1999
DOI: 10.3892/ijo.14.6.1129
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Cholecystokinin regulates the invasiveness of human pancreatic cancer cell lines via protein kinase C pathway.

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Cited by 11 publications
(5 citation statements)
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“…CCK-A receptors were detected using reverse transcription followed by the polymerase chain reaction (RT-PCR) selectively in human pancreatic adenocarcinomas (22)(23)(24)(25). CCK has a trophic effect on xenografted human pancreatic cancer, with increase of tumour weight, protein and DNA content (26,27), and regulates the invasiveness of human pancreatic cancer cell lines (28). CCK-induced proliferation of human pancreatic cancer cells was inhibited by the CCK-A receptor antagonists proglumide (10) and loxiglumide (CR-1505) (29) in vitro.…”
Section: Discussionmentioning
confidence: 99%
“…CCK-A receptors were detected using reverse transcription followed by the polymerase chain reaction (RT-PCR) selectively in human pancreatic adenocarcinomas (22)(23)(24)(25). CCK has a trophic effect on xenografted human pancreatic cancer, with increase of tumour weight, protein and DNA content (26,27), and regulates the invasiveness of human pancreatic cancer cell lines (28). CCK-induced proliferation of human pancreatic cancer cells was inhibited by the CCK-A receptor antagonists proglumide (10) and loxiglumide (CR-1505) (29) in vitro.…”
Section: Discussionmentioning
confidence: 99%
“…The invasiveness and the production of MMP-9 were decreased with staurosporine but not indomethacine. These results suggest that CCK may regulate the invasiveness and the production of MMP-9 via protein kinase C in human pancreatic cancer cell lines [15]. Cholecystokinin (CCK) receptors play a role in the development and growth of pancreatic cancers.…”
Section: Cholecystokinin and Cancermentioning
confidence: 92%
“…According to their expression in normal tissues, the CCK-B receptor is expressed in adenocarcinomas of all areas of the gastrointestinal tract, whereas the CCK-A receptor is rarely expressed in gastroenteropancreatic tumors [139][140][141]. CCK and gastrin promote the invasiveness of human pancreatic cancer cell lines [142], and of human colon cancer cells [143], respectively.…”
Section: Positive and Negative Regulation Of Tumor Cell Migrationmentioning
confidence: 99%