Cholesterol and sphingolipids as lipid organizers of the immune cells’ plasma membrane: Their impact on the functions of MHC molecules, effector T-lymphocytes and T-cell death

Gombos, Imre; Kiss, Еndre; Detre, Cynthia; László, Glória; Matkó, János

doi:10.1016/j.imlet.2005.11.021

Cited by 36 publications

(30 citation statements)

References 129 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this context, cholesterol and sphingolipids have also been investigated in order to assess their impact on MHC function and immunological synapse formation. They have been considered as supervisors of the plasma membrane of immune cells [56]. For instance, in type I cells, CD59 and CD55 surface receptors appear as localized into different lipid submicrodomains with respect to CD28 [57].…”

Section: The Role Of Lipid Rafts In Apoptosismentioning

confidence: 99%

Dynamics of lipid raft components during lymphocyte apoptosis: The paradigmatic role of GD3

et al. 2007

View full text Add to dashboard Cite

Several investigations have been carried out since many years in order to precisely address the function of lipid rafts in cell life and death. On the basis of the biochemical nature of lipid rafts, composed by sphingolipids, including gangliosides, sphingomyelin, cholesterol and signaling proteins, a plethora of possible interactions with various subcellular structures has been suggested. Their structural and functional role at the plasma membrane as well as in cell organelles such as endoplasmic reticulum and Golgi apparatus has been analyzed in detail in several studies. In particular, a specific activity of lipid rafts has been hypothesized to contribute to cell death by apoptosis. Although detected in various cell types, the role of lipid rafts in apoptosis has however been mostly studied in lymphocytes where the physiological apoptotic program occurs after CD95/Fas triggering. In this review, the possible contribution of lipid rafts to the cascade of events leading to T cell apoptosis after CD95/Fas ligation are summarized. Particular attention has been given to the mitochondrial raft-like microdomains, which may represent preferential sites where some key reactions can take place and can be catalyzed, leading to either survival or death of T cells.

show abstract

Section: The Role Of Lipid Rafts In Apoptosismentioning

confidence: 99%

Dynamics of lipid raft components during lymphocyte apoptosis: The paradigmatic role of GD3

et al. 2007

View full text Add to dashboard Cite

show abstract

“…In immune cells, components of microdomains are recruited to sites of antigen presentation in the immunological synapse-an adhesion and signaling site of immune cells-and affect cell signaling [7]. Further, it has been suggested that sphingolipids such as ceramide may be important in a T cell response.…”

Section: Introductionmentioning

confidence: 99%

The role of membrane microdomains in transmembrane signaling through the epithelial glycoprotein Gp140/CDCP1

Alvares

Dunn

Brown

et al. 2008

Biochimica et Biophysica Acta (BBA) - General Subjects

View full text Add to dashboard Cite

Cell adhesion to the extracellular matrix (ECM) via integrin adhesion receptors initiates signaling cascades leading to changes in cell behavior. While integrin clustering is necessary to initiate cell attachment to the matrix, additional membrane components are necessary to mediate the transmembrane signals and the cell adhesion response that alter downstream cell behavior. Many of these signaling components reside in glycosphingolipid-rich and cholesterol-rich membrane domains such as Tetraspanin Enriched Microdomains (TEMs)/Glycosynapse 3 and DetergentResistant Microdomains (DRMs), also known as lipid rafts. In the following article, we will review examples of how components in these membrane microdomains modulate integrin adhesion after initial attachment to the ECM. Additionally, we will present data on a novel adhesion-responsive transmembrane glycoprotein Gp140/CUB Domain Containing Protein 1, which clusters in epithelial cell-cell contacts. Gp140 can then be phosphorylated by Src Family Kinases at tyrosine 734 in response to outside-in signals-possibly through interactions involving the extracellular CUB domains. Data presented here suggests that outside-in signals through Gp140 in cell-cell contacts assemble membrane clusters that associate with membrane microdomains to recruit and activate SFKs. Active SFKs then mediate phosphorylation of Gp140, SFK and PKCδ with Gp140 acting as a transmembrane scaffold for these kinases. We propose that the clustering of Gp140 and signaling components in membrane microdomains in cell-cell contacts contributes to changes in cell behavior.

show abstract

“…Rafts are involved in protein trafficking/protein-complex formation/signal transduction/apoptosis/cell adhesion/stress responses/cytoskeleton regulation/conduction of proatherogenic stimuli, and affect immune function (13)(14)(15). Rafts are portals of entry for toxins/viruses/bacteria (16,17), are important for normal synapse density/morphology, and myelin integrity/myelin-axon interactions (18).…”

mentioning

confidence: 99%

CLN3p Impacts Galactosylceramide Transport, Raft Morphology, and Lipid Content

et al. 2008

View full text Add to dashboard Cite

show abstract

Cholesterol and sphingolipids as lipid organizers of the immune cells’ plasma membrane: Their impact on the functions of MHC molecules, effector T-lymphocytes and T-cell death

Cited by 36 publications

References 129 publications

Dynamics of lipid raft components during lymphocyte apoptosis: The paradigmatic role of GD3

Dynamics of lipid raft components during lymphocyte apoptosis: The paradigmatic role of GD3

The role of membrane microdomains in transmembrane signaling through the epithelial glycoprotein Gp140/CDCP1

CLN3p Impacts Galactosylceramide Transport, Raft Morphology, and Lipid Content

Contact Info

Product

Resources

About