Cholesterol Granuloma in Odontogenic Cyst: An Enigmatic Lesion

Kamboj, Mala; Devi, Anju; Gupta, Shruti

doi:10.1155/2016/6105142

Cited by 8 publications

(15 citation statements)

References 7 publications

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“…The presence of foreign body reaction with accumulation of cholesterol clefts involving macrophages and foreign body giant cells constituted the main feature ( Figure 1(d) ). The persistence of these cells may be the major source of cholesterol that is released by the destroyed membranes of these cells in chronic lesions [ 1 , 2 , 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…The pathogenesis of maxillary sinus CG is still uncertain and its occurrence has been reported secondarily to bleeding, inadequate lymphatic drainage, poor ventilation, trauma, surgery, sinusitis, and odontogenic lesions [ 3 , 7 , 11 , 12 ]. It has been suggested that inflamed odontogenic lesions could show a foreign body reaction to the cholesterol crystals in their capsule, and as the capsule expanded it may possibly reach the maxillary sinus [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

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Cholesterol Granuloma in the Maxillary Sinus: Are Endodontically Treated Teeth Involved in Its Etiopathogenesis?

Filho

Esteves

Oliveira

2017

Case Reports in Pathology

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Cholesterol granuloma (CG) is a tissue reaction in response to the accumulation of cholesterol crystals rarely found in the maxillary sinus. The etiopathogenesis of maxillary sinus CG remains unclear. We reviewed the literature and added two new reports of cholesterol granuloma in maxillary sinus related to endodontically treated maxillary posterior teeth. The first report refers to a 45-year-old woman diagnosed with rhinitis, who was submitted to endodontic retreatment of maxillary molar, and subsequently showed maxillary sinus opacity with cystic appearance. The second case describes a young adult woman, who presented a cystic mass in maxillary sinus after endodontic treatment, in close association with the apex of the maxillary right second premolar. Both patients were treated by a classic Caldwell-Luc surgery and the microscopic analyses revealed maxillary sinus CG. In the following, the authors discuss the probable involvement of endodontically treated maxillary posterior teeth in the etiopathogenesis of maxillary sinus CG.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cholesterol Granuloma in the Maxillary Sinus: Are Endodontically Treated Teeth Involved in Its Etiopathogenesis?

Filho

Esteves

Oliveira

2017

Case Reports in Pathology

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“…It is not uncommon that a cholesterol granuloma will form within a dentigerous cyst [ 3 ] or similar structure in response to an inflammatory insult, such as a tooth root infection; however, in this instance, the incomplete lining of the lesion was not obtained during the biopsy. The lack of both previous insults, mechanical or microbiological, marks this case as unusual, as nearly all previously reported cases had indications of prior trauma or infection associated with the region in which the cholesterol granuloma formed.…”

Section: Case Presentationmentioning

confidence: 99%

Cholesterol Granuloma: An Unusual Presentation Within the Mandible of a Pediatric Patient

Gosnell¹,

Sawatari²,

Qiu³

2022

Cureus

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Cholesterol granulomas, while a common pathological finding, are rarely reported within the mandible. Herein, we report the case of a pediatric patient who presented with a cholesterol granuloma within a periapical cyst, extending from the inferior aspect of tooth #31 to the mandibular condyle, with no prior history of infection or trauma to the region and underwent successful marsupialization of the lesion.

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“…Lipophagy was reported in lipid-laden macrophages (foam macrophages) (59, 60) and in memory CD8 T cells (61) in odontogenic cyst (62)(63)(64). IL-12 is important in CD8 T-cell clonal expansion in addition to the generation of memory CD8 T cells (65).…”

Section: Radicular Cystmentioning

confidence: 99%

“…IL-12 is important in CD8 T-cell clonal expansion in addition to the generation of memory CD8 T cells (65), which in turn stimulate lipophagy (Figure 8B). Lipophagy was reported in lipid-laden macrophages (foam macrophages) (59,60) in odontogenic cyst (63) and in memory CD8 T cells (61). Additionally, IL-12A inhibits VEGF and MMP-9 reducing angiogenesis (66).…”

Section: Radicular Cystmentioning

confidence: 99%

Comparative Metabolomics Reveals the Microenvironment of Common T-Helper Cells and Differential Immune Cells Linked to Unique Periapical Lesions

et al. 2021

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Periapical abscesses, radicular cysts, and periapical granulomas are the most frequently identified pathological lesions in the alveolar bone. While little is known about the initiation and progression of these conditions, the metabolic environment and the related immunological behaviors were examined for the first time to model the development of each pathological condition. Metabolites were extracted from each lesion and profiled using gas chromatography-mass spectrometry in comparison with healthy pulp tissue. The metabolites were clustered and linked to their related immune cell fractions. Clusters I and J in the periapical abscess upregulated the expression of MMP-9, IL-8, CYP4F3, and VEGF, while clusters L and M were related to lipophagy and apoptosis in radicular cyst, and cluster P in periapical granuloma, which contains L-(+)-lactic acid and ethylene glycol, was related to granuloma formation. Oleic acid, 17-octadecynoic acid, 1-nonadecene, and L-(+)-lactic acid were significantly the highest unique metabolites in healthy pulp tissue, periapical abscess, radicular cyst, and periapical granuloma, respectively. The correlated enriched metabolic pathways were identified, and the related active genes were predicted. Glutamatergic synapse (16–20),-hydroxyeicosatetraenoic acids, lipophagy, and retinoid X receptor coupled with vitamin D receptor were the most significantly enriched pathways in healthy control, abscess, cyst, and granuloma, respectively. Compared with the healthy control, significant upregulation in the gene expression of CYP4F3, VEGF, IL-8, TLR2 (P < 0.0001), and MMP-9 (P < 0.001) was found in the abscesses. While IL-12A was significantly upregulated in cysts (P < 0.01), IL-17A represents the highest significantly upregulated gene in granulomas (P < 0.0001). From the predicted active genes, CIBERSORT suggested the presence of natural killer cells, dendritic cells, pro-inflammatory M1 macrophages, and anti-inflammatory M2 macrophages in different proportions. In addition, the single nucleotide polymorphisms related to IL-10, IL-12A, and IL-17D genes were shown to be associated with periapical lesions and other oral lesions. Collectively, the unique metabolism and related immune response shape up an environment that initiates and maintains the existence and progression of these oral lesions, suggesting an important role in diagnosis and effective targeted therapy.

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Cholesterol Granuloma in Odontogenic Cyst: An Enigmatic Lesion

Cited by 8 publications

References 7 publications

Cholesterol Granuloma in the Maxillary Sinus: Are Endodontically Treated Teeth Involved in Its Etiopathogenesis?

Cholesterol Granuloma in the Maxillary Sinus: Are Endodontically Treated Teeth Involved in Its Etiopathogenesis?

Cholesterol Granuloma: An Unusual Presentation Within the Mandible of a Pediatric Patient

Comparative Metabolomics Reveals the Microenvironment of Common T-Helper Cells and Differential Immune Cells Linked to Unique Periapical Lesions

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