Cholecystokinin Induces Fos Expression in the Brain of the Japanese Quail

Boswell, Tim; Li, Q.

doi:10.1006/hbeh.1998.1465

Cited by 2 publications

(1 citation statement)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CCK also exerts actions over oxytocinergic neurons of the paraventricular nucleus (Cano et al 2003). In birds, intraventricular CCK application inhibits feeding and also exerts effects (activation of Fos-like immunoreactivity) on nuclei of the hypothalamus (Boswell and Li 1998). In the preoptic region and the hypothalamus of teleosts, the presence of CCK-ir perikarya was reported in the entopeduncular nucleus, preoptic nucleus, anterior or posterior periventricular nucleus, lateral recess nucleus and lateral tuberal nucleus (Poecilia: Batten et al 1990;goldfish: Himick and Peter 1994).…”

Section: Preoptic Region and Hypothalamusmentioning

confidence: 99%

Cholecystokinin in the central nervous system of the sea lamprey Petromyzon marinus: precursor identification and neuroanatomical relationships with other neuronal signalling systems

et al. 2019

View full text Add to dashboard Cite

Cholecystokinin (CCK) is a neuropeptide that modulates processes such as digestion, satiety and anxiety. CCK-type peptides have been characterized in jawed vertebrates and invertebrates, but little is known about CCK-type signalling in the most ancient group of vertebrates, the agnathans. Here we have cloned and sequenced a cDNA encoding a sea lamprey (Petromyzon marinus L.) CCK-type precursor (PmCCK), which contains a CCK-type octapeptide sequence (PmCCK-8) that is highly similar to gnathostome CCKs. Using mRNA in situ hybridization, the distribution of PmCCK-expressing neurons was mapped in the CNS of P. marinus. This revealed PmCCK-expressing neurons in the hypothalamus, posterior tubercle, prethalamus, nucleus of the medial longitudinal fasciculus, midbrain tegmentum, isthmus, rhombencephalic reticular formation and the putative nucleus of the solitary tract. Some PmCCK-expressing neuronal populations were only observed in adults, revealing 3 important differences with larvae. We generated an antiserum to PmCCK-8 to enable immunohistochemical analysis of CCK expression, which revealed that GABA or glutamate, but not serotonin, tyrosine hydroxylase or neuropeptide Y, are co-expressed in some PmCCK-8-immunoreactive (ir) neurons. Importantly, this is the first demonstration of co-localization of GABA and CCK in neurons of a non-mammalian vertebrate. We also characterized extensive cholecystokinergic fibre systems of the CNS, including innervation of habenular subnuclei. A conspicuous PmCCK-8-ir tract ascending in the lateral rhombencephalon selectively innervates a glutamatergic population in the dorsal isthmic grey. Interestingly, this tract is reminiscent of the secondary gustatory/visceral tract of teleosts. In conclusion, this study provides important new information on the evolution of the cholecystokinergic system in vertebrates.

show abstract

Section: Preoptic Region and Hypothalamusmentioning

confidence: 99%