Cholesteatoma in cleft lip and palate: A population‐based follow‐up study of children after ventilation tubes

Spilsbury, Katrina; Ha, Jennifer F.; Semmens, James B.; Lannigan, Francis J.

doi:10.1002/lary.23753

Cited by 35 publications

(32 citation statements)

References 25 publications

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“…Recently, Jackler et al [23] criticized the invagination theory in several respects. Their criticism was depending on observing the results of other studies and can be summarized in the following points: first, the occurrence of cholesteatoma was not reduced after cleft palate repair or insertion of ventilation tubes in cleft palate patients [31,32]. Second, observing healthy and well-functioning Eustachian tube in some cholesteatomatous ears.…”

Section: Discussionmentioning

confidence: 99%

Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives

Hamed

Nakata

Sayed

et al. 2016

Clin Exp Otorhinolaryngol

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Cholesteatoma is a cystic non tumorous lesion of the temporal bone that has the ability to destroy nearby structures by its power to cause bone resorption and as a result, fatal complications prevail. We aimed to conduct a comprehensive review for pathogenesis of acquired cholesteatoma, bone resorption mechanisms, and offer a future vision of this serious disease. We have reviewed different theories for pathogenesis of acquired cholesteatoma including the most relevant and updated ones with special emphasis on the mechanisms of bone resorption through Medline/PubMed research using the keywords ‘aetiopathogenesis, bone resorption, acquired cholesteatoma, temporal bone, and cytokines.’ In order to strengthen our study, we searched the reference lists of identified reviews. Cholesteatoma is a subject of debate among otolaryngologists since it was prescribed firstly. Over many decades, several theories were postulated for aetiopathogenesis of cholesteatoma with a tendency to follow more than one theory to explain the proper nature of that disease. Until now, the mechanism of bone resorption has yet to be more clarified. In the last century, a leap has occurred in the field of biomolecular cholesteatoma research which improved our knowledge about its pathophysiology and bone destructive mechanism. However, surgery is still the only available treatment. We conclude that discovery of new therapeutic choices for cholesteatoma other than surgery by the use of anti-growth, anti-proliferative, apoptotic agents as well as medications that antagonize osteoclastogenesis should be the main concern in the future clinical and experimental research work. Also, searching for predictors of the aggressiveness of cholesteatoma can affect the timing of intervention and prevent occurrence of complications.

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Section: Discussionmentioning

confidence: 99%

Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives

Hamed

Nakata

Sayed

et al. 2016

Clin Exp Otorhinolaryngol

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“…Among the various types of complications, tympanosclerosis and otorrhea generally present transient but common sequelae following VTI [73,74], with other studies reported permanent perforations and cholesteatoma [73,75,76]. As for the occlusion of grommets, infection, and the presence of granulation tissue, the evidence was too limited and blurred to determine the direction of effects between VTI and adverse events in CLP children with OME.…”

Section: Vti Versus Non-vtimentioning

confidence: 99%

“…The development of the disease is quite uncommon, with a reported rate of approximately 1% in non-CLP children with VTI [73,87]. However, evidence has shown that the CLP children were at increased risk of developing cholesteatoma [66,73], with a higher rate of 0-6.9% within 12 years after VTI [16,23,58,62,66,67,73,80,88].…”

Section: Cholesteatomamentioning

confidence: 99%

“…It should be noted that Hornigold et al reported an incidence of 29% for CLP children 21 years after VTI for OME [62], Similarly, Spilsbury et al conducted a retrospective cohort study on the relationship between CLP and secondary cholesteatoma following VTI in children [73]. They examined the complete hospital in-patient history of a large unselected population (869 CLP children versus 56080 non-CLP children) over a 29-year period.…”

Section: Cholesteatomamentioning

confidence: 99%

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Tympanostomy Tube Placement for Otitis Media with Effusion in Children with Cleft Lip and Palate

Kuo¹,

Shiao²

2017

Designing Strategies for Cleft Lip and Palate Care

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The condition of cleft lip/palate (CLP) in children is psychologically stressful for family members and debilitating for the patients themselves. These children must undergo a series of major invasive surgeries following birth, including cleft lip repair surgery, cleft palate repair surgery, bone grafting surgery, and dental implant surgery. Unfortunately, the clinical significance of otitis media with effusion (OME), a complication associated with CLP, is often overlooked, and very few studies have explored this condition in depth. This chapter reviews pathogenesis, clinical manifestations, consequences, examination, and diagnosis related to OME in children with CLP. Controversies surrounding the treatment of OME in CLP children are also discussed. We also provide a flowchart for management guidance in OME in children with CLP.

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“…First, other complications apart from resolution and recurrent OME could occur in the middle ear following the removal of the ventilation tube, such as chronic otitis media (COM) with persistent eardrum perforation and cholesteatoma [5][6][7][8]. For example, Phua et al found that the rate of persistent eardrum perforations in children with routine grommet insertion was approximately 9% [5].…”

mentioning

confidence: 97%

Critical reassessment of the probability of receiving additional ventilation tube insertion for recurrent otitis media with effusion in children with cleft palate

Kuo

Tsao

Shiao

2014

Acta Oto-Laryngologica

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Cholesteatoma in cleft lip and palate: A population‐based follow‐up study of children after ventilation tubes

Abstract: Children with cleft conditions are at increased risk of developing cholesteatoma compared to other children who had one or two MEVTIs, although the overall rate of cholesteatoma is declining.

Cited by 35 publications

References 25 publications

Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives

Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives

Tympanostomy Tube Placement for Otitis Media with Effusion in Children with Cleft Lip and Palate

Critical reassessment of the probability of receiving additional ventilation tube insertion for recurrent otitis media with effusion in children with cleft palate

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