Cholesterol overload impairing cerebellar function: The promise of natural products

El‐Sayyad, Hassan I.

doi:10.1016/j.nut.2014.10.017

Cited by 23 publications

(13 citation statements)

References 138 publications

(135 reference statements)

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“…It has been shown that reducing the binding affinity of a serotonin 5-HT1A receptor agonist, altering G-protein coupling of the receptor and decreasing activity of the 5-hydroxytryptamine transporter occurred as a result of decreasing the cholesterol content of cell membranes experimentally 46,47. In this way, low levels of serum cholesterol metabolism may directly influence the levels of brain lipids and the cell membrane fluidity, which in turn affect serotonergic neurotransmission 48,49. Post-stroke depression may have similar pathophysiological processes.…”

Section: Discussionmentioning

confidence: 99%

<p>Serum lipid profiles and post-stroke depression in acute ischemic stroke patients</p>

Hui-ping¹,

Tu²,

Luan³

et al. 2019

NDT

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Purpose: Post-stroke depression (PSD) is a psychiatric complication after stroke that leads to poorer stroke outcomes. Recent observational studies have indicated that lipid profiles were associated with a higher risk of stroke and depression. This study aims to further explore the possible relationship between serum lipid profiles and the development of PSD. Methods: A total of 373 acute ischemic stroke patients were examined. Serum lipid profiles including high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), total cholesterol (TC), apolipoprotein A1 (Apo A1) and apolipoprotein B (Apo B) were measured within 24 hrs of admission. Depression symptoms were assessed by the 17-item Hamilton Depression Scale (HAMD-17) at the one-month follow-up, and HAMD scores ≥7 indicated a diagnosis of PSD. Results: A total of 114 patients were diagnosed with PSD at the one-month follow-up, for a percentage of 30.6%. There were significant differences in HDL-C levels ( P <0.001), LDL-C levels ( P =0.002) and the LDL/HDL ratio ( P <0.001) between the PSD and non-PSD groups, but no differences were observed in TGs, TC, Apo A1 or Apo B. Low serum HDL-C levels (r = −0.157, P <0.001) and elevated LDL-C levels (r =0.139, P =0.002) and the LDL/HDL ratio (r =0.227, P <0.001) were associated with HAMD scores. After adjusting for the NIHSS score, BI score, mRS score and alcohol consumption in the logistic analysis, low HDL-C levels and the highest quartile (≥3.07) of the LDL/HDL ratio were independently associated with the development of PSD (OR =0.250, 95% CI, 0.077–0.813, P =0.021 and OR =1.874, 95% CI, 1.050–3.347, P =0.034, respectively). Conclusion: Decreased levels of HDL-C and elevated levels of LDL/HDL ratio are associated with PSD. HDL-C and the LDL/HDL ratio are independent predictors of PSD.

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Section: Discussionmentioning

confidence: 99%

<p>Serum lipid profiles and post-stroke depression in acute ischemic stroke patients</p>

Hui-ping¹,

Tu²,

Luan³

et al. 2019

NDT

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“…There is a large amount of research that assigns them very important functions for the human organism [2]. These components possess antimicrobial and anti-inflammatory properties [3], can act as antioxidants [4], anticancer agents [5], antihepatotoxic agents [6] and can improve cardiovascular [7], oral [8] and skin health [9].…”

Section: Introductionmentioning

confidence: 99%

Investigation of Anthocyanins Stability from Pomegranate Juice (Punica Granatum L. Cv Ermioni) under a Simulated Digestion Process

et al. 2019

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Background: Pomegranate gained a widespread popularity as a functional food due to the high content of bioactive components of the whole fruit, as well as its juice and extracts. There is a large amount of research that assigns them very important functions for the human organism. Methods: The anthocyanins (ACNs) of pomegranate juice (PJ) from the Ermioni variety are quantitatively identified and their stability under a simulated digestion process (SDP) is investigated. ACNs, as well as phenolic compounds, were isolated through solid phase extraction and determined using high-performance liquid chromatography in every stage of the SDP. Total phenolics, total monomeric ACNs, polymeric color and antioxidant activity were also determined in pomegranate juice and during the digestion process. Results: The predominant anthocyanin was Cy-3-glucoside followed by the corresponding 3,5-diglucoside, which accounted for 40.8% and 27.4% of the total ACN content, respectively. About 65% of the total monomeric ACN content remained intact by the end of the simulated digestion process. Conclusions: The PJ of the Ermioni variety seems to retain a large amount of the bioactive compounds after the SDP. The antioxidant activity and total phenolic content (TPC) remain almost stable during the SDP, suggesting that the products formed during ACN degradation maintain the antioxidant activity of the parent molecule.

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“…Moreover, several plant isoprenoids have been reported to have antinflammatory properties and could represent an attractive therapeutic opportunity thanks to their commercial availability, low cost, oral bioavailability and low toxicity. Moreover, recent literature data have showed that these natural products can also regulate in central nervous system, in particular, controlling motor and cognitive function [91].…”

Section: Future Directionsmentioning

confidence: 99%

Mevalonate kinase deficiency: therapeutic targets, treatments, and outcomes

Marcuzzi

Piscianz

Brumatti

et al. 2017

Expert Opinion on Orphan Drugs

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Introduction: Mevalonate Kinase Deficiency (MKD) is a rare inborn disease caused by the mutation of mevalonate kinase gene. The clinical phenotype encompasses recurrent fever episodes in combination with gastrointestinal,\ud immunological, rheumatological and neurological complaints. No specific treatment is available, apart from the newly approved biologics (canakinumab), but MKD can be still considered an orphan-drug disease, since the identification of a reliable therapeutic target needs an improved knowledge on the pathogenesis of the disease, which is so far controversial.\ud Areas covered: On one hand, shortage of isoprenoid compounds downstream of mevalonate led to a defective geranylgeranylation of RhoA/Rac proteins and increased caspase-1-dependent inflammation. On the other hand, recent studies pointed the attention to the pathogenic role of the mitochondrial dysfunction and to defective production of 25-hydroxycholesterol. These mechanisms are not exclusive of each other, as they can contribute to different pathogenic features of MKD.\ud Expert opinion: Innovative therapeutic approaches to MKD may count upon various medicaments, such as isoprenoid compounds that can enter the metabolic pathway, specific enzyme inhibitors and mitochondria-\ud targeted drugs. Some of these compounds have already passed the clinical phase for other uses and may be repositioned to the treatment of MKD, fostering the development of clinical trials

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Cholesterol overload impairing cerebellar function: The promise of natural products

Cited by 23 publications

References 138 publications

<p>Serum lipid profiles and post-stroke depression in acute ischemic stroke patients</p>

<p>Serum lipid profiles and post-stroke depression in acute ischemic stroke patients</p>

Investigation of Anthocyanins Stability from Pomegranate Juice (Punica Granatum L. Cv Ermioni) under a Simulated Digestion Process

Mevalonate kinase deficiency: therapeutic targets, treatments, and outcomes

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