Cholesterol inhibits assembly and activation of the EphA2 receptor
Ryan J Schuck,
Alyssa E Ward,
Amita R Sahoo
et al.
Abstract:The receptor tyrosine kinase EphA2 drives cancer malignancy by facilitating metastasis. EphA2 can be found in different self-assembly states: as a monomer, dimer, and oligomer. However, our understanding remains limited regarding which EphA2 state is responsible for driving pro-metastatic signaling. To address this limitation, we have developed SiMPull-POP, a single-molecule method for accurate quantification of membrane protein self-assembly. Our experiments revealed that a reduction of plasma membrane choles… Show more
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