Cholesterol and fat in diet disrupt bone and tooth homeostasis in mice

Sato, Yoshihiro; Hosonuma, Masahiro; Sugawara, Daiki; Azetsu, Yuki; Karakawa, Akiko; Chatani, Masahiro; Funatsu, Takahiro; Miki, Takami; Sakai, Nobuhiro

doi:10.1016/j.biopha.2022.113940

Cited by 9 publications

(7 citation statements)

References 28 publications

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“…Furthermore, some evidence is available to corroborate our conclusions from animal research. Studies on animals have revealed that adult rats on a high-fat diet over an extended period of time have elevated levels of both total cholesterol and LDL-C, along with a significant decline in bone density [ 25 ]. Another study using animals revealed that mice lacking APOA1, a crucial molecule that controls the formation of HDL, had considerably lower bone densities than did mice with normal levels of this protein [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

The association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and the risk of osteoporosis among U.S. adults: analysis of NHANES data

Wang,

Li,

et al. 2024

Lipids Health Dis

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Background Osteoporosis and atherosclerosis frequently afflict older adults, and recent insights suggest a deeper connection between these conditions that surpasses mere aging effects. The ratio of non-high-density to high-density lipoprotein cholesterol (NHHR) has emerged as a novel lipid marker for evaluating the risk of cardiovascular diseases. Nonetheless, investigations into the correlation of the NHHR with the risk of developing osteoporosis remain unexplored. Methods We collected NHHR and bone mineral density (BMD) data from 11,024 National Health and Nutrition Examination Survey (NHANES) participants between 2011 and 2018. Multivariate linear regression was employed to examine the correlation between BMD and NHHR. Smooth curves were employed to deal with the nonlinearity. To further account for the nonlinear link, we used a two-part linear regression model. The threshold effects were estimated using two components of a linear regression model. Subgroup and sensitivity analyses were carried out to ascertain the stability of the findings. Results We discovered a negative relationship between the NHHR and lumbar spine BMD in all three models. An L-shaped curvilinear association existed between the NHHR and lumbar spine BMD, with a key inflection point of 6.91. The fully adjusted model showed that the BMD of the lumbar spine fell by 0.03 g/cm2 in those who were in the fourth quartile as opposed to the lowest quartile. The sensitivity analysis using unweighted logistic analysis verified the stability of the results. In addition, BMD in the nondiabetic group was more significantly affected by the negative effect of the NHHR in the subgroup analysis. Conclusions According to this research, there appears to be a negative correlation between BMD and NHHR in US Adults. To clarify the precise physiological mechanisms by which the NHHR contributes to the onset of osteoporosis, more research is necessary.

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Section: Discussionmentioning

confidence: 99%

The association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and the risk of osteoporosis among U.S. adults: analysis of NHANES data

Wang,

Li,

et al. 2024

Lipids Health Dis

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“…30 High-cholesterol diets in rodents have also been associated with reduced bone mineral density and osteocalcin through the Hedgehog signaling pathway. 8,9,31,32 As a corollary, mice deficient in apolipoprotein A-1, a modulator of cholesterol transport and balance, had lesser differentiation of mesenchymal stem cells to osteoblasts and greater differentiation to adipocyte progenitors. 33 Whether LDL cholesterol itself or resultant atherosclerotic plaques impair bone formation, the findings of our study expand on established literature exploring the correlation between hypercholesterolemia and spine pathology.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, LDL cholesterol was found to stimulate osteoclastogenesis through receptor activator of nuclear factor κ-B ligand upregulation in human osteoblasts 30 . High-cholesterol diets in rodents have also been associated with reduced bone mineral density and osteocalcin through the Hedgehog signaling pathway 8,9,31,32 . As a corollary, mice deficient in apolipoprotein A-1, a modulator of cholesterol transport and balance, had lesser differentiation of mesenchymal stem cells to osteoblasts and greater differentiation to adipocyte progenitors 33 .…”

Section: Discussionmentioning

confidence: 99%

“…Animal studies have shown that rodents with high cholesterol and fat diets have increased bone loss and decreased bone formation. 8 In addition, pregnant mice fed a high-cholesterol diet had offspring with reduced osteoblast activity and osteogenesis. 9 As osseointegration is crucial to proper healing after fusion surgery, 10 its potential relationship with hypercholesterolemia warrants investigation in the context of pseudarthrosis.…”

mentioning

confidence: 99%

“…A persistent reduction in blood supply to the site of surgery and adjacent structures may increase the risk of pseudarthrosis. Animal studies have shown that rodents with high cholesterol and fat diets have increased bone loss and decreased bone formation 8 . In addition, pregnant mice fed a high-cholesterol diet had offspring with reduced osteoblast activity and osteogenesis 9 .…”

mentioning

confidence: 99%

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Low-Density Lipoprotein Cholesterol and Statin Usage Are Associated With Rates of Pseudarthrosis Following Single-Level Posterior Lumbar Interbody Fusion

Lavu,

Eghrari,

Makineni

et al. 2023

Spine

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Study design. Retrospective cohort study Objective. To investigate the relationships of low-density lipoprotein (LDL) cholesterol and statin usage with pseudarthrosis following single-level posterior or transforaminal lumbar interbody fusion (PLIF/TLIF). Summary of background data. Hypercholesterolemia can lead to atherosclerosis of the segmental arteries which branch into vertebral bone through intervertebral foramina. According to the vascular hypothesis of disc disease, this can lead to ischemia of lumbar discs and contribute to lumbar degenerative disease. Yet, little has been reported regarding the effects of cholesterol and statins on the outcomes of lumbar fusion surgery. Methods. TriNetX, a global federated research network, was retrospectively queried to identify 52,140 PLIF/TLIF patients between 2002 and 2021. Of these patients, 2,137 had high cholesterol (≥ 130 mg/dL) and 906 (≤ 55 mg/dL) had low cholesterol. Perioperatively, 18,275 patients used statins, while 33,415 patients did not. One-to-one propensity score matching for age, sex, race, and comorbidities was conducted to balance the analyzed cohorts. The incidence of pseudarthrosis was then assessed in the matched cohorts within the 6-month, 1-year, and 2-year postoperative periods. Results. After propensity score matching, high cholesterol patients had greater odds of developing pseudarthrosis 6 months (OR: 1.73, 95% CI: 1.28-2.33), 1 year (OR: 1.59, 95% CI: 1.20-2.10), and 2 years (OR: 1.57, 95% CI: 1.20-2.05) following a PLIF/TLIF procedure. Patients with statin usage had significantly lower odds of developing pseudarthrosis 6 months (OR: 0.74, 95% CI: 0.69-0.79), 1 year (OR: 0.76, 95% CI: 0.71-0.81), and 2 years (OR: 0.77, 95% CI: 0.72-0.81) following single-level PLIF/TLIF. Conclusions. Our findings suggest that patients with hypercholesterolemia is associated with an increased risk of developing pseudarthrosis following PLIF/TLIF while statin use is associated with a decreased risk. The data presented may underscore an overlooked opportunity for perioperative optimization in lumbar fusion patients, warranting further investigation in this area.

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Effects of different processing degrees of plant-based meat on the blood biochemical level, inflammation and intestinal microorganisms in mice

Liu,

Shi,

Wang

et al. 2023

Food Research International

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Cholesterol and fat in diet disrupt bone and tooth homeostasis in mice

Cited by 9 publications

References 28 publications

The association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and the risk of osteoporosis among U.S. adults: analysis of NHANES data

The association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and the risk of osteoporosis among U.S. adults: analysis of NHANES data

Low-Density Lipoprotein Cholesterol and Statin Usage Are Associated With Rates of Pseudarthrosis Following Single-Level Posterior Lumbar Interbody Fusion

Effects of different processing degrees of plant-based meat on the blood biochemical level, inflammation and intestinal microorganisms in mice

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