Cholestane and spirostane-type glycosides from the roots and rhizomes of Panicum repens L.

Temraz, Abeer; Hozaien, Hoda E.; El-Tantawy, Walid Hamdy; El-Gindi, Omayma D.; Taha, Kamilia F.

doi:10.1016/j.phytol.2014.09.005

Cited by 4 publications

(3 citation statements)

References 7 publications

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“…Moreover, luteolin and its derivative, luteolin-4 ′ -O-glucoside, exhibited strong efficacy in treating hyperuricemia and gout in the clinic [23], and showed antioxidative potential in RAW 264.7 cells [24]. Studies on plants of the genus Panicum found that P. turgidum and P. repens contain the steroid, saponin, as well as phenolic compounds such as rutin, caffeic acid, and protocatechuic acid [25][26][27][28]. Bioactivity studies showed that P. miliare has antihyperlipidemic efficacy and that P. maximum has antidiabetic and anti-inflammatory effects [29][30][31].…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Panicum dichotomiflorum in a Rodent Model of Testosterone-Induced Benign Prostatic Hyperplasia

Baek,

Hong,

Kim

et al. 2024

Sci. Pharm.

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Benign prostatic hyperplasia (BPH) is a common disease in aging men. Panicum dichotomiflorum (PD) is an annual grass species of Poaceae that is distributed worldwide. The present study examined whether PD has a protective effect against BPH. BPH was generated in rats by daily subcutaneous administration of testosterone for four weeks. During this period, the rats were also given daily oral gavages of an extract of PD (150 mg/kg). After the final treatment, all animals were euthanized and their prostates were collected and weighed. In BPH model rats, the prostate weight and levels of dihydrotestosterone (DHT) and 5α-reductase expression were inhibited following treatment with PD extract. Testosterone-induced increases in prostate gland epithelial thickness and expression of cyclin D1 and proliferating cell nuclear antigen (PCNA) were markedly suppressed in PD-treated rats, whereas cleaved caspase-3 levels were increased. PD administration also decreased the expression of transforming growth factor (TGF)-β and vascular endothelial growth factor (VEGF), the phosphorylation of Akt, and inflammatory cytokines levels. Taken together, these results show that PD extract protects against testosterone-induced BPH progression by alleviating prostate cell growth and reducing levels of growth factors and inflammatory cytokines, indicating that PD extract may have potential in protecting against BPH.

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Section: Introductionmentioning

confidence: 99%

Protective Effect of Panicum dichotomiflorum in a Rodent Model of Testosterone-Induced Benign Prostatic Hyperplasia

Baek,

Hong,

Kim

et al. 2024

Sci. Pharm.

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“…The genus Panicum (Poaceae) encompasses above 600 species [1]. Panicum turgidum Forssk., a perennial desert grass, forming rounded bushes, has been grown in Egypt for many centuries.…”

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confidence: 99%

“…It was reported that Bedouins used P. turgidum as food during famine, as well as for wound dressing [2a]. Literature revealed that some Panicum species have anti-inflammatory, antipyretic [2b], antileishmanial [2c], antidiabetic [2d], antifungal [2e], aphrodisiac, hypolipidemic and diuretic activities [1]. These biological activities were mainly attributed to steroidal saponins, which are typical constituents of the genus.…”

mentioning

confidence: 99%