Cholesterol gallstones: Focusing on the role of interstitial Cajal-like cells

Fu, Binying; Zhao, Jianwen; Wu, Shuodong; Fan, Ying

doi:10.12998/wjcc.v9.i15.3498

Cited by 5 publications

(3 citation statements)

References 44 publications

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“…Cholecystic contractile function is enhanced as the CCK level increases; a decrease in the CCK level and its concomitant gallbladder contraction dysfunction are important pathological mechanisms leading to the formation of gallstones[ 21 ]. CCK-A receptors are found in gallbladder smooth muscle, and CCK binding to CCK-A receptors plays a vital role in gallbladder motility.…”

Section: Discussionmentioning

confidence: 99%

Expression and functional study of cholecystokinin-A receptors on the interstitial Cajal-like cells of the guinea pig common bile duct

Xu,

Ma,

Huang

et al. 2023

World J Gastroenterol

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Intraductal papillary neoplasms of the bile duct (IPNBs) represent a rare variant of biliary tumors characterized by a papillary growth within the bile duct lumen. Since their first description in 2001, several classifications have been proposed, mainly based on histopathological, radiological and clinical features, although no specific guidelines addressing their management have been developed. Bile duct neoplasms generally develop through a multistep process, involving different precursor pathways, ranging from the initial lesion, detectable only microscopically, i.e. biliary intraepithelial neoplasia, to the distinctive grades of IPNB until the final stage represented by invasive cholangiocarcinoma. Complex and advanced investigations, mainly relying on magnetic resonance imaging (MRI) and cholangioscopy, are required to reach a correct diagnosis and to define an adequate bile duct mapping, which supports proper treatment. The recently introduced subclassifications of types 1 and 2 highlight the histopathological and clinical aspects of IPNB, as well as their natural evolution with a particular focus on prognosis and survival. Aggressive surgical resection, including hepatectomy, pancreaticoduodenectomy or both, represents the treatment of choice, yielding optimal results in terms of survival, although several endoscopic approaches have been described. IPNBs are newly recognized preinvasive neoplasms of the bile duct with high malignant potential. The novel subclassification of types 1 and 2 defines the histological and clinical aspects, prognosis and survival. Diagnosis is mainly based on MRI and cholangioscopy. Surgical resection represents the mainstay of treatment, although endoscopic resection is currently applied to nonsurgically fit patients. New frontiers in genetic research have identified the processes underlying the carcinogenesis of IPNB, to identify targeted therapies.

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Section: Discussionmentioning

confidence: 99%

Expression and functional study of cholecystokinin-A receptors on the interstitial Cajal-like cells of the guinea pig common bile duct

Xu,

Ma,

Huang

et al. 2023

World J Gastroenterol

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“…With advances in recent research, it has been found that Interstitial Cells of Cajal (ICCs) play an important role in maintaining the normal motility of the gallbladder ( Huang et al, 2009 ; Fu et al, 2021 ). For example, in guinea pigs with cholesterol cholelithiasis, the density and ultrastructure of ICCs in the gallbladder are altered ( Huang et al, 2021 ).…”

Section: Mechanisms Of Gallstone Formationmentioning

confidence: 99%

How traditional Chinese medicine can prevent recurrence of common bile duct stones after endoscopic retrograde cholangiopancreatography?

Bian,

Zhang,

Yao

et al. 2024

Front. Pharmacol.

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Common bile duct stones, as a type of cholelithiasis, are a benign biliary obstruction that easily acute abdominalgia, and Endoscopic Retrograde Cholangiopancreatography (ERCP) is usually the first choice for clinical treatment. However, the increasing recurrence rate of patients after treatment is troubling clinicians and patients. For the prevention of recurrence after ERCP, there is no guideline to provide a clear drug regimen, traditional Chinese medicine however has achieved some result in the treatment of liver-related diseases based on the “gut-liver-bile acid axis”. On the basis of this, this article discusses the possibility of traditional Chinese medicine to prevent common bile duct stones (CBDS) after ERCP, and we expect that this article will provide new ideas for the prevention of recurrence of CBDS and for the treatment of cholelithiasis-related diseases with traditional Chinese medicine in future clinical and scientific research.

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“…It has a large financial burden on the healthcare economy, and GDs are influenced by an interaction of complicated environmental and genetic factors [ 12 ]. About 10%–15% of the global adult population is influenced by GDs because it is a highly prevalent gastroenterological disorder [ 13 , 14 ]. It is not lethal, but it can result in severe GIT disorders leading to many serious complications and outcomes, such as pancreatitis, gallbladder cancer, and acute GSs [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Osteopontin (SPP1) expression on gallstone formation in rabbits fed with a lithogenic diet

Abdal,

Naemi

2023

J Adv Vet Anim Res

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Objective: This research was designed to assess the influence of the administration of a lithogenic diet, hydrogen peroxide, and vitamin AD3E on rabbits’ gallstone formation and to envisage the expression of osteopontin (OPN) in their hepatic tissues. Materials and Methods: Twenty-four healthy local mature rabbits of both genders were divided into four equal groups. At the end of the feeding period, samples of blood were taken from all rab¬bits after they had fasted overnight to estimate the serum lipid profile. And some of the hepatic tissue has been preserved at −28°C for molecular analysis and gene expression. Results: The gallstones were formed 100% in the GIII and 50% in the GIV. The mRNA OPN expression showed a significant increase in the GIII when compared with other groups. In Groups III and II, the serum levels of total cholesterol, Triglyceride, L-C, low-density lipoprotein-choles, and VLDL-C were significantly increased when compared with GI, while in GIII, the serum level of high-density lipoprotein-cholesterol was significantly decreased when compared with GI. Conclusion: It was concluded that the expression of the mRNA OPN was increased in the hepatic tissue of gallstone-formed rabbits.

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Cholesterol gallstones: Focusing on the role of interstitial Cajal-like cells

Cited by 5 publications

References 44 publications

Expression and functional study of cholecystokinin-A receptors on the interstitial Cajal-like cells of the guinea pig common bile duct

Expression and functional study of cholecystokinin-A receptors on the interstitial Cajal-like cells of the guinea pig common bile duct

How traditional Chinese medicine can prevent recurrence of common bile duct stones after endoscopic retrograde cholangiopancreatography?

Osteopontin (SPP1) expression on gallstone formation in rabbits fed with a lithogenic diet

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