2023
DOI: 10.1186/s13578-023-01127-y
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Cholesterol-dependent amyloid β production: space for multifarious interactions between amyloid precursor protein, secretases, and cholesterol

Vladimir Rudajev,
Jiri Novotny

Abstract: Amyloid β is considered a key player in the development and progression of Alzheimer’s disease (AD). Many studies investigating the effect of statins on lowering cholesterol suggest that there may be a link between cholesterol levels and AD pathology. Since cholesterol is one of the most abundant lipid molecules, especially in brain tissue, it affects most membrane-related processes, including the formation of the most dangerous form of amyloid β, Aβ42. The entire Aβ production system, which includes the amylo… Show more

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Cited by 12 publications
(1 citation statement)
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“…As a major component of the plasma membrane and of its well-known microdomains lipid rafts, cholesterol, in coordination with sphingolipids, ensures the correct oligomerization and functioning of several membrane proteins, such as caveolins, thus regulating APP and tau processing and synaptic transmission. Moreover, it regulates neurite outgrowth, it is an essential constituent of myelin sheath, and it is fundamental for axonal growth, synaptic formation, and plasticity [8,[38][39][40].…”
Section: Discussionmentioning
confidence: 99%
“…As a major component of the plasma membrane and of its well-known microdomains lipid rafts, cholesterol, in coordination with sphingolipids, ensures the correct oligomerization and functioning of several membrane proteins, such as caveolins, thus regulating APP and tau processing and synaptic transmission. Moreover, it regulates neurite outgrowth, it is an essential constituent of myelin sheath, and it is fundamental for axonal growth, synaptic formation, and plasticity [8,[38][39][40].…”
Section: Discussionmentioning
confidence: 99%