Cholecystic adenocarcinoma and pancreatic insulinomas in a goat

Abstract

Abstract.A 13-year-old female Boer goat with a history of chronic arthritis and recurrent episodes of recumbency, increased serum gamma-glutamyl transferase, and complete inability to stand was submitted for necropsy. Gross changes included the presence of a white, firm, smooth, 6 cm × 4 cm × 3 cm mass that diffusely expanded and partially effaced the gall bladder and infiltrated the adjacent hepatic parenchyma. On cut surface, the mass was pale yellow and had small, irregular, dark yellow areas. Scattered through the pancreas were 2 gray, well-demarcated, soft, homogeneous, 1 cm in diameter nodules that bulged out from the capsular surface. The right femoral head had a locally extensive area of cartilage erosion. Histological and immunohistochemical evaluation of the gall bladder and pancreatic nodules revealed a primary cholecystic adenocarcinoma and multifocal insulinomas, respectively. A metastatic focus from the gall bladder neoplasm was observed infiltrating the right adrenal gland medulla. The goat also had mild pulmonary infestation by Muellerius capillaris. Primary hepatobiliary and pancreatic neoplasia is rare in goats, and to the authors' knowledge, neither cholecystic adenocarcinoma nor pancreatic insulinomas have been previously reported in this species.

Goats diagnosed with neoplasia display variability in clinical presentations, treatments, and outcomes

“…Four of the 13 (31%) goats diagnosed with skin SCC were Saanens, though Saanens were not overrepresented in this group (P = .20). Other breeds included Cashmere (n = 3), mixed breed (2), Nubian (1), Nigerian Dwarf (1), Boer (1), and Tennessee Fainting (1). The majority of goats with SCC (12/14 [86%]) had a white hair coat.…”

“…However, unlike in small-animal or equine medicine in which neoplastic diseases are better understood, there are limited published data on clinical presentation, treatment, or outcome in goats with neoplasia.Specific caprine neoplasms have been described in case reports and a limited number of retrospective analyses. [1][2][3][4][5][6] Yau and Rissi 7 reported a case of a goat with cholecystic adenocarcinoma and insulinomas, and 2 cases of leiomyosarcoma in related Saanen does have been described. Hill et al 6 reported the clinical signs, signalment, treat-…”

“…Specific caprine neoplasms have been described in case reports and a limited number of retrospective analyses. [1][2][3][4][5][6] Yau and Rissi 7 reported a case of a goat with cholecystic adenocarcinoma and insulinomas, and 2 cases of leiomyosarcoma in related Saanen does have been described. Hill et al 6 reported the clinical signs, signalment, treat-…”

Multiple endocrine neoplasia in a sheep: insulinoma, adrenocortical carcinoma with myxoid differentiation, and thyroid C-cell carcinoma

“…Insulinoma has been reported in various animal species including dogs, cats, ferrets, horses, cows, and a goat. 7,8,25 We found no reports of insulinoma in sheep in a search of Google, PubMed, and Scopus. Insulinomas are classified as benign or malignant depending on the behavior of the tumor.…”

“…7 Although the incidence of insulinoma in ruminants is rarer than in companion animals, insulinoma has been described in slaughtered adult cows 8 and an aged goat. 25 We retrieved no ovine cases of MEN or insulinoma in a search of Google, PubMed, and Scopus, suggesting that those conditions have not been reported in sheep.…”