Cholesterol Abnormalities are Common in Women with Prior Gestational Diabetes

Quinlivan, Julie A.; Lam, Danielle

doi:10.4172/2155-6156.1000255

Cited by 8 publications

(6 citation statements)

References 19 publications

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“…Table (2) showed the mean of GDM pregnancy to be (224.50±7.68 mg/dl), while in a healthy pregnancy is (184.80±4.34 mg/dl). The increase of total cholesterol level in the serum of women with GDM in the current study supports the results study of Quinlivan and Lam 26 , and its rise can be attributed to the occurrence of a disorder of fat metabolism ((Dyslipidemia) as a result of the disease 27 . Several studies have shown approaches during the and beyond the pregnancy, adverse metabolic consequences of diabetes 28 .…”

Section: Figure (1): Light Microscopical Appearance Of Normoglycemic Pregnant Women Placenta Showing Microvilli (V) With Narrow Intervillsupporting

confidence: 91%

Histopathological Grading and Enzyme Histochemical Study of the Placenta in Gestational Diabetes Mellitus Pregnant Women

2020

MLU

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Gestational diabetes mellitus (GDM) constitutes carbohydrate metabolism disorders that lead to severe and sometimes life-threatening complications of pregnancy.Materials and Method: 40 placenta biopsies with blood samples were taken from gestational diabetic pregnant women and 20 placenta biopsies with blood samples were taken from healthy pregnant women, the tissues were fixed, processed, embedded and cutting separately depending on procedure for enzyme histochemical and routine histological technique and the blood was centrifuged. Results:The histological changes in the GDM group represented by villous oedema in approximately (30%) of the GDM group, an excessive amount of collagen fibres in the villous stroma (57.5%). Syncytial knots were formed (70 %) in addition to an excessive number of cytotrophoblast cells in about (65 %). The stromal fibrinoid deposition was noticed in (52.5 %). Hypo-vascular villi are seen in (32.5%) also, atherosis of the uteroplacental arteries in (40%) of biopsies. In enzyme histochemistry, the villous stroma of the GDM group has a strong reaction to the G-6-P enzyme. There is a significant increase (p<0.05) in serum blood sugar, cholesterol, blood urea in the GDM group when compared with the normoglycemic group. Conclusions:The increment of serum blood sugar caused histological and enzyme histochemical alteration during pregnancies.

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Section: Figure (1): Light Microscopical Appearance Of Normoglycemic Pregnant Women Placenta Showing Microvilli (V) With Narrow Intervillsupporting

confidence: 91%

Histopathological Grading and Enzyme Histochemical Study of the Placenta in Gestational Diabetes Mellitus Pregnant Women

2020

MLU

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“…Women with prior GDM are known to have a higher prevalence of cardiovascular disease and occurrence of CVD events at a younger age. 19,20 One study shows that there is a link between women GDM or a family history of type 2 diabetes mellitus and their CVD risk. Results from this study showed that women were at a significantly increased risk of developing CVD at a young age.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Triglycerides Levels in Gestational Diabetes - A cross-sectional study

Jahan¹,

Sulaman

Qazi³

et al. 2021

JRMC

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Introduction: Gestational diabetes mellitus (GDM) is the impaired glucose tolerance that is recognized first time during pregnancy. When a woman gets pregnant, glucose intolerance increases and manifests as a positive GDM diagnosis. It has been considered a transient condition because after delivery the majority of cases return to normoglycemic levels. Materials and Methods: This cross-sectional study was conducted in the Department of Obstetrics and Gynecology, Rawal Institute of Health Sciences, Islamabad. Data were collected in a period of 06 months between July 2020 to January 2021. A total of 100 women were included in the study and 5cc of their blood was taken from the vein under aseptic measures for measuring serum triglyceride levels after 12 hours of overnight fasting. Data were analyzed in SPSS version 20.0. Results: The overall mean Serum Triglyceride level of study subjects was 181.17±33.62 mg/dl, with a range of 151-359 mg/dl. Around two-third, 66% of women had <181 mg/dl of Serum Triglyceride level, and 34% of patients had it >181 mg/dl. Our observation was that the mean level of Serum Triglyceride was not different significantly among age, BMI, gestational age, educational and socio-economic groups with p-value >0.05.Conclusion: This study highlights that the circulating mean triglyceride level in GDM subjects was significantly elevated from the normal pregnancy levels.

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“…Centres where the obstetric population has a higher incidence of obesity may report an increase in the incidence in GDM utilising the new diagnostic criteria. However, it is likely that this reflects a genuine increase in metabolic pathology, as obesity is a major risk factor for GDM and adverse pregnancy outcome [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Implementation of the International Association of Diabetes and Pregnancy Study Groups Criteria: Not Always a Cause for Concern

Sibartie¹,

Quinlivan

2015

Journal of Pregnancy

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Background. Controversy surrounds the decision to adopt the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria for the diagnosis of gestational diabetes mellitus (GDM) as fears that disease prevalence rates will soar have been raised. Aims. To investigate the prevalence of pregnancy complicated with GDM before and after the introduction of the IADPSG 2010 diagnostic criteria. Materials and Methods. A prospective audit of all women who delivered from July 1, 2010, to June 30, 2014, in a predefined geographic region within the North Metropolitan Health Service of Western Australia. Women were diagnosed with GDM according to Australian Diabetes in Pregnancy Society (ADIPS 1991) criteria until December 31, 2011, and by the IADPSG 2010 criteria after this date. Incidence of GDM and predefined pregnancy outcomes were audited. Results. Of 10,296 women, antenatal oral glucose tolerance test (OGTT) results and follow-up data were obtained for 10,103 women (98%), of whom 349 (3.5%) were diagnosed with GDM. The rate of GDM utilising ADIPS criteria was 3.4% and the rate of utilising IADPSG criteria was 3.5% (p = 0.92). Conclusion. IADPSG diagnostic criteria did not significantly increase the incidence of GDM in this low prevalence region.

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Cholesterol Abnormalities are Common in Women with Prior Gestational Diabetes

Cited by 8 publications

References 19 publications

Histopathological Grading and Enzyme Histochemical Study of the Placenta in Gestational Diabetes Mellitus Pregnant Women

Histopathological Grading and Enzyme Histochemical Study of the Placenta in Gestational Diabetes Mellitus Pregnant Women

Assessment of Triglycerides Levels in Gestational Diabetes - A cross-sectional study

Implementation of the International Association of Diabetes and Pregnancy Study Groups Criteria: Not Always a Cause for Concern

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