A positive family history of coronary heart disease alone confers an increased risk, which may be affected by untreated hypercholesterolemia. Dietary counseling is a first-line treatment approach. To determine whether nurse counseling can provide additional benefits over usual physician efforts to lower dietary fat in high-risk persons, 117 apparently healthy adult siblings of persons with premature coronary heart disease were counseled by a registered nurse using adapted national guidelines. Reductions in total fat, saturated fat, and cholesterol were significantly greater in the nurse group compared to those in the usual care group. Total fat intake decreased by 14 g in the nurse group, compared with an increase of 5 g in the usual care group (p=0.0001). Assignment to the nurse group was also a significant predictor of a greater reduction in the percentage of total fat calories (p=0. H ealthy brothers and sisters of individuals with premature coronary heart disease (CHD) are at a markedly increased risk for developing premature CHD themselves. 1 Clustering of highly prevalent and modifiable CHD risk factors has also been shown in these brothers and sisters, 2-3 as have unhealthy eating behaviors. 4 The National Cholesterol Education Program Adult Treatment Panel II (ATP II) guidelines 5 recommend dietary intervention as the first-line approach in the treatment of hypercholesterolemia. The new ATP III guidelines will probably again place emphasis on the use of dietary interventions as an adjunct to pharmacologic treatment. Physicians are encouraged to provide initial dietary counseling. The guidelines suggest that registered dietitians and qualified nutritionists serve as consultants if initial attempts by primary care providers to alter diet are unsuccessful. The relative effectiveness of dietary counseling by dietitians, nurses, and physicians remains unclear. [6][7][8][9] Studies have demonstrated that only a minority of hypercholesterolemic patients are referred to dietitians by physicians and that most physicians are unable to provide intensive dietary counseling themselves. [10][11][12][13] Given that the number of available dietitians is small relative to that of nurses, and that physicians alone may not be able to concentrate on dietary counseling in clinical encounters, the purpose of this study was to determine whether a registered nurse, trained in dietary intervention, could effectively counsel high-risk individuals to lower their total fat and cholesterol intake. This is important both because of the primary impact of diet and because of the role diet may play in augmenting the efficacy of the statin drugs. In an era when drugs are being increasingly used, effective ways to implement dietary intervention remain important. Thus, we compared nurse counseling with usual care by a physician in healthy, free-living brothers and sisters of persons with premature CHD. This was part of a larger prospective study of coronary disease risk factors in persons with familial-aggregated premature CHD. From 1991Fr...