Cholestatic jaundice after hepatic transplantation

Williams, James W.; Vera, Santiago; Peters, Thomas G.; Voorst, Steven Van; Britt, L. G.; Dean, Philip A. W.; Haggitt, Roger C.; Massie, James D.

doi:10.1016/0002-9610(86)90013-9

Cited by 77 publications

(20 citation statements)

References 2 publications

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“…However, high doses of vasoconstrictors may lead to severe ischemic complications. In the postliver transplant patient, poor graft perfusion from hypotension has been linked to graft dysfunction, postoperative renal failure, and death [21,22]. Thus, the use of alternative medications for the treatment of hypotension in liver transplantation is of interest.…”

Section: Discussionmentioning

confidence: 99%

The response to methylene blue in patients with severe hypotension during liver transplantation

Berman

Merritt

Hendrickse

et al. 2012

Journal of Clinical Anesthesia

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Section: Discussionmentioning

confidence: 99%

The response to methylene blue in patients with severe hypotension during liver transplantation

Berman

Merritt

Hendrickse

et al. 2012

Journal of Clinical Anesthesia

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“…The European grading system for acute liver allograft reMost investigators have observed similar histopathological findings associated with acute rejection. [10][11][12][13][14][15][16][17][18][19][20][21][22] Core needle bi-jection, developed by Hubscher and Dousset et al at Birmingham 27-29 , is based on a semiquantitative analysis of the opsy specimens may show the following: 1) mixed but predominantly mononuclear portal inflammation, containing diagnostic triad of Snover et al 18 In this system, portal inflammation, bile duct damage, and venous endothelial inblastic (activated) lymphocytes, neutrophils, and frequently eosinophils; 2) bile duct inflammation/damage; and 3) suben-flammation are each graded semiquantitatively on a scale of 0 (absent) to 3 (severe). The individual scores are then added dothelial inflammation of portal veins or terminal hepatic venules.…”

Section: Histopathologic Findingsmentioning

confidence: 99%

Banff Schema for Grading Liver Allograft Rejection: An International Consensus Document

et al. 1997

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an internationally acceptable grading system, which has al-A panel of recognized experts in liver transplantation ready been developed for kidney, 3 heart, 4 and lung. 5 At the pathology, hepatology, and surgery was convened for Third Banff Conference on Allograft Pathology, a group of the purpose of developing a consensus document for the specialists in liver transplantation from North America, Eugrading of acute liver allograft rejection that is scientifirope, and Asia met for this purpose. cally correct, simple, and reproducible and clinically useful. Over a period of 6 months pertinent issues were DEFINITION OF ACUTE REJECTION discussed via electronic communication media and a consensus conference was held in Banff, Canada in the In general, organ allograft rejection can be defined as, ''an summer of 1995. Based on previously published data and immunological reaction to the presence of a foreign tissue or the combined experience of the group, the panel agreed organ, which has the potential to result in graft dysfunction on a common nomenclature and a set of histopathologi-and failure.'' 2 This report is specifically concerned with acute cal criteria for the grading of acute liver allograft rejec-rejection, recently defined by the international consensus tion, and a preferred method of reporting. Adoption of document on terminology for hepatic allograft rejection 2 as, this internationally accepted, common grading system ''inflammation of the allograft, elicited by a genetic disparity by scientific journals will minimize the problems associ-between the donor and recipient, primarily affecting interlobated with the use of multiple different local systems. ular bile ducts and vascular endothelia, including portal Modifications of this working document to incorporate veins and hepatic venules and occasionally the hepatic artery chronic rejection are expected in the future. (HEPATOL-and its branches.'' 2 Early rejection, cellular rejection, nonduc-OGY 1997;25:658-663.) topenic rejection, rejection without duct loss, and reversible rejection are synonyms for acute rejection that appear in the literature, but their use is discouraged. The general clinical, The success of hepatic transplantation has resulted in its laboratory, and histopathological abnormalities listed below widespread use for treatment of many patients with endstage were derived from the international consensus document.2 liver disease; it is currently offered by more than 100 centers worldwide. One-year survival rates range from 70% to 90%; CLINICAL AND LABORATORY FINDINGSand long-term survival of 50% to 60% of patients is not unViewed from a biological perspective, any recipient's imcommon.1 Therefore, an increasing number of physicians, inmune system will likely be perturbed after transplantation, cluding pathologists, many of whom have no specific training resulting in immune activation. 2 However, viewed from a in transplantation biology, will become involved in the care clinical perspective, because of baseline immunosuppressive of organ all...

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“…Following liver transplantation, acute arterial thrombosis results in infarctions in hepatobiliary tree and paranchima (6,7). Similarly, portal vein thrombosis following transplantation, is also a serious and lethal complication (8).…”

Section: Discussionmentioning

confidence: 99%

Treatment of Experimental Portal Vein Thrombosis With Streptokinase

Çağa¹,

Gürer²,

Yurtsever³

et al. 1993

Tepecik Dergisi

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In this experimental study. 24 ırats (M us. Norvegius Albinos) were used of which 12 were in the control group, and the other 12 in the therapeutic group. In the control group, porta! vein thrombosis was created. Byvenous statis, and histologkal examinations were performed on the liver spedmens, and liver fundion tests were also acquired for this group. In the the:rapeutic group, low dose streptokinase-3000 units (0.003 cc) was infused through the portal vein at which venous thrınnbosis had beerı. produced experimentaHy. All the :rats were sacdficed on the 7th postoperative day and histological H ver examinations and biochemical studies were pe:rformed. According to the results the:re were no eviden ce of H ver :ischeınia foHowing the use of streptokinase.(Key Words: Uver ischemia, Plasminogene Adivator)ÖZET Bu deneysel çalı~mada, 24 sıçan (Mus. Norvegius Albunos). 12'si kontrol; diğer 12'si ise tedavi grubu olmak üzere iki ayrı gruba ayrıldı. Kontrol grubundaki sıçanlarda, vena porta staz yöntemiyle trombüs olu~turuldu ve trombüs sonrası histolojik karaciğer incelemeleri yapıldı ve karaciğer fonksiyon testlerine bakıldı. Tedavi grubunda ise, aynı yöntemle trombüs olu~turulduktan sonra, intraporfal yoldan düşük doz streptokinaz 3000 ünite (0.003 cc) verildi. Tedavi grubundaki sıçanlar postoperatif 7. günde öldürülerek, postmortem histolojik ve biyokimyasal incelemeler yapıldı. Alınan sonuçlara göre tedavi sonrası karaciğer iskemisine rastlanmadı.

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Cholestatic jaundice after hepatic transplantation

Cited by 77 publications

References 2 publications

The response to methylene blue in patients with severe hypotension during liver transplantation

The response to methylene blue in patients with severe hypotension during liver transplantation

Banff Schema for Grading Liver Allograft Rejection: An International Consensus Document

Treatment of Experimental Portal Vein Thrombosis With Streptokinase

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