Cholesterol-rich low density lipoproteins are also more oxidized

Ланкин, В. З.; Viigimaa, Margus; Tikhaze, A. K.; Kumskova, E. M.; Konovalova, G. G.; Abina, Jelena; Zemtsovskaya, Galina; Коткина, Т. И.; Yanushevskaya, E. V.; Власик, Т. Н.

doi:10.1007/s11010-011-0853-y

Cited by 17 publications

(8 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These associations are stronger for the newly introduced oxLDL/NOx ratio. As well, the oxLDL/NOx ratio is strongly correlated with the atherogenic index and more importantly, with the oxLDL/HDL-C ratio, the best lipid biomarker used for discriminating between coronary artery disease patients and healthy control subjects, and also the best blood biomarker that reflects atherosclerotic disease activity in the arterial wall (Huang et al, 2008;Lankin et al, 2011) Our results are in accordance with literature with regard to the damaging effects of hyperlipidemia, mediated or stimulated by oxidative stress. Numerous studies have supported the role of hyperlipidemia in atherosclerosis, endothelial dysfunction and progression of coronary heart diseases (Wallace et al, 2010;Deanfield et al, 2007;Highashino et al, 2010;Van den Oever et al, 2010).…”

Section: Discussionsupporting

confidence: 91%

Oxidized LDL and NO Synthesis as Biomarkers of Atherogenesis - Correlations with Metabolic Profile in Elderly

Borșa¹,

Ionescu²,

Grădinaru³

2012

Atherogenesis

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 91%

Oxidized LDL and NO Synthesis as Biomarkers of Atherogenesis - Correlations with Metabolic Profile in Elderly

Borșa¹,

Ionescu²,

Grădinaru³

2012

Atherogenesis

View full text Add to dashboard Cite

“…Ratios of Ox-LDL/HDL are also positively correlated with plasma CRP, ICAM-1, and VCAM-1 levels (Supplementary table 2). Recently, Ox-LDL/HDL has been recognized as the most useful and independent biochemical marker for atherosclerosis (Lankin et al, 2011). Therefore, increased Ox-LDL/HDL ratios with the increasing levels of arsenic exposure and their correlations with other inflammatory and adhesion molecules observed in this study may provide important clues to developing future CVD in individuals living in arsenic-endemic areas.…”

mentioning

confidence: 54%

Increases in Oxidized Low-Density Lipoprotein and Other Inflammatory and Adhesion Molecules With a Concomitant Decrease in High-Density Lipoprotein in the Individuals Exposed to Arsenic in Bangladesh

Karim

Rahman

Islam

et al. 2013

Toxicological Sciences

View full text Add to dashboard Cite

Elevated exposure to arsenic has been suggested to be associated with atherosclerosis leading to cardiovascular disease (CVD). However, biochemical events underlying the arsenic-induced atherosclerosis have not yet been fully documented. The aim of this study was to investigate the associations of circulating molecules involved in atherosclerosis with arsenic exposure in the individuals exposed to arsenic in Bangladesh. A total of 324 study subjects, 218 from arsenic-endemic areas and 106 from nonendemic areas in Bangladesh, were recruited. Drinking water, hair, nail, and blood samples were collected from the study subjects for analysis. Total cholesterol (TC), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) levels were lower in arsenic-endemic subjects than those of nonendemic subjects. Oxidized LDL (Ox-LDL), C-reactive protein (CRP), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) levels were significantly higher in arsenic-endemic subjects than those in nonendemic subjects. All these circulating molecules showed significant correlations with arsenic exposure (water, hair, and nail arsenic concentrations), and all these relations were significant before and after adjusting for relevant covariates. Among the circulating molecules tested in this study, HDL, Ox-LDL, and CRP showed dose-response relationships with arsenic exposure. Ox-LDL/HDL ratios were increased with the increasing concentrations of arsenic in the water, hair, and nails. Furthermore, non-HDL cholesterol and TC/HDL ratios were significantly correlated with arsenic exposure before and after adjusting for relevant covariates. Thus, all the observed associations may be the major features of arsenic exposure-related atherosclerosis leading to CVD.

show abstract

“…Other studies have shown an association between oxLDL and HbA1c [ 17 ], but in the present study univariate analysis showed that the oxLDL/HDL and oxLDL/LDL ratios correlated significantly with HbA1c, while oxLDL itself correlated only weakly with HbA1c (p = 0.062). We examined the ratios of oxLDL/HDL and oxLDL/LDL as previous reports suggest that these metrics may be more informative than oxLDL alone [ 31 – 33 ]. In a similar study of T2DM, oxLDL/HDL and oxLDL/LDL, but not oxLDL alone, were associated with atherosclerosis, even when adjusting for BMI, gender, age and hypolipidemic treatment [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Associations of Circulating Oxidized LDL and Conventional Biomarkers of Cardiovascular Disease in a Cross-Sectional Study of the Navajo Population

et al. 2016

View full text Add to dashboard Cite

The prevalences of cardiovascular disease (CVD) and type 2 diabetes (T2D) have increased among the Navajo Native American community in recent decades. Oxidized low-density lipoprotein (oxLDL) is a novel CVD biomarker that has never been assessed in the Navajo population. We examined the relationship of oxLDL to conventional CVD and T2D risk factors and biomarkers in a cross-sectional population of Navajo participants. This cross-sectional study included 252 participants from 20 Navajo communities from the Diné Network for Environmental Health Project. Plasma samples were tested for oxLDL levels by a sandwich enzyme-linked immunosorbent assay. Univariate and multivariate analyses were used to determine the relationship of oxLDL and oxidized- to non-oxidized lipoprotein ratios to glycated hemoglobin (HbA1c), C-reactive protein (CRP), interleukin 6 (IL6) and demographic and health variables. Type 2 diabetes, hypertension and obesity are very prevalent in this Navajo population. HbA1c, CRP, body mass index (BMI), high-density lipoprotein, and triglycerides were at levels that may increase risk for CVD and T2D. Median oxLDL level was 47 (36.8–57) U/L. Correlational analysis showed that although oxLDL alone was not associated with HbA1c, oxLDL/HDL, oxLDL/LDL and CRP were significantly associated with HbA1c and glucose. OxLDL, oxLDL/HDL and oxLDL/LDL were significantly associated with CRP. Multivariate analysis showed that triglycerides were a common and strong predictor of oxLDL, oxLDL/HDL and oxLDL/LDL. OxLDL was trended with HbA1c and glucose but did not reach significance, however, HbA1c was an independent predictor of OxLDL/HDL. CRP trended with oxLDL/HDL and was a weak predictor of oxLDL/LDL. This Navajo subset appears to have oxLDL levels comparable to subjects without evidence of CVD reported in other studies. The high prevalence of T2D, hypertension and obesity along with abnormal levels of other biomarkers including HbA1c indicate that the Navajo population has a worsening CVD risk profile.

show abstract

Cholesterol-rich low density lipoproteins are also more oxidized

Cited by 17 publications

References 23 publications

Oxidized LDL and NO Synthesis as Biomarkers of Atherogenesis - Correlations with Metabolic Profile in Elderly

Oxidized LDL and NO Synthesis as Biomarkers of Atherogenesis - Correlations with Metabolic Profile in Elderly

Increases in Oxidized Low-Density Lipoprotein and Other Inflammatory and Adhesion Molecules With a Concomitant Decrease in High-Density Lipoprotein in the Individuals Exposed to Arsenic in Bangladesh

Associations of Circulating Oxidized LDL and Conventional Biomarkers of Cardiovascular Disease in a Cross-Sectional Study of the Navajo Population

Contact Info

Product

Resources

About