Choleretic effects of yarrow (Achillea millefolium s.l.) in the isolated perfused rat liver

Benedek, Birgit; Geisz, Nora; Jäger, Walter; Thalhammer, Theresia; Kopp, Brigitte

doi:10.1016/j.phymed.2005.10.005

Cited by 70 publications

(48 citation statements)

References 5 publications

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“…Encapsulation of essential oils or their chemical components with β-cyclodextrin or derivatives for improvement of biological properties have been observed (Astray, González-Barreiro, Mejuto, Rial-Otero & Simal-Gándara, 2009;Benedek, Geisz, Jager, Thalhammer, & Kopp, 2006;Chandler, Hooper, & Harvey, 1982;Keser, Celik, Turkoglu, Yilmaz, & Turkoglu, 2011. Encapsulation of essential oils from cinnamon and clove could improve their antimicrobial activity has been reported (Hill, Gomes, & Taylor, 2013).…”

Section: Introductionmentioning

confidence: 99%

Encapsulation of yarrow essential oil in hydroxypropyl-beta-cyclodextrin: physiochemical characterization and evaluation of bio-efficacies

Rakmai

Cheirsilp

Agrasar

et al. 2017

CyTA - Journal of Food

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Essential oil from yarrow (Achillea millefolium L. s. l.) has a broad spectrum of pharmacological activities. However, active chemical components of yarrow oil are sensitive to environmental factors such as, light, oxygen and temperature. Encapsulation of essential oil offers solutions for the limitation. Yarrow oil was encapsulated in hydroxypropyl-β-cyclodextrin (HPβCD) through freezedrying technique with encapsulation efficiency of 45%. Inclusion complex formation was examined by scanning electron microscope, Fourier transformed infrared spectroscopy and UV-vis analysis and phase solubility study. Yarrow oil gave strong antioxidant activity of 72% DPPH scavenging at 50 μg/mL. HPβCD could protect active compounds of essential oil and retained antioxidant activity after sunlight exposure. Yarrow oil also exhibited antibacterial activity against Staphylococcus aureus and Escherichia coli with the minimum inhibitory concentration (MIC) values of 250 μg/mL and 500 μg/mL, respectively. The antibacterial efficacy was much improved after encapsulation against both S. aureus and E. coli with the MIC value of 62.5 μg/mL.Encapsulación de aceite esencial de milenrama en hidroxipropil-beta-ciclodextrina. Caracterización fisicoquímica y evaluación de bioeficiencia. RESUMENEl aceite esencial de la milenrama (Achillea millefolium L. s. l.) presenta un amplio espectro de actividades farmacológicas. Sin embargo, los componentes químicos activos del aceite son sensibles a factores ambientales tales como, luz, oxígeno y temperatura. La encapsulación del aceite esencial ofrece soluciones para esta limitación. El aceite se encapsuló en hidroxipropil-β-ciclodextrina (HPβCD) mediante la técnica de liofilización con un rendimiento del 45%. La formación del complejo de inclusión se analizó mediante técnicas de SEM, FT-IR y UV-vis y se realizó un estudio de solubilidad. El aceite presentó una fuerte actividad antioxidante de 72% de DPPH. HPβCD protege los compuestos activos de aceite esencial y retoene la actividad antioxidante después de la exposición a luz solar. El aceite también exhibió actividad antibacteriana contra Staphylococcus aureus y Escherichia coli con valores mínimos de concentración inhibitoria (MIC) de 250 μg/mL y 500 μg/mL, respectivamente. La eficacia antibacteriana mejoró mucho después de la encapsulación contra S. aureus y E. coli con un valor de CIM de 62,5 μg /ml. ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

Encapsulation of yarrow essential oil in hydroxypropyl-beta-cyclodextrin: physiochemical characterization and evaluation of bio-efficacies

Rakmai

Cheirsilp

Agrasar

et al. 2017

CyTA - Journal of Food

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“…Furthermore, a study of the methanol extract from Achillea ageratum L. in several experimental models showed the analgesic and antipyretic properties, whereas phytochemical investigation of the extract revealed the presence of flavonic compounds, thus suggesting that flavonoids might induce the respective effects (9). Recent attention has been directed towards the dicaffeoylquinic acids present in yarrow, since these phenolic acids were shown to cause the choleretic effects (10). Two flavonoids casticin (11) and centaureidin (12), respectively, derived from A. millefolium and A. clavennae L., were Medicina (Kaunas) 2008; 44 (10) EKSPERIMENTINIAI TYRIMAI observed to exert cytotoxic activity.…”

Section: Introductionmentioning

confidence: 99%

“…Recent attention has been directed towards the dicaffeoylquinic acids present in yarrow, since these phenolic acids were shown to cause the choleretic effects (10). Two flavonoids casticin (11) and centaureidin (12), respectively, derived from A. millefolium and A. clavennae L., were Medicina (Kaunas) 2008; 44 (10) EKSPERIMENTINIAI TYRIMAI observed to exert cytotoxic activity. The results from in vitro assay, based on recombinant MCF-7 cells, indicated that flavonoids from A. millefolium exhibit estrogenic activity (13).…”

Section: Introductionmentioning

confidence: 99%

Variability of phenolic compounds in flowers of Achillea millefolium wild populations in Lithuania

Benetis¹,

Radušienė²,

Janulis³

2008

Medicina

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“…Une description sommaire des plantes est présentée ici suivi d'une photo de chacune de ces plantes (voir figure 5) (Marie-Victorin, 1995 (Candan et al, 2003;Kintzios et al), anti-inflammatoire (Benedek and Kopp, 2007;Goldberg et al, 1969), antinociceptive (Pires et al, 2009) et antifertilité (Takzare et al, 2010). De plus, plusieurs groupes de recherche ont rapporté qu'Achillea millefolium possède des propriétés : protectrice contre les lésions gastriques chroniques (Cavalcanti et al, 2006) 5 antiulcérogène (Potrich et al, 2010), hépatoprotectrice (Yaeesh et al, 2006), cholérétique (Benedek et al, 2006) et antidiarrhéique (Babaei et al, 2007). Finalement, Achillea millefolium a aussi montré une activité cytotoxique in vitro contre les cellules cancéreuses humaines du foie HA22T/VGH , les cellules cancéreuses du col de l'utérus HeLa et les cellules cancéreuses du sein MCF-7 (Csupor-Loffler et al,…”

Section: Description Des Plantesunclassified

Évaluation de l'activité antivirale de cinq espèces végétales de la forêt boréale contre les virus influenza de type A et l'herpès simplex de type 1 /

Côté¹

2011

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RÉSUMÉL'action directe des extraits sur les virus a également été testée. Finalement, la cytotoxicité des extraits a été déterminée sur des fibroblastes de peau humaine en culture. IllLes résultats ont montré que la plupart des extraits possédaient une activité modérée contre Y influenza. La plante ayant obtenue la meilleure activité est Cornus canadensis avec une inhibition de 16 à 96% (selon le moment de l'infection) à une concentration de 100|Lig/ml. D'autre part, cette plante a également été trouvée fortement active contre le virus de l'herpès simplex de type 1. Les extraits de feuilles ont non seulement une activité antivirale directe sur le virus (IC50 =11 |ig/ml) mais inhibent aussi sa replication (IC50 = 44 |ug/ml). L'ensemble des résultats obtenus in vitro confirme l'activité antivirale contre le virus de 1'influenza de plusieurs plantes utilisées en médecine traditionnelle amérindienne et montre pour la première fois une activité contre le virus de l'herpès simplex type 1. Park and Fowler, 1989;Turner and Efrat, 1982) Décoction : toux, rhume et fièvre 18 Traitements et résistances Description des plantesLes cinq plantes sélectionnées pour ce projet sont présentes dans la forêt boréale québécoise. Une description sommaire des plantes est présentée ici suivi d'une photo de chacune de ces plantes (voir figure 5) (Marie-Victorin, 1995). UAchillea millefolium, ou For inhibition of HSV-1 replication, G canadensis extracts exhibited also the higher activity with IC50 values ranging from 44 to 69 |ig/ml. Finally, water/ethanol decoction of A. millefolium leaf was found the most active extract to inhibit directly HSV-1 with an IC50 29 value of 4.8 ± 0.6 |ig/ml. Altogether, the results presented in this work support antiviral activity of some plants used in Native American traditional medicine. 30

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Choleretic effects of yarrow (Achillea millefolium s.l.) in the isolated perfused rat liver

Cited by 70 publications

References 5 publications

Encapsulation of yarrow essential oil in hydroxypropyl-beta-cyclodextrin: physiochemical characterization and evaluation of bio-efficacies

Encapsulation of yarrow essential oil in hydroxypropyl-beta-cyclodextrin: physiochemical characterization and evaluation of bio-efficacies

Variability of phenolic compounds in flowers of Achillea millefolium wild populations in Lithuania

Évaluation de l'activité antivirale de cinq espèces végétales de la forêt boréale contre les virus influenza de type A et l'herpès simplex de type 1 /

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