2012
DOI: 10.1007/s11010-012-1375-y
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Cholesterogenic genes expression in brain and liver of ganglioside-deficient mice

Abstract: The aim of this study was to determine the effect of changed ganglioside profile on transcription of selected genes involved in cholesterol homeostasis. For that purpose, the expression of 11 genes related to cholesterol synthesis, regulation, and cholesterol transport was investigated in selected brain regions (frontal cortex, hippocampus, brain stem, cerebellum) and liver of St8sia1 knockout (KO) mice characterized by deficient synthesis of b- and c-series gangliosides and accumulation of a-series gangliosid… Show more

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Cited by 4 publications
(5 citation statements)
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“…Furthermore, a disarranged ganglioside environment of Neuroplastin with aging [60] and altered lipid raft functionality during neurodegeneration [61] were reported. In addition, gangliosides are reported to influence cholesterol homeostasis [62], which could be a contributing factor in PMCA regulation [63]. It appears that reshaping the ganglioside milieu of neuronal membranes causes a domino effect, leading to functional changes in ion regulation, and probably other cellular systems as well.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, a disarranged ganglioside environment of Neuroplastin with aging [60] and altered lipid raft functionality during neurodegeneration [61] were reported. In addition, gangliosides are reported to influence cholesterol homeostasis [62], which could be a contributing factor in PMCA regulation [63]. It appears that reshaping the ganglioside milieu of neuronal membranes causes a domino effect, leading to functional changes in ion regulation, and probably other cellular systems as well.…”
Section: Discussionmentioning
confidence: 99%
“…Ganglioside synthesis involves stepwise action of various glycosyl and sialyltransferases [ 30 , 33 , 34 ]. Blockage of ganglioside biosynthetic pathways at a particular step in synthesis results in a change in the ganglioside profile, which can cause deficiency and/or accumulation of certain gangliosides depending on the blocked site in synthesis [ 35 ]. Therefore, changes in ganglioside composition, ganglioside modifications, and the presence or absence of certain ganglioside species can lead to alterations in cellular metabolism.…”
Section: Introductionmentioning
confidence: 99%
“…This deficiency leads to accumulation of a-series gangliosides (GM1, GM2, GM3, GD1a) and a deficiency of b- and c-series gangliosides (GD3, GD1b, GT1b, GT1c, GT2, GT3) [ 36 ]. Loss of certain gangliosides markedly alters ganglioside composition, even though the total concentration of gangliosides in the KO mice remains the same as in wild-type mice (WT) [ 35 ].…”
Section: Introductionmentioning
confidence: 99%
“…There is some evidence that GM3 inhibits apolipoprotein B secretion in liver cells 17 and might regulate hepatic cholesterol metabolism. 18 In light of these observations, the aim of this study was to examine the role of HEXA in hepatic lipid metabolism.…”
Section: Introductionmentioning
confidence: 99%
“…While gangliosides are present in the liver 16 , little is known about the impact of gangliosides or their regulatory proteins in hepatic lipid metabolism in vivo. There is some evidence that GM3 inhibits apolipoprotein B secretion in liver cells 17 and might regulate hepatic cholesterol metabolism 18 . In light of these observations, the aim of this study was to examine the role of HEXA in hepatic lipid metabolism.…”
Section: Introductionmentioning
confidence: 99%