Cholesterol modulates the pressure response of DMPC membranes

Predicting asymmetric phospholipid microstructures in solutions

“…18 Another research direction is to explore the mechanical properties, such as local pressure and interfacial permeability, of symmetric phospholipid membranes via experimentations and simulations. [21][22][23][24][25] A previous experiment revealed the pressure response of cholesterol to solid-loaded phospholipid multilayers; it proved that cholesterol at a certain concentration decreases the tendency of separation and presents a new path for the construction of stable model membranes. 21 Meanwhile, a theoretical approach based on self-consistent eld theory has been developed to obtain the local stress across the membranes and interfaces in so matter; this approach predicts the membrane lateral stress prole in the regions of the head and tail and the stress between hydrophobic and hydrophilic interfaces.…”