2013
DOI: 10.1016/j.ijpharm.2013.06.056
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Cholic acid modified N-(2-hydroxy)-propyl-3-trimethylammonium chitosan chloride for superoxide dismutase delivery

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Cited by 30 publications
(19 citation statements)
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“…HTCC-CA was synthesized and purified as reported previously. 15 First, HTCC was synthesized by using chitosan (2 g) and GTMAC (5 mL). Second, HTCC-CA was synthesized by using purified HTCC (0.5 g) and CA (0.1, 0.2, or 0.5 g) with EDC and NHS as activator and coupled agent.…”
Section: ■ Introductionmentioning
confidence: 99%
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“…HTCC-CA was synthesized and purified as reported previously. 15 First, HTCC was synthesized by using chitosan (2 g) and GTMAC (5 mL). Second, HTCC-CA was synthesized by using purified HTCC (0.5 g) and CA (0.1, 0.2, or 0.5 g) with EDC and NHS as activator and coupled agent.…”
Section: ■ Introductionmentioning
confidence: 99%
“…16 The CA grafting degree of HTCC-CA was calculated according to the NMR spectra as reported previously. 15 Hydrophobic aggregation of the HTCC-CA samples in aqueous solutions was characterized using pyrene as a fluorescence probe as reported in the literature, 17 and hydrophobic surface of the aggregates was characterized using ANS as a fluorescence probe. 18 The two probes were used separately.…”
Section: ■ Introductionmentioning
confidence: 99%
“…The GTMAC-CS has been reported thereafter to successfully load Parathyroid Hormone-Related Protein 1–34 [ 16 ], BSA [ 17 ], and insulin [ 18 ]. In vitro study showed the protein/GTMAC-CS/TPP nanoparticles demonstrate an initial burst then a slow and continuous release [ 19 ].…”
Section: Introductionmentioning
confidence: 99%
“…Emerging technologies also include the use of nanoparticle complexes for improved drug delivery. As an example, in vivo studies demonstrate an enhanced efficiency and an improved cellular internalization of antioxidants when coupled to chitosan derivatives (26). Finally, antioxidants targeted specifically to the mitochondria have attenuated cell injury in oxidative stress-induced disease models (71,112).…”
Section: Antioxidants As Therapy For Bpdmentioning
confidence: 99%