2022
DOI: 10.1101/2022.12.16.520599
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

Cholesterol and ceramide facilitate SARS-CoV-2 Spike protein-mediated membrane fusion

Abstract: SARS-CoV-2 entry into host cells is mediated by the Spike (S) protein of the viral envelope. The S protein is composed of two subunits: S1 that induces binding to the host cell via its interaction with the ACE2 receptor of the cell surface and S2 that triggers fusion between viral and cellular membranes. Fusion by S2 depends on its heptad repeat domains that bring membranes close together, and its fusion peptide (FP) that interacts with and perturb the membrane structure to trigger fusion. Recent studies sugge… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Publication Types

Select...

Relationship

0
0

Authors

Journals

citations
Cited by 0 publications
references
References 52 publications
(79 reference statements)
0
0
0
Order By: Relevance

No citations

Set email alert for when this publication receives citations?