Cholesterol embolization syndrome: report of two cases

Dizman, Nazlı; Bahat, Kübra Aydın; Özkanlı, Şeyma; Özkök, Abdullah

doi:10.5543/tkda.2015.94587

Cited by 4 publications

(2 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CES manifests later than CI-AKI, usually 1-2 wk after the procedure. Dislodgement of cholesterol crystals from the atherosclerotic plaques leads to embolization of the small peripheral arterioles causing a multisystemic disease with allergic-immunological features including eosinophilia, hypocomplementemia, livedo reticularis, distal gangrenes with palpable pulses (blue-toe syndrome) and pathognomonic Hollenhorst plaques on ophthalmologic examination[91]. Renal biopsy reveals empty clefts within the obliterated lumens of the arterioles[90].…”

Section: Cesmentioning

confidence: 99%

Contrast-induced acute kidney injury: A review of practical points

Özkök¹,

Özkök²

2017

WJN

Self Cite

121

View full text Add to dashboard Cite

Contrast-induced acute kidney injury (CI-AKI) is one of the most common causes of AKI in clinical practice. CI-AKI has been found to be strongly associated with morbidity and mortality of the patients. Furthermore, CI-AKI may not be always reversible and it may be associated with the development of chronic kidney disease. Pathophysiology of CI-AKI is not exactly understood and there is no consensus on the preventive strategies. CI-AKI is an active research area thus clinicians should be updated periodically about this topic. In this review, we aimed to discuss the indications of contrast-enhanced imaging, types of contrast media and their impact on nephrotoxicity, major pathophysiological mechanisms, risk factors and preventive strategies of CI-AKI and alternative non-contrast-enhanced imaging methods.

show abstract

Section: Cesmentioning

confidence: 99%

Contrast-induced acute kidney injury: A review of practical points

Özkök¹,

Özkök²

2017

WJN

Self Cite

121

View full text Add to dashboard Cite

show abstract

“…Hemodynamic changes, inflammation, and intraplaque hemorrhage, which may occur spontaneously or due to invasive procedures, may induce plaque erosion and rupture that expose the components of the plaque to systemic circulation. Subsequent showering of CCs to distal circulation leads to obstruction of arterioles with diameters of 100–200 μm 17…”

Section: Pathophysiology Of Cesmentioning

confidence: 99%

<p>Cholesterol-embolization syndrome: current perspectives</p>

Özkök¹

2019

VHRM

Self Cite

View full text Add to dashboard Cite

Cholesterol-embolization syndrome (CES) is a multisystemic disease with various clinical manifestations. CES is caused by embolization of cholesterol crystals (CCs) from atherosclerotic plaques located in the major arteries, and is induced mostly iatrogenically by interventional and surgical procedures; however, it may also occur spontaneously. Embolized CCs lead to both ischemic and inflammatory damage to the target organ. Therefore, anti-inflammatory agents, such as corticosteroids and cyclophosphamide, have been investigated as treatment for CES in several studies, with conflicting results. Recent research has revealed that CES is actually a kind of autoinflammatory disease in which inflammasome pathways, such as NLRP3 and IL1, are induced by CCs. These recent findings may have clinical implications such that colchicine and IL1 inhibitors, namely canakinumab, may be beneficial in the early stages of CES.

show abstract

“Purple Toe: A Syndrome from Head to Toe”

2016

JCCR

View full text Add to dashboard Cite

Cholesterol crystal embolization is a rare multisystem disorder that originates from atherosclerotic plaques showering to different sites causing end organ damage. We present a 79-year-old man who developed purple discoloration of the left toe. Physical exam revealed tender purple toes with palpable distal pulses. The diagnosis of cholesterol emboli syndrome was made while differential diagnoses were ruled out. Despite medical management, his condition continued to slowly worsen.

show abstract

Cholesterol embolization syndrome: report of two cases

Cited by 4 publications

References 20 publications

Contrast-induced acute kidney injury: A review of practical points

Contrast-induced acute kidney injury: A review of practical points

<p>Cholesterol-embolization syndrome: current perspectives</p>

“Purple Toe: A Syndrome from Head to Toe”

Contact Info

Product

Resources

About