2019
DOI: 10.1155/2019/4748194
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Choledochotomy for Obstructive Choledocholithiasis in Two Dogs

Abstract: Two geriatric (> 9 years old) dogs presented for vomiting, lethargy, and anorexia. Obstructive choledocholithiasis was diagnosed based on analysis of a serum biochemical analysis and abdominal radiographs and ultrasonography. In both dogs, choledocholiths were removed from the common bile duct via a choledochotomy without a cholecystectomy, and survival without recurrence occurred in both dogs for more than 1 year.

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Cited by 5 publications
(7 citation statements)
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“…Hyperlipidemia refers to increased lipid concentrations in the blood, including total cholesterol and triglycerides 26 . Our findings were consistent with Lee et al (2017) 2 and Folk and Lux (2019), 28 where it was demonstrated that serum TC and TG concentrations were significantly elevated in dogs with cholecystolithiasis compared with controls matched by body weight. Hyperlipidemia was identified as a major risk factor for enhancing gallbladder stasis and cholelithogenesis.…”
Section: Discussionsupporting
confidence: 91%
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“…Hyperlipidemia refers to increased lipid concentrations in the blood, including total cholesterol and triglycerides 26 . Our findings were consistent with Lee et al (2017) 2 and Folk and Lux (2019), 28 where it was demonstrated that serum TC and TG concentrations were significantly elevated in dogs with cholecystolithiasis compared with controls matched by body weight. Hyperlipidemia was identified as a major risk factor for enhancing gallbladder stasis and cholelithogenesis.…”
Section: Discussionsupporting
confidence: 91%
“…Notably, serum activities of hepatic (ALT and AST) and biliary (ALP and GGT) enzymes were statistically increased indicating the presence of hepatic and biliary injury in both cholecystolithiasis groups compared with the control group; however, although the ALT and AST trended toward significance, these variables were not clinically significant, as their levels in both cholecystolithiasis groups did not exceed the upper limit of in‐clinic standard reference intervals. This statistical increase could be the result of enzyme leakage into serum due to disturbed hepatic cholesterol homeostasis that might contribute not only to hepatocyte cholesterol accumulation and steatohepatitis but also to cholecystolithiasis and inflammation or structural changes within the biliary epithelium 28 . On histopathology, lipid vacuoles were observed in hepatocytes in the C+HS group.…”
Section: Discussionmentioning
confidence: 97%
“…There is even less information regarding survival in dogs that require choledochotomy, cholecystoenterostomy or primary repair of the CBD. More recent case series suggest that outcome following these procedures may not be as grim as previously thought (Baker et al 2011, Folk & Lux 2019, Ward et al 2020.…”
Section: Cholecystolithiasis and Extrahepatic Cholelithiasismentioning
confidence: 93%
“…Investigators in one study reported that 87% (53/61) of dogs were subclinical at the time of cholelith identification (Ward et al 2020). The presence and severity of clinical signs are typically related to complications that can manifest as a result of cholelithiasis, which in dogs, includes partial or complete EHBDO, gall bladder rupture, sterile or septic bile peritonitis, all subtypes of cholecystitis (see above; cholecystitis section), emphysematous cholecystitis, cholangitis/cholangiohepatitis and cholecystocutaneous fistula (Wales et al 1982, Church & Matthiesen 1988, Bromel et al 1998a, Mehler et al 2004, Baker et al 2011, Fabbi et al 2014, Lawrence et al 2015, Tamborini et al 2016, Folk & Lux 2019, Ward et al 2020. In humans, less severe clinical signs of cholelithiasis could include episodic abdominal pain known as "biliary colic".…”
Section: Cholecystolithiasis and Extrahepatic Cholelithiasismentioning
confidence: 99%
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