Cholesterol reducing and bile-acid binding properties of taioba (Xanthosoma sagittifolium) leaf in rats fed a high-fat diet

Jackix, Elisa de Almeida; Monteiro, Elisa Bernardes; Raposo, Helena Fonseca; Amaya-Farfán, Jaime

doi:10.1016/j.foodres.2013.02.017

Cited by 24 publications

(10 citation statements)

References 29 publications

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“…Moreover, quercetin, an abundant flavonoid in date seed, was found to profoundly decrease the activity and mRNA levels of various hepatic lipogenic enzymes (Odbayar et al ., 2006). The cholesterol‐lowering effect of date seed may be through increasing bile acid excretion, as demonstrated by other plant extracts (de Almeida Jackix et al ., 2013). Phenolic compounds in date seeds were indicated to inhibit pancreatic lipase activity and thus reduce the absorption of dietary lipids (Martinez‐Gonzalez et al ., 2017).…”

Section: Discussionmentioning

confidence: 99%

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The effect of date seed powder supplementation on glycaemic markers and lipid profile in women with overweight and obesity: a randomised controlled trial

Hashemzadeh

Shojaei‐Zarghani

Miri

et al. 2023

Int J of Food Sci Tech

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Objective: The aim of this randomized controlled trial (RCT) was to investigate the effect of date kernel on glycemic control, lipid pro le, and weight in women with overweight and obesity.Design: One hundred twenty-four women with overweight or obesity were randomly assigned to receive the date kernel supplement or placebo for 12 weeks. Serum HbA1c was measured by High-performance liquid chromatography (HPLC), and fasting plasma glucose and lipid pro les by enzyme-linked immunosorbent assay (ELISA) kits. The participants' dietary intake and physical activity were recorded at baseline. Results: A total of 98 subjects aged 40.7 years completed the trial (48 in the date kernel group, and 50 in the placebo group). From baseline to 12 weeks, date kernel supplementation resulted in a signi cant decrease in HbA1c [mean (SD): -0.45 (0.36)] and FPG compared to the placebo [-0.16 (0.27)] (p <0.001). No signi cant change was observed in the lipid pro les of the total participants. However, date kernel consumption decreased cholesterol and TG in hypercholesterolemic and hypotriglyceridemic participants compared to the placebo. Conclusion: Overall, 12 weeks of date kernel supplements in overweight or obese women resulted in an improvement in glycemic markers compared with the placebo. In terms of lipid pro le, a signi cant reduction in total cholesterol and TG were observed only in hyperlipidemic subjects.Study was registered in IRCT.ir under IRCT20211217053429N1.

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Section: Discussionmentioning

confidence: 99%

“…Date seed compounds may act on enzymes involved in TG (Wu et al ., 2019) and cholesterol synthesis (de Almeida Jackix et al ., 2013), and lipoprotein and hepatic lipases (Duraipandiyan et al ., 2016). Date seed polysaccharides indicated functional properties and prebiotic potential (Noorbakhsh & Khorasgani, 2022).…”

Section: Discussionmentioning

confidence: 99%

The effect of date seed powder supplementation on glycaemic markers and lipid profile in women with overweight and obesity: a randomised controlled trial

Hashemzadeh

Shojaei‐Zarghani

Miri

et al. 2023

Int J of Food Sci Tech

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“…The polysaccharide bound with bile acid and brought it out through defecation (Panith et al, 2016). Bile acid binding capability of polysaccharide ensures the cholesterol level decreased in an animal laboratory experiment (de Almeida et al, 2013). Polysaccharide also is considered as not toxic as this primary metabolite cannot be absorbed by the intestine.…”

Section: Discussionmentioning

confidence: 99%

Bioassay Guided Isolation of Polysaccharide Rich Fraction from Myrmecodia Platytyrae and its Bile Acid Binder Property

Hasan¹,

Wahab²,

Mizaton³

et al. 2019

Malays. j. med. biol. res.

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Bioassay guided isolation was done on the Myrmecodia platytyrae (MyP) extracts in order to find the best extract that can bind with bile acid. The function of bile acid binder is to reduce the reabsorption of bile acid in the intestine so that it will cause the decrease of cholesterol in the blood circulation. The extraction process was started by using different organic solvent such as hexane, toluene, ethyl acetate, ethanol and water. All extracts were tested its bile acid binding properties and the extract gave out highest activity was selected to be fractionated. The result showed that water extract has highest bile acid binding property (75%). Then, fractionation process was performed in order to find the best fraction from water extract that have bile acid binding property. The sub-fractionation processes were continued and the process only focussed to the fraction that has highest bile acid binding property until a white powder with 97.02 % carbohydrate was obtained. The powder was subjected to FTIR and was found to have glycosidic bond as shown by bands at 1141 until 1018 cm -1 which is a character of polysaccharide. The polysaccharide rich fraction was hydrolysed and subjected to HPLC to identify its monosaccharide groups. The result showed the presence of glucose and fructose were found to be among the major monosaccharides. This result suggested that the polysaccharide from MyP water extract with high bile acid binding property was gluco-fructan.

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“…Para determinação da composição centesimal foram utilizadas tanto a folha crua como a cozida. Quanto ao cozimento, foram utilizadas 100g de folha em 1 litro de água potável a 100ºC, durante 10 minutos, sendo este processo repetido sempre que necessário (JacKiX et al, 2013). As folhas cozidas foram filtradas em papel de filtro e o extrato obtido da filtração foi utilizado para análise fitoquímica.…”

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Potencial hipocolesterolêmico e antioxidante da folha de Taioba (Xanthosoma sagittifolium (L.) Schott ) em camundongos dislipidêmicos induzidos por dieta

Souza,

Duarte,

Lima

et al. 2024

NUTRIVISA

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A taioba (Xanthosoma sagittifolium (L.) Schott) é uma planta alimentícia não convencional cultivada tanto para fins alimentícios como medicinais. Portanto, este estudo objetivou avaliar o efeito hipocolesterolêmico e antioxidante da folha de taioba em camundongos dislipidêmicos induzido por dieta. Os camundongos Swiss foram alimentados por 90 dias com dieta hipercolesterolêmica e após 30 dias de tratamento (gavagem) com 500mg/kg de taioba, verificou-se resultado semelhante ao tratamento com 20mg/kg da droga padrão (sinvastatina), reduzindo significativamente o colesterol total, LDL-c, colesterol não HDL, triglicerídeos e o risco cardiovascular, medido pelo índice Castelli I. Além disso, a taioba mostrou-se superior à sinvastatina, pois apresentou ainda atividade hipoglicemiante, antioxidante e nefroprotetora.

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Cholesterol reducing and bile-acid binding properties of taioba (Xanthosoma sagittifolium) leaf in rats fed a high-fat diet

Cited by 24 publications

References 29 publications

The effect of date seed powder supplementation on glycaemic markers and lipid profile in women with overweight and obesity: a randomised controlled trial

The effect of date seed powder supplementation on glycaemic markers and lipid profile in women with overweight and obesity: a randomised controlled trial

Bioassay Guided Isolation of Polysaccharide Rich Fraction from Myrmecodia Platytyrae and its Bile Acid Binder Property

Potencial hipocolesterolêmico e antioxidante da folha de Taioba (Xanthosoma sagittifolium (L.) Schott ) em camundongos dislipidêmicos induzidos por dieta

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