Cholesterol- and lanolin-rich diets may protect against steroid-induced osteonecrosis in rabbits

Zhao, Garida; Yamamoto, Takuaki; Motomura, Goro; Yamaguchi, Ryosuke; Ikemura, Satoshi; Iwasaki, Kenyu; Iwamoto, Yukihide

doi:10.3109/17453674.2013.859421

Cited by 16 publications

(14 citation statements)

References 17 publications

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“…Low-level evidence has shown protective effects of cholesterol-rich diets 149 , lipoic acid 150 , and enoxaparin for preventing disease progression 136 . Statins 142,151,152 , agents that target thrombosis and lipid deposition 153 , angiogenic and growth factors 154,155 , antiapoptotic factors 156 , herbal remedies 157 , and others 135,158-160 have been studied, but the results remain inconclusive.…”

Section: Nonoperative Therapymentioning

confidence: 99%

Nontraumatic Osteonecrosis of the Femoral Head: Where Do We Stand Today?

Mont

Cherian

Sierra

et al. 2015

The Journal of Bone and Joint Surgery

456

436

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➤ Although multiple theories have been proposed, no one pathophysiologic mechanism has been identified as the etiology for the development of osteonecrosis of the femoral head. However, the basic mechanism involves impaired circulation to a specific area that ultimately becomes necrotic.➤ A variety of nonoperative treatment regimens have been evaluated for the treatment of precollapse disease, with varying success. Prospective, multicenter, randomized trials are needed to evaluate the efficacy of these regimens in altering the natural history of the disease.➤ Joint-preserving procedures are indicated in the treatment of precollapse disease, with several studies showing successful outcomes at mid-term and long-term follow-up.➤ Studies of total joint arthroplasty, once femoral head collapse is present, have described excellent outcomes at greater than ten years of follow-up, which is a major advance and has led to a paradigm shift in treating these patients.➤ The results of hemiresurfacing and total resurfacing arthroplasty have been suboptimal, and these procedures have restricted indications in patients with osteonecrosis of the femoral head.

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Section: Nonoperative Therapymentioning

confidence: 99%

Nontraumatic Osteonecrosis of the Femoral Head: Where Do We Stand Today?

Mont

Cherian

Sierra

et al. 2015

The Journal of Bone and Joint Surgery

456

436

View full text Add to dashboard Cite

show abstract

“…All of these factors are important to consider when judiciously using steroids in the clinical setting. Zhao et al [82] and Kang et al [29] induced SONFH in male Japanese white rabbits with a single intramuscular injection of MPLS (20 mg / kg). The incidence of ONFH was 75% and 70% after two weeks respectively.…”

Section: Glucocorticoid Steroids Alone Modelingmentioning

confidence: 99%

Animal models of steroid-induced osteonecrosis of the femoral head—a comprehensive research review up to 2018

Gong

et al. 2018

International Orthopaedics (SICOT)

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Osteonecrosis of the femoral head (ONFH) is a significant cause of both pain and disability that often affects young adults during what ought to be their most productive age. Two broad categories of ONFH exist: traumatic and non-traumatic. Traumatic ONFH results from acute mechanical disruption of the femoral head's blood supply. Many factors that increase the risk of non-traumatic osteonecrosis have been identified. Steroid-induced osteonecrosis of the femoral head (SONFH) is the most common form of non-traumatic ONFH. Many hypotheses as to the pathogenesis of SONFH have been proposed, including intravascular thrombosis, abnormal fat metabolism, intramedullary adipocyte hypertrophy, and osteoporosis; however, the exact mechanism of SONFH is still not clearly understood. Animal models using rats, mice, rabbits, chickens, pigs, and emus have been used to study SONFH. Unfortunately, these models each have limitations. Therefore, it is necessary to establish a reproducible model that better simulates human disease. The present review is intended to summarize the currently available models, evaluative indicators, and application of current understanding to both the prevention and treatment of SONFH.

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“…There are also some studies that reported protective effects of lanosterol, pentosan, and pravastatin against ONFH 28,36,42) .…”

Section: Pt Aptt and Inr Resultsmentioning

confidence: 99%

The Effect of Cape on Steroid Induced Osteonecrosis of the Femoral Head in Rat Model

Uruç

Duman

Davul

et al. 2018

J. Hard Tissue Biology.

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The aim of this experimental study was to examine the eff ect of Caff eic acid phenethyl ester (CAPE) on steroidinduced osteonecrosis of femoral head (ONFH) in rats. Thirty-one male Wistar albino rats were divided into 4 groups: control group (7 rats), methylprednisolone treatment group (MPS, 8 rats), CAPE treatment group (8 rats) and MPS+CAPE administered group (8 rats). The rats of group MPS and CAPE+MPS, On days 2, 3 and 4 were treated with 20 mg/kg/ day methylprednisolone (MPS; Pfizer Pharmaceutical, Puurs, Belgium) intramuscularly. 10 μmol/kg/day CAPE was intraperitoneally injected to the rats of group CAPE from 13 weeks of age for 4 weeks. The control group was fed and housed under identical conditions without any treatment. All rats were sacrifi ced at 17 weeks of age by taking blood from the heart. Both proximal femoral parts were taken for histopathological and immunohistochemical analysis . Total oxidant status, total antioxidant status, and oxidative stress index (OSI), lipid parameters, coagulation parameters were assessed in blood specimens. Much lesser amount of osteonecrosis lesions were observed in the MPS+CAPE group compared to MPS group. In immunhisochemical analysis, oxidative stress was found signifi cantly decreased in CAPE+MPS group compared to MPS group. OSI levels were signifi cantly decreased in CAPE+MPS group compared to MPS group (p<0.001). In CAPE+MPS group lipid and coagulation parameters were found positively aff ected compared to MPS group. In conclusion, CAPE has strong protective eff ect against the steroid induced femoral head osteonecrosis in rats.

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Cholesterol- and lanolin-rich diets may protect against steroid-induced osteonecrosis in rabbits

Cited by 16 publications

References 17 publications

Nontraumatic Osteonecrosis of the Femoral Head: Where Do We Stand Today?

Nontraumatic Osteonecrosis of the Femoral Head: Where Do We Stand Today?

Animal models of steroid-induced osteonecrosis of the femoral head—a comprehensive research review up to 2018

The Effect of Cape on Steroid Induced Osteonecrosis of the Femoral Head in Rat Model

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