Cholesterol Response in Inbred Strains of Rats, Rattus norvegicus

Zutphen, L.F.M. van; Bieman, M. G. C. W. den

doi:10.1093/jn/111.10.1833

Cited by 30 publications

(12 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This substantiates earlier reports (Van Zutphen and Fox, 1977;Van Zutphen and Den Bieman, 1981) which suggest that plasma esterase patterns predict the susceptibility to dietary cholesterol. However, the results obtained with the Wistar rats are not completely in line with those found in the inbred strains.…”

Section: Discussionsupporting

confidence: 92%

“…An anodal fast moving zone, Es-1 esterase (Van Zutphen, 1983) was clearly present in the SHR/Cpb strain, whereas in the SD/Cpb strain this zone was absent or stained only very faintly. This difference in zymotype between these rat strains has been reported earlier (Van Zutphen and Den Bieman, 1981). The presence or absence of the Es-1 esterase often predicts the serum cholesterol response to dietary cholesterol in inbred rat and rabbit strains.…”

Section: Experiments With Humanssupporting

confidence: 80%

“…The presence or absence of the Es-1 esterase often predicts the serum cholesterol response to dietary cholesterol in inbred rat and rabbit strains. The cholesterolemic response was low in 6 out of 7 inbred rat strains displaying the Es-1 zone, whereas absence of the enzyme was associated with the development of high degrees of hypercholesterolemia after cholesterol feeding in 2 out of 3 inbred rat strains (Van Zutphen and Den Bieman, 1981). Similar results were obtained in a study with six inbred strains of rabbits (Van Zutphen and Fox, 1977) where the cholesterolemic response to dietary cholesterol correlated with the Est-2 genotype.…”

Section: Experiments With Humanssupporting

confidence: 78%

“…The esterase pattern after gel electrophoresis (Van Zutphen and Fox, 1977;Van Zutphen and Den Bieman, 1981) only gives qualitative information. Therefore, the present study was carried out in an attempt to correlate absolute levels of plasma total :[:Correspondence to be addressed to: Dr. A. C. Beynen, Department of Laboratory Animal Science, State University, Yalelaan 1, 3508 TD Utrecht, The Netherlands.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Arylesterase activities in the plasma of rats, rabbits and humans on low- and high-cholesterol diets

Beynen

Weinans

Katan

1984

Comparative Biochemistry and Physiology Part B: Comparative Bio

View full text Add to dashboard Cite

Abstract--1. Arylesterase activities were measured with fl-naphthylpropionate and/or ~-naphthylacetate as substrate in the plasma of rats, rabbits and humans on low-and high-cholesterol diets.2. The plasma esterase activities measured with ~-naphthylacetate were similar in rats, rabbits and humans. With fl-naphthylpropionate as a substrate, rabbits were found to have a markedly higher esterase activity than rats and humans.3. Basal plasma esterase activity was significantly higher in an inbred rat strain which is hyporesponsive to dietary cholesterol than in a hyperresponsive strain.4. In rats, but not in humans and rabbits, plasma esterase activity was significantly increased by a high-cholesterol diet.5. In individual humans and random-bred rabbits and rats there was no association between initial plasma total esterase activity and the subsequent plasma cholesterol response to cholesterol feeding.6. We suggest that arylesterases are associated with cholesterol metabolism and with the response to dietary cholesterol in rats; evidence for such a role in rabbits and humans is, however, inconclusive.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Experiments With Humanssupporting

confidence: 80%

Section: Experiments With Humanssupporting

confidence: 78%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Arylesterase activities in the plasma of rats, rabbits and humans on low- and high-cholesterol diets

Beynen

Weinans

Katan

1984

Comparative Biochemistry and Physiology Part B: Comparative Bio

View full text Add to dashboard Cite

show abstract

“…The differences in Ch absorption efficiency among strains or individuals have been observed in animals (26)(27)(28)(43)(44)(45)(46)(47)(48)(49) and humans (50)(51)(52)(53). Recent studies (26)(27)(28) suggest that such variability could result from the interaction of multiple genes in the enterocyte.…”

Section: Discussionmentioning

confidence: 99%

Cholesterol absorption is mainly regulated by the jejunal and ileal ATP-binding cassette sterol efflux transporters Abcg5 and Abcg8 in mice

Duan

Wang

2004

Journal of Lipid Research

View full text Add to dashboard Cite

In the present study, we investigated whether intestinal sterol efflux transporters Abcg5 and Abcg8 play a major role in determining variations in cholesterol (Ch) absorption efficiency, and we compared the physiological functions of the duodenal, jejunal, and ileal Abcg5 and Abcg8 on the absorption of Ch and sitostanol in inbred mice challenged with various amounts of Ch, sitostanol, hydrophilic, or hydrophobic bile acids. We found that Abcg5 and Abcg8 in the jejunum and ileum, but not in the duodenum, were main factors in determining, in part, variations in Ch absorption efficiency. The jejunal and ileal Abcg5 and The small intestine is a unique organ that provides dietary and reabsorbed biliary cholesterol (Ch) to the body and plays a critical role in the regulation of whole-body Ch balance (1, 2). Because elevated plasma Ch concentrations are important risk factors for cardiovascular diseases, intensive studies have been carried out to search for physical-chemical, biochemical, and genetic determinants of intestinal Ch absorption. Recently, two independent groups (3, 4) used a microarray analysis of mouse intestine and liver genes upregulated by a liver X receptor (LXR) agonist, as well as a positional cloning approach to identify mutations in sitosterolemia patients in either member of an adjacent pair of genes, ABCG5 and ABCG8 , encoding ATP-binding cassette (ABC) transporters expressed in the liver and intestine. By studying their function and expression in some "manufactured" mouse strains treated with or without LXR agonists (5-9), it has been proposed that ABCG5 and ABCG8 could promote efflux of Ch and sitosterol (plant sterol) from the enterocyte back into the intestinal lumen for elimination and mediate biliary sterol secretion in the human. Although a very large number of polymorphic variants in both Abcg5 and Abcg8 among 20 strains of inbred mice have been identified (10), none of these mice showed any detectable levels of plasma sitosterol under chow diet (containing ‫ف‬ 0.01% sitosterol) conditions. Thus, whether the polymorphisms at the Abcg5 and Abcg8 genes and their expression levels in the intestine are an important determinant of intestinal Ch absorption efficiency in healthy inbred mice remains to be investigated. Furthermore, the autosomal recessive disorder sitosterolemia (11-13) is mainly characterized by hyperabsorption of Ch and sitosterol, and reduced secretion of these sterols into bile. In patients with sitosterolemia (14-17), the intestinal absorp-

show abstract

Gene-environment Interaction: Variability Gene Concept

Berg

1994

Genetic Factors in Coronary Heart Disease

View full text Add to dashboard Cite

Cholesterol Response in Inbred Strains of Rats, Rattus norvegicus

Cited by 30 publications

References 15 publications

Arylesterase activities in the plasma of rats, rabbits and humans on low- and high-cholesterol diets

Arylesterase activities in the plasma of rats, rabbits and humans on low- and high-cholesterol diets

Cholesterol absorption is mainly regulated by the jejunal and ileal ATP-binding cassette sterol efflux transporters Abcg5 and Abcg8 in mice

Gene-environment Interaction: Variability Gene Concept

Contact Info

Product

Resources

About