Cholesterol in Nanobiotechnology

Schattling, Philipp; Zhang, Yan; Teo, Boon Mian; Städler, Brigitte

doi:10.1002/3527600906.mcb.201500007

Cited by 2 publications

(1 citation statement)

References 242 publications

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“…synthesized a lipophilic photoresponsive NO donor, Ru nitrosyl complex [Ru(L)Cl(NO)] (L = N , N ′‐ethylene‐bis(4‐cholesteryl‐hemisuccinate‐salicylideneamine)), and attached the newly developed NO donor to the bilayer of 1,2‐ditetradecanoyl‐ sn ‐glycero‐3‐phospho‐(1′‐rac‐glycerol) liposomes, leading to the design of photoinduced NO‐releasing liposomes ( Figure a) . Cholesterol anchoring into liposomes has been shown to be superior over a covalent linkage or electrostatic interaction, and in this study cholesterol groups facilitated an effective linking affinity of the NO donors to the liposomes. Upon Xe irradiation, the liposomes released 2.3 × 10 −6 m of NO, which is at a relevant concentration for anticancer activity.…”

Section: No Delivery From Injectable Materialsmentioning

confidence: 99%

Progress and Promise of Nitric Oxide‐Releasing Platforms

2018

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Nitric oxide (NO) is a highly potent radical with a wide spectrum of physiological activities. Depending on the concentration, it can enhance endothelial cell proliferation in a growth factor‐free medium, mediate angiogenesis, accelerate wound healing, but may also lead to tumor progression or induce inflammation. Due to its multifaceted role, NO must be administered at a right dose and at the specific site. Many efforts have focused on developing NO‐releasing biomaterials; however, NO short half‐life in human tissues only allows this molecule to diffuse over short distances, and significant challenges remain before the full potential of NO can be realized. Here, an overview of platforms that are engineered to release NO via catalytic or noncatalytic approaches is presented, with a specific emphasis on progress reported in the past five years. A number of NO donors, natural enzymes, and enzyme mimics are highlighted, and recent promising developments of NO‐releasing scaffolds, particles, and films are presented. In particular, key parameters of NO delivery are discussed: 1) NO payload, 2) maximum NO flux, 3) NO release half‐life, 4) time required to reach maximum flux, and 5) duration of NO release. Advantages and drawbacks are reviewed, and possible further developments are suggested.

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Section: No Delivery From Injectable Materialsmentioning

confidence: 99%

Progress and Promise of Nitric Oxide‐Releasing Platforms

2018

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Mucopenetrating micelles with a PEG corona

et al. 2017

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Crossing the intestinal mucus layer is a long-standing challenge for orally delivered nanoparticles carrying therapeutic cargo. We report the assembly of mucopenetrating cargo-loaded micelles using block copolymers consisting of either linear poly(ethylene glycol) (PEG) or bottle-brush poly(oligo(ethylene glycol)methacrylate) (PEG) as the hydrophilic block and poly(caprolactone) (PCL) or poly(cholesteryl methacrylate) (PCMA) as the hydrophobic extension. The micelles were shown to preserve their stability and retain ∼50% of their cargo in simulated gastric fluid. The ability of micelles to diffuse through reconstituted porcine mucus was assessed in a microfluidic set-up. Finally, the delivery of Nile Red as a hydrophobic model cargo across a mucus layer produced by epithelial cells was demonstrated. These engineered mucopenetrating micelles have potential to be developed into efficient absorption enhancers, contributing a nanotechnology solution to oral drug delivery.

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Cholesterol in Nanobiotechnology

Cited by 2 publications

References 242 publications

Progress and Promise of Nitric Oxide‐Releasing Platforms

Progress and Promise of Nitric Oxide‐Releasing Platforms

Mucopenetrating micelles with a PEG corona

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