…”

Section: Discussionmentioning

confidence: 99%

Gastrointestinal defects in gallstone and cholecystectomized patients

Ciaula

Molina-Molina

Bonfrate

et al. 2019

Eur J Clin Investigation

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Background and aim Several gallstone patients complain of dyspeptic symptoms, irrespective of the presence of typical colicky pain. Symptoms often persist after a cholecystectomy. Systematic studies on dyspepsia and dynamic gastrointestinal motor function are missing in gallstone patients with preserved gallbladder or after a cholecystectomy. Materials and methods Forty‐six gallstone patients (age 55 ± 2 years; 15M, 31F) and 24 cholecystectomized patients (age 57 ± 2 years; 6M, 18F) (no difference in type and volume of gallstones between the two groups) were compared against a group of 65 healthy controls (age 51 ± 2 years; 30M, 35F). Dyspepsia occurring in the prior months was assessed by a questionnaire, gastric and gallbladder emptying by functional ultrasonography and orocecal transit time by a hydrogen breath test using a lactulose‐enriched standard liquid meal. Results Gallstone patients had significantly greater dyspepsia, fasting and residual gallbladder volumes, and slower gallbladder emptying, gastric emptying and small intestinal transit time than controls. In cholecystectomized patients, gastric emptying further delayed, compared to gallstone patients and controls. Conclusion Gallstone patients with the gallbladder “in situ” or after a cholecystectomy display dyspeptic symptoms. Symptoms are associated with multiple gastrointestinal motility defects involving the gallbladder, stomach and small intestine. After cholecystectomy, gastric emptying worsens.

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“…Парфенов рассмотрел хологенную диарею как вариант секреторной формы [5,6]. В исследовании W. Wang и соавт., результаты которого были опубликованы в 2018 г., изучалась связь между изменением состава кишечной микробиоты после холецистэктомии и развитием колоректального рака [7]. Авторы предположили, что усиление бактериальной деконъюгации и дегидроксилирования ЖК приводит к увеличению доли вторичных ЖК, образующихся в толстой кишке под влиянием кишечной микрофлоры.…”

Section: гастроэнтерологияunclassified