Cholesterol and cognitive performance among community volunteers from the Czech Republic

Chanti‐Ketterl, Marianne; Andel, Ross; Lerch, Ondřej; Laczó, Jan; Hort, Jakub

doi:10.1017/s1041610215000320

Cited by 13 publications

(7 citation statements)

References 36 publications

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“…Although the aforementioned sexual dimorphic associations may help shed light on the current study findings, it is important to recognize inconsistencies in the literature that examine the association between peripheral biomarkers and cognitive function [35]. For example, sexspecific associations between lipids and cognitive function have been mixed, depending on the lipid and the specific cognitive domain under investigation [36,37], warranting a need for future studies to examine dietary patterns and multiple cognitive domains. Moreover, biological mechanisms through which dietary patterns affect cognitive function are likely due to an integrative effect of multiple biological systems and physiological pathways such as inflammatory markers, lipid profile, and vitamin intake [35].…”

Section: Discussionmentioning

confidence: 90%

Sex differences in the relationship between dietary pattern adherence and cognitive function among older adults: findings from the NuAge study

D’Amico

Parrott

Greenwood

et al. 2020

Nutr J

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Background: Consumption of a prudent dietary pattern rich in healthy nutrients is associated with enhanced cognitive performance in older adulthood, while a Western dietary pattern low in healthy nutrients is associated with poor age-related cognitive function. Sex differences exist in dietary intake among older adults; however, there is a paucity of research examining the relationship between sex-specific dietary patterns and cognitive function in later life. Methods: The current study aimed to investigate sex differences in the relationship between sex-specific dietary pattern adherence and global cognitive function at baseline and over a 3-year follow-up in 1268 communitydwelling older adults (M age = 74 years, n = 664 women, n = 612 men) from the Quebec Longitudinal Study on Nutrition and Successful Aging (NuAge). A 78-item Food Frequency Questionnaire was used to estimate dietary intake over the previous year. Sex-specific dietary pattern scores were derived using principal component analysis. Global cognition was assessed using the Modified Mini-Mental State Examination (3MS). Results: Adjusted linear mixed effects models indicated that a healthy, prudent dietary pattern was not associated with baseline cognitive performance in men or women. No relationship was found between Western dietary pattern adherence and baseline cognitive function in women. Among men, adherence to an unhealthy, Western dietary pattern was associated with poorer baseline cognitive function (β = − 0.652, p = 0.02, 95% CI [− 1.22, − 0.65]). No association was found between prudent or Western dietary patterns and cognitive change over time in men or women. Conclusions: These findings highlight the importance of conducting sex-based analyses in aging research and suggest that the relationship between dietary pattern adherence and cognitive function in late life may be sexdependent.

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Section: Discussionmentioning

confidence: 90%

Sex differences in the relationship between dietary pattern adherence and cognitive function among older adults: findings from the NuAge study

D’Amico

Parrott

Greenwood

et al. 2020

Nutr J

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show abstract

“…A study among 130 Australian women with mean age of 62.5 years found a much earlier positive effect of HDL-C (non-fasting) on verbal memory ( 28 ). Another study in the Czech Republic, involving 141 adults (MMSE score≥24, 69 years of age on average, 47% female, 14.4 years of education on average) found an association between HDL-C and better composite cognitive scores (β = 0.30, P = 0.026), only among women ( 29 ). Our study, however, did not find a significant association between HDL-C and cognitive status.…”

Section: Discussionmentioning

confidence: 98%

High Low-Density Lipoprotein Cholesterol Inversely Relates to Dementia in Community-Dwelling Older Adults: The Shanghai Aging Study

et al. 2018

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Background: The relationship between cholesterol and cognitive function is unclear from the previous studies. This study was conducted to explore this association in older Chinese adults.Methods: Data were from the Shanghai Aging Study, comprising 3,836 residents aged 50 years or over in an urban community. Diagnoses of dementia and mild cognitive impairment were established according to the fourth edition of diagnostic and statistical manual of mental disorders (DSM-IV) and Petersen criteria. Multivariate logistic regression models, non-matched and propensity score (PS) matched, were used to examine the association between cholesterol levels and cognitive function.Results: There was a significantly higher proportion of participants with low levels of total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) in the dementia group than in groups without dementia (P < 0.05). High LDL-C level was inversely associated with dementia, with a negative trend in the PS matched model. TC and high density lipoprotein cholesterol (HDL-C) were not significantly related to dementia in either non-matched models or PS matched models.Conclusion: Our result indicates that high level of LDL-C is inversely associated with dementia. High level of LDL-C may be considered as a potential protective factor against cognition decline.

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“…Although the aforementioned sexual dimorphic associations may help shed light on the current study ndings, it is important to recognize inconsistencies in the literature that examine the association between peripheral biomarkers and cognitive function (35). For example, sex-speci c associations between lipids and cognitive function have been mixed, depending on the lipid and the speci c cognitive domain under investigation (36,37), warranting a need for future studies examining dietary patterns and multiple cognitive domains. Moreover, biological mechanisms through which dietary patterns affect cognitive function are likely due to an integrative effect of multiple biological systems and physiological pathways such as in ammatory markers, lipid pro le, and vitamin intake (35).…”

Section: Discussionmentioning

confidence: 99%

Sex differences in the relationship between dietary pattern adherence and cognitive function among older adults: Findings from the NuAge study

D’Amico

Parrott²,

Greenwood

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Consumption of a prudent dietary pattern rich in healthy nutrients is associated with enhanced cognitive performance in older adulthood, while a Western dietary pattern low in healthy nutrients is associated with poor age-related cognitive function. Sex differences exist in dietary intake among older adults; however, there is a paucity of research examining the relationship between sex-specific dietary patterns and cognitive function in later life. Methods: The current study aimed to investigate sex differences in the relationship between sex-specific dietary pattern adherence and global cognitive function at baseline and over a 3-year follow-up in 1268 community-dwelling older adults (Mage=74 years, n = 664 women, n = 612 men) from the Quebec Longitudinal Study on Nutrition and Successful Aging (NuAge). A 78-item Food Frequency Questionnaire was used to estimate dietary intake over the previous year. Sex-specific dietary pattern scores were derived using principal component analysis. Global cognition was assessed using the Modified Mini-Mental State Examination (3MS). Results: Adjusted linear mixed effects models indicated that a healthy, prudent dietary pattern was not associated with baseline cognitive performance in men or women. No relationship was found between Western dietary pattern adherence and baseline cognitive function in women. Among men, adherence to an unhealthy, Western dietary pattern was associated with poorer baseline cognitive function (b = -0.652, p = 0.02, 95% CI [-1.22, -0.65]). No association was found between prudent or Western dietary patterns and cognitive change over time in men or women. Conclusions: These findings highlight the importance of conducting sex-based analyses in aging research and suggest that the relationship between dietary pattern adherence and cognitive function in late life may be sex-dependent.

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Cholesterol and cognitive performance among community volunteers from the Czech Republic

Abstract: HDL-C was the main lipoprotein affecting cognitive function, with results somewhat more pronounced among women. Research should investigate the possibility of finding ways to boost HDL-C levels to potentially promote cognitive function.

Cited by 13 publications

References 36 publications

Sex differences in the relationship between dietary pattern adherence and cognitive function among older adults: findings from the NuAge study

Sex differences in the relationship between dietary pattern adherence and cognitive function among older adults: findings from the NuAge study

High Low-Density Lipoprotein Cholesterol Inversely Relates to Dementia in Community-Dwelling Older Adults: The Shanghai Aging Study

Sex differences in the relationship between dietary pattern adherence and cognitive function among older adults: Findings from the NuAge study

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