Cholesterol and Phosphatide Metabolism in Pregnancy

Baumann, Emil J.; Holly, Olive M.

doi:10.1152/ajplegacy.1926.75.3.618

Cited by 23 publications

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“…39). Depressed concentrations of lipid in rabbit plasma during pregnancy have been reported (40). Subsequently, Zilversmit et al (41) reported that the total amounts of cholesterol, phospholipid, and all lipoproteins decreased in the latter half of pregnancy.…”

Section: Discussionmentioning

confidence: 95%

Platelet-activating factor acetylhydrolase activity in maternal, fetal, and newborn rabbit plasma during pregnancy and lactation.

Maki

Hoffman

Johnston

1988

Proc. Natl. Acad. Sci. U.S.A.

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The inactivation of the biologically active ether-containing glycerophospholipid platelet-activating factor (PAF) is catalyzed by the enzyme PAF acetylhydrolase (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase, EC 3.1.1.48). The specific activity of acetylhydrolase has been assayed in maternal rabbit plasma prior to and throughout pregnancy and after parturition. The specific activity of acetylhydrolase was 131 + 8 nmol-min -'ml'-of plasma (mean ± SEM) in the nonpregnant rabbit. Similar specific activities were found throughout the first half of pregnancy; however, on day 15 the acetylhydrolase activity began to decrease and reached a minimum around day 27. Within 24-48 hr following delivery, the specific activity of the enzyme increased to the levels found in the nonpregnant animals. The specific activity of acetylhydrolase in fetuses (gestational ages of 21-30 days) and neonates increased from 22 nmol min'-1 ml-1 of plasma (21-day-old) to 328 nmolinin ml' of plasma (35-day-old rabbits). The decrease in enzymatic activity of the pregnant rabbit plasma cannot be accounted for by the presence of an inhibitor as determined by plasma-mixing experiments with nonpregnant and pregnant (27-day) plasma. The properties of this enzyme in the rabbit were consistent with those reported by others, i.e., substrate specificity, inactivation by heat and various inhibitors, and Ca2" inde-

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Section: Discussionmentioning

confidence: 95%

Platelet-activating factor acetylhydrolase activity in maternal, fetal, and newborn rabbit plasma during pregnancy and lactation.

Maki

Hoffman

Johnston

1988

Proc. Natl. Acad. Sci. U.S.A.

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“…INDEXING KEY WORDS terol â€¢ rabbit fetal growth â€¢ placental permeability â€¢ choles-Some years ago we observed that when hypercholesterolemic rabbits became preg nant very few of their young were born alive. Although the effect of pregnancy on serum cholesterol concentration in the rabbit has been described (1,2) little in formation appears to be available on the relation of serum cholesterol concentration to the development of the fetus. Popjak (2) reported that the feeding of cholesterol to rabbits for a relatively short period of time leads to accumulation of this lipid in the fetal portion of the placenta.…”

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confidence: 99%

Fetal Growth and Placental Permeability in Rabbits Fed Cholesterol

Zilversmit¹,

Remington²,

Hughes³

1972

The Journal of Nutrition

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Rabbits fed cholesterol before and during pregnancy showed a high fetal mortality. Decreasing the dose and duration of cholesterol feeding decreased this mortality. Successful insemination in cholesterol-fed does was less frequent than in control animals. Fetuses from cholesterol-fed does weighed significantly less than those from control does, but newborn young did not show a significant difference in birth weight. Placentas from cholesterol-fed does showed greatly increased concentrations of cholesterol, particularly in the esterified form. Placental transfer of 131Imeasured in vivo did not show significant differences as a result of cholesterol feeding.

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Protective Effect of Cholesterol in Experimental Epilepsy

Aird¹,

Gurchot²

1939

Arch NeurPsych

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Cholesterol and Phosphatide Metabolism in Pregnancy

Cited by 23 publications

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Platelet-activating factor acetylhydrolase activity in maternal, fetal, and newborn rabbit plasma during pregnancy and lactation.

Platelet-activating factor acetylhydrolase activity in maternal, fetal, and newborn rabbit plasma during pregnancy and lactation.

Fetal Growth and Placental Permeability in Rabbits Fed Cholesterol

Protective Effect of Cholesterol in Experimental Epilepsy

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