Cholesterol efflux regulator ABCA1 exerts protective role against high shear stress-induced injury of HBMECs via regulating PI3K/Akt/eNOS signaling

Li, Zhe; Li, Jianan; Li, Qiang; Li, Chun; Zhou, Lin-Hua; Zhang, Qi; Xu, Yi

doi:10.1186/s12868-022-00748-2

Cited by 3 publications

(2 citation statements)

References 60 publications

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“…It has been reported that VEGFA affects the development of AS by regulating lipid metabolism [ 30 ] and endothelial function [ 31 ]. Moreover, CTNNB1, MMP9, and EGFR have been shown to regulate AS by affecting the formation and stability of plaques through antioxidation and apoptosis inhibition [ 32 , 33 ]. Molecular docking is an important technique for discovering new medicines and improving existing drugs.…”

Section: Discussionmentioning

confidence: 99%

Network pharmacology and in vivo evidence of the pharmacological mechanism of geniposide in the treatment of atherosclerosis

Ma,

Dong,

et al. 2024

BMC Complement Med Ther

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Background Atherosclerosis (AS) is a fundamental pathological state in various cardiovascular diseases. Geniposide, which is the main active component of Gardenia jasminides, is effective against AS. However, the underlying molecular mechanisms remain unclear. Here, we sought to elucidate them. Methods The targets of AS and geniposide were collected from online public databases. The potential mechanism of Geniposide in treating AS was predicted by constructing a protein–protein interaction (PPI) network and conducting Gene Ontology (GO) and Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway enrichment analyses. Hub proteins and core pathways were verified by molecular docking and in vivo experiments. Moreover, the effect of geniposide on AS was assessed by measuring the atherosclerotic plaque area in the thoracic aorta of mice. ApoE−/− mice were used to establish AS models and randomly divided into different groups. Two different doses of geniposide were administered to the mice. Hematoxylin and eosin (HE) staining was performed to evaluate the effects of geniposide on AS. Oil Red O and Sirius Red staining were used to evaluate plaque stability. The protein expression of key markers involved in the signalling pathways was examined using western blotting and immunofluorescence. Results A total of 239 active targets, 3418 AS-related disease targets, and 129 overlapping targets were identified. Hub genes were detected, and molecular docking revealed that geniposide strongly interacted with hub proteins (AKT1, VEGFA, CTNNB1, MMP9, and EGFR). Moreover, 109 signalling pathways, including the Rap1 signalling pathway, were identified using enrichment analysis. The results of in vivo experiments demonstrated that geniposide reduced body weight and blood lipid levels, alleviated the formation of atherosclerotic plaques, enhanced plaque stability, and inhibited inflammation, at least partially, by activating the Rap1/PI3K/Akt signalling pathway in ApoE−/− mice. Conclusion Geniposide can alleviate AS and enhance the stability of atherosclerotic plaques by regulating the Rap1/PI3K/Akt signalling pathway.

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Section: Discussionmentioning

confidence: 99%

Network pharmacology and in vivo evidence of the pharmacological mechanism of geniposide in the treatment of atherosclerosis

Ma,

Dong,

et al. 2024

BMC Complement Med Ther

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“…The efficient energy storage technology, which requires several kinds of critical metals, is expected to well solve the problem caused by photovoltaic power generation and wind power generation characterized by strong intermittency and high volatility. Lithiumion batteries with low cost, high efficiency, and fast response time are ahead of other energy storage technologies (Li et al, 2022). Future energy storage technologies will focus on the development of lithiumion batteries.…”

Section: Introductionmentioning

confidence: 99%

Assessing the supply risk of geopolitics on critical minerals for energy storage technology in China

Wang

Li-mao²,

Zhong³

et al. 2023

Front. Energy Res.

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Energy storage technology as a key support technology for China’s new energy development, the demand for critical metal minerals such as lithium, cobalt, and nickel is growing rapidly. However, these minerals have high external dependence and concentrated import sources, increasing the supply risk caused by geopolitics. It is necessary to evaluate the supply risks of critical metal minerals caused by geopolitics to provide a basis for the high-quality development of energy storage technology in China. Based on geopolitical data of eight countries from 2012 to 2020, the evaluation indicators such as geopolitical stability, supply concentration, bilateral institutional relationship, and country risk index were selected to analyze the supply risk of three critical metal minerals, and TOPSIS was applied to construct an evaluation model for the supply risk of critical metal minerals of lithium, cobalt, and nickel in China. The results show that from 2012 to 2017, the security index of cobalt and lithium resources is between .6 and .8, which is in a relatively safe state, while the security index of nickel resources is .2–.4, which is in an unsafe state. From 2017 to 2020, lithium resources remain relatively safe, and the security index of nickel has also risen to between .6 and .7, which is generally in a relatively safe state. However, the security index of cobalt has dropped to .2, which is in an unsafe or extremely unsafe state. Therefore, China needs to pay attention to the safe supply of cobalt resources and formulate relevant strategies to support the large-scale development of energy storage technology.

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The role of the ATP-Binding Cassette A1 (ABCA1) in neurological disorders: a mechanistic review

Paseban,

Alavi,

Etemad

et al. 2023

Expert Opinion on Therapeutic Targets

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Cholesterol efflux regulator ABCA1 exerts protective role against high shear stress-induced injury of HBMECs via regulating PI3K/Akt/eNOS signaling

Cited by 3 publications

References 60 publications

Network pharmacology and in vivo evidence of the pharmacological mechanism of geniposide in the treatment of atherosclerosis

Network pharmacology and in vivo evidence of the pharmacological mechanism of geniposide in the treatment of atherosclerosis

Assessing the supply risk of geopolitics on critical minerals for energy storage technology in China

The role of the ATP-Binding Cassette A1 (ABCA1) in neurological disorders: a mechanistic review

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