Cholesteryl ester transfer protein and atherosclerosis in Japanese subjects: a study based on coronary angiography

Goto, Akitomo; Sasai, Kanna; Suzuki, Satoshi; Fukutomi, Tatsuya; Ito, Shigenori; Matsushita, Toyoaki; Okamoto, Mitsuhiro; Suzuki, Takahiko; Itoh, Makoto; Okumura-Noji, Kuniko; Yokoyama, Shinji

doi:10.1016/s0021-9150(01)00476-2

Cited by 42 publications

(35 citation statements)

References 60 publications

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“…In the Korean population, the B1B1 homozygote of the CETP TaqIB polymorphism is associated with low HDL-C levels in females and non-smoking males, and may be an independent genetic risk factor of CAD (Park et al, 2003). It was also reported that the B2B2 genotype in CETP TaqIB polymorphism may act as a protective factor against atherosclerosis in Japanese ( Goto et al, 2001). The results of this study also agree with these previous reports in different racial populations.…”

Section: Discussionsupporting

confidence: 91%

Association between TaqIB polymorphism of cholesteryl ester transfer protein and coronary artery disease in the Chinese population

Liu

Song

et al. 2012

J. Zhejiang Univ. Sci. B

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Abstract:Objective: To assess whether the TaqIB polymorphism of cholesteryl ester transfer protein (CETP) is associated with coronary artery disease (CAD) in Chinese population, we performed a meta-analysis in this paper. Methods: We searched PubMed, Embase, the Science Citation Index (SCI), the China Biological Medicine database (CBM), the China National Knowledge Infrastructure (CNKI), and the Wanfang database for relevant articles. Data were extracted, and pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Results: The literature search yielded 448 studies, in which 10 case-control studies including 1 694 cases and 1 456 controls matched the selection criteria. The combined B1 and B2 allele frequencies were 0.587 and 0.413, respectively. The pooled OR was 1.10 (95% CI, 0.89-1.34) for comparing the B1B1 or B1B2 carriers with B2B2 carriers, and was 1.27 (95% CI, 1.09-1.49) in the B1B1 carriers versus B2B2 or B1B2 carriers. Conclusions: In the present study, the TaqIB polymorphism of CETP was found to be associated with CAD in the Chinese population.

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Section: Discussionsupporting

confidence: 91%

Association between TaqIB polymorphism of cholesteryl ester transfer protein and coronary artery disease in the Chinese population

Liu

Song

et al. 2012

J. Zhejiang Univ. Sci. B

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“…The associations of TaqIB with various parameters is generally thought to arise from strong linkage disequilibrium between TaqIB and the -C629A polymorphism, of which the latter has been shown to directly affect CETP promoter activity (46)(47)(48). Significant associations of the B1B1 genotype with higher plasma CETP concentration and/or CETP activity and lower HDL-c levels were found in several studies (43,45,(49)(50)(51), but this was not consistently observed (40,(52)(53)(54). Furthermore, it has been reported that the effects of TaqIB on the above parameters are gender-dependent and also influenced by alcohol use, body mass index, and insulin levels (40,43,49,(55)(56)(57).…”

Section: Cetp Gene Polymorphisms and Cardiovascular Riskmentioning

confidence: 99%

A review of CETP and its relation to atherosclerosis

Grooth

Klerkx

Stroes

et al. 2004

Journal of Lipid Research

235

150

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“…The less-common allele of this SNP has been shown to be associated with lower CETP and higher HDL levels across numerous studies and populations with highly significant P values (45,49,53,60,. Only in studies with small test populations has neither CETP nor HDL been affected in a statistically significant manner (43,(93)(94)(95)(96)(97)(98)(99)(100)(101)(102)(103)(104)(105)(106)(107). Since it is not immediately apparent how this SNP could modulate CETP expression, it has long been suspected that this SNP is linked with another change that more directly affects expression.…”

Section: Wild-type Proteinmentioning

confidence: 99%

Natural genetic variation as a tool in understanding the role of CETP in lipid levels and disease

Boekholdt

Thompson

2003

Journal of Lipid Research

153

117

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Since the identification of cholesteryl ester transfer protein (CETP), its role in the modulation of HDL levels and cardiovascular disease has been debated. With the early detection of genetic variants followed by the finding of families deficient in CETP, genetic studies have played a large role in the attempts to understand the association of CETP with lipids and disease; however, results of these studies have often led to disparate conclusions. With the availability of a greater variety of genetic polymorphisms and larger studies in which disease has been examined, it is now possible to compare the breadth of CETP genetic studies and draw better conclusions. The most broadly studied polymorphism is TaqIB for which over 10,000 individuals have been genotyped and had HDL levels determined. When these studies are subjected to a meta-analysis, the B2B2 homozygotes are found to have higher HDL levels than B1B1 homozygotes (0.12 mmol/l, 95% CI ‫؍‬ 0.11-0.13, P Ͻ 0.0001). A similar analysis of the I405V polymorphism yields 0.05 mmol/l higher HDL levels in 405VV homozygotes than in 405II homozygotes (95% CI ‫؍‬ 0.03-0.07, P Ͻ 0.0001). The implications of these studies for cardiovascular disease will be addressed. -Boekholdt, S. M., and J. F. Thompson. Natural genetic variation as a tool in understanding the role of CETP in lipid levels and disease. J. Lipid Res. 2003. 44: 1080-1093.

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Cholesteryl ester transfer protein and atherosclerosis in Japanese subjects: a study based on coronary angiography

Cited by 42 publications

References 60 publications

Association between TaqIB polymorphism of cholesteryl ester transfer protein and coronary artery disease in the Chinese population

Association between TaqIB polymorphism of cholesteryl ester transfer protein and coronary artery disease in the Chinese population

A review of CETP and its relation to atherosclerosis

Natural genetic variation as a tool in understanding the role of CETP in lipid levels and disease

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