Cholestasis in Ulcerative Colitis

Cello, John P.; Baumgartel, Earl D.; Filly, Roy A.; Goldberg, Henry I.; Margulis, Alexander R.; Ockner, Robert K.; Schmid, Rudi; Shapiro, Howard; Sleisenger, Marvin H.; Smuckler, Edward A.; Way, Lawrence W.

doi:10.1016/s0016-5085(19)32226-7

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Cited by 21 publications

(2 citation statements)

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“…Eligible patients were men and women, aged between 18 and 75 years, who had a confirmed diagnosis of intermittent chronic ulcerative colitis 10 in stable clinical, endoscopic and histological remission for at least 1 year. Remission was defined as an absence of active disease symptoms and no signs of active inflammation on sigmoidoscopy.…”

Section: Methodsmentioning

confidence: 99%

Is maintenance therapy always necessary for patients with ulcerative colitis in remission?

Ardizzone

Petrillo

Imbesi

et al. 1999

Aliment Pharmacol Ther

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Section: Methodsmentioning

confidence: 99%

Is maintenance therapy always necessary for patients with ulcerative colitis in remission?

Ardizzone

Petrillo

Imbesi

et al. 1999

Aliment Pharmacol Ther

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“…Another of our reported patients has a brother and a dog with ulcerative colitis and sclerosing cholangitis (3). A patient in the literature has repeatedly responded to cholestyramine therapeutic trials (16); however, previous studies have not supported monohydroxy bile acids as the etiologic factor (17). Interestingly, 23% of patients have pathologic evidence on liver biopsy of portal phlebitis or phlebosclerosis (10).…”

Section: Editorialsmentioning

confidence: 88%

What Is “Primary Sclerosing Cholangitis”?

Sharp,

Freese

1987

J. pediatr. gastroenterol. nutr.

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Pruritus in Hepatic Cholestasis

Garden¹

1985

Arch Dermatol

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Pruritus associated with hepatic cholestasis may cause significant morbidity. Current evidence indicates that bile acids may not be the pruritogenic factor. Rather, the factor may be some other cholephilic anion or anions that bind to cholestyramine resin and are photolabile. Effective treatment modalities used currently include cholestyramine resin and phenobarbital. Phototherapy is a promising modality in which the mechanism and most effective wavelengths remain to be elucidated. Analysis of the possible role of non-steady state bile acid compartmentalization in the pathogenesis of pruritus is presented.

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Cholestasis in Ulcerative Colitis

Cited by 21 publications

References 48 publications

Is maintenance therapy always necessary for patients with ulcerative colitis in remission?

Is maintenance therapy always necessary for patients with ulcerative colitis in remission?

What Is “Primary Sclerosing Cholangitis”?

Pruritus in Hepatic Cholestasis

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