Cholesterol Granuloma of the Orbit

Abstract

Orbital CG is a rare expansive cystic condition and nearly always occurs in the lateral region of the superior orbital ridge within the frontal diploic space. This condition shows a marked preponderance in middle-aged males. The findings that computed tomography scan did not reveal bone erosion in patient 1, and magnetic resonance imaging examination showed moderate signal intensity, rather than high signal intensity, on T1-weighted images in patient 2 indicated that these represented unusual presentations. Surgical excision has a high success rate with a low incidence of recurrence.

Huge Cholesterol Granuloma in Nasoseptal Region

“…The MRI scans show characteristic high signal intensity on both T1-and T2-weighted images owing to its high-lipid cholesterol content, except for the walls of the cyst due to the accumulation of paramagnetic methemoglobin. [4][5][6] The differential diagnoses of CGs for the most part include the¼mucoceles and meningoceles. Mucoceles show low-and high-signal intensities on T1-and T2-weighted images, but signal characteristics may vary depending on their fluid contents.…”

“…2,3 Cholesterol granuloma may be precipitated by trauma, surgery, or recurrent sinusitis attacks leading to bleeding into a closed bony cavity and accumulation of blood in a space with interrupted ventilation. 1,2,4 The CGs are more common in the fifth decade of life with a male predominance, and triggering previous trauma or surgery history is present in 14% and 11% of all cases, respectively. 5 The most frequently reported location of CG is frontal sinuses.…”

“…Mucoceles show low- and high-signal intensities on T1- and T2-weighted images, but signal characteristics may vary depending on their fluid contents. 4 Meningoceles are easily diagnosed by MRI with its respective hypo- and hyperintense characteristics on T1- and T2-weighted images and presence of demonstrable bone defects. Importantly, presence of bone erosion mandates the exclusion of malignant causes.…”

Case report: Cholesterol granuloma of femur

“…Multiple parts of the body might appear, and the systemic incidence rate was 1/300,000–1/200,000, of which temporal bone was the most common ( 2 ). According to some sporadic reports, CG could be formed in various parts, such as thyroid ( 3 ), lung ( 4 ), breast ( 5 ), mediastinum ( 6 ), testis ( 7 ), pancreas ( 8 ), eyes ( 9 ), kidney ( 10 ), peritoneum ( 11 ), lymph nodes ( 12 ), petrous apex ( 13 ) and facial bones ( 14 ).…”

First Case Report of Cholesterol Granuloma of Femur

“…Multiple parts of the body might appear, and the systemic incidence rate was 1/300,000-1/200,000, of which temporal bone was the most common [2]. According to reports, CG could be formed in various parts of the human body, such as thyroid [3], lung [4], breast [5], mediastinum [6], testis [7], pancreas [8], eyes [9], kidney [10], peritoneum [11], lymph nodes [12], facial bones [13] and temporal bones [14].…”